The Profile of Anticancer Activities of Sambiloto Extract (Andrographis paniculata Nees) from Several Locations in East Java

Roihatul Mutiah; Fina  Luthfiana; Arief Suryadinata; Wirda Anggraini; Anik Listiyana

doi:10.22146/jfps.647

Roihatul Mutiah Jurusan Farmasi, Fakultas Kedokteran dan Ilmu Kesehatan, Universitas Islam Negeri Maulana Malik Ibrahim Malang, Malang, Indonesia
Fina Luthfiana Jurusan Farmasi, Fakultas Kedokteran dan Ilmu Kesehatan, Universitas Islam Negeri Maulana Malik Ibrahim Malang, Malang, Indonesia
Arief Suryadinata Jurusan Farmasi, Fakultas Kedokteran dan Ilmu Kesehatan, Universitas Islam Negeri Maulana Malik Ibrahim Malang, Malang, Indonesia
Wirda Anggraini Jurusan Farmasi, Fakultas Kedokteran dan Ilmu Kesehatan, Universitas Islam Negeri Maulana Malik Ibrahim Malang, Malang, Indonesia
Anik Listiyana Jurusan Pendidikan Dokter, Fakultas Kedokteran dan Ilmu Kesehatan, Universitas Islam Negeri Maulana Malik Ibrahim Malang, Malang, Indonesia

Keywords: Andrographis paniculata Nees, East Java, MTT Assay, Activity Profile

Abstract

Sambiloto (Andrographis paniculata Nees) contains andrographolid compound which has potential
as an anticancer. The difference of growth location has affected the distinction of metabolite content. This
study aims to determine the profile of anticancer activities of A. paniculata extract from several locations in
East Java. The extracts from several locations were tested for activity on T47D cancer cell using MTT assay
method. Thus, the result of this study describes that A. paniculata extract from several different locations does
not provide significantly different anticancer activities with the amount of (p>0.05). The extracts which have
moderate anticancer activity were A. paniculata extracts from Selopuro Subdistrict Blitar Regency, Singosari
Subdistrict Malang Regency, Lowokwaru Subdistrict Malang City, Klojen Subdistrict Malang City,
Purwodadi Subdistrict Pasuruan Regency, Purwosari Subdistrict Pasuruan Regency, and Pandaan
Subdistrict Pasuruan Regency