Isolasi Skopoletin dari Buah Mengkudu (Morinda citrifolia L) dan Uji Aktivitas Antioksidannya

https://doi.org/10.22146/agritech.9598

Sugeng Riyanto(1*), Abdul Rohman(2)

(1) Bagian Kimia Farmasi, Fakultas Farmasi Universitas Gadjah Mada, Sekip Utara, Yogyakarta 55281
(2) Bagian Kimia Farmasi, Fakultas Farmasi Universitas Gadjah Mada, Sekip Utara, Yogyakarta 55281
(*) Corresponding Author

Abstract


Scopoletin has been isolated from chloroform fraction of methanolic extract of Mengkudu fruit (Morinda citrifolia L). Its structure was confirmed using infra red spectroscopy and mass spectroscopy. Scopoletin revealed a scavenging activity of 2,2’-diphenil-1-picrylhydrazil (DPPH) radical by IC 50 348.79 μg/mL, 35 times lower than that of vitamin E (IC 50 9.77 μg/mL). Furthermore, scopoletin also showed an antioxidant activity which was lower than that of vitamin E by using linoleic-thiocyanate method.

ABSTRAK

Skopoletin telah diisolasi dari fraksi kloroform ekstrak metanol buah mengkudu (Morinda citrifolia L) yang strukturnya dikonfirmasikan dengan spektroskopi inframerah dan spektrometri massa. Skopoletin menunjukkan aktivitas penangkapan radikal 2,2’-difenil-1-pikrilhidrazil (DPPH) dengan nilai IC50 348,79 μg/mL, 35 kali lebih lemah dibandingkan dengan vitaminE (IC50 9,77 μg/mL). Skopoletin juga mempunyai aktivitas antioksidan yang lebih lemah dibandingkan dengan vitamin menggunakan metode linoleat-tiosianat.


Keywords


scopoletin; antioxidant; DPPH; and linoleic-thiocyanate

Full Text:

PDF



DOI: https://doi.org/10.22146/agritech.9598

Article Metrics

Abstract views : 1140 | views : 9718

Refbacks

  • There are currently no refbacks.




Copyright (c) 2016 Jurnal Agritech

Creative Commons License
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Agritech has been Indexed by:


Agritech (print ISSN 0216-0455; online ISSN 2527-3825) is published by Faculty of Agricultural Technology, Universitas Gadjah Mada in colaboration with Indonesian Association of Food Technologies.


website statisticsView My Stats