The Efficacy of Mung Bean Drink with Inulin and Iron Tablets in the Erythropoiesis Response of Adolescent Girls with Iron Deficiency Anemia: A Randomized Controlled Trial
Keywords:
mung bean drink, inulin, erythropoiesis, reticulocyte count
Abstract
This study aims to determine the effectiveness of mung bean drink with inulin and iron tablets on the erythropoiesis response as characterized by changes in reticulocyte count of adolescent girls with iron deficiency anemia. This is a non-blinding, randomized controlled trial with pre-test-post-test with control groups research design which was conducted in Sleman Regency, Yogyakarta, Indonesia. Sixty-one adolescent girls with iron deficiency anemia were recruited from junior and senior high schools and then randomized into two groups. The treatment group (n=30) received iron tablets and a mung bean drink with inulin, whereas the control group (n=31) received iron tablets and a palm sugar drink. The intervention was carried out for 12 weeks. Data collection involved interviews, monitoring adherence to drinking, and blood tests. Data were analyzed using Chi-Square Tests, paired T-Tests, and Mann-Whitney Tests. The results showed that there was a significant increase in reticulocyte count after two weeks of intervention in the treatment group (p-value 0.0001) and the control group (p-value 0.001). After four and 12 weeks of intervention, reticulocyte counts of both groups decreased along with increasing hemoglobin levels. In conclusion, the mung bean drink with inulin and iron tablets is effective in the erythropoiesis response.
References
Ahmad A., Tahir., 2017. Role of zinc sulphate for maize (Zea mays l.) and mungbean (Vigna radiata l. wilczek) yield improvement: a review. Bulletin of Biological and Allied Science Research. 2: 1-17.
Akram W., Garud N., Joshi R., 2019. Role of Inulin as prebiotics on inflammatory bowel disease. Drug Discoveries & Therapeutics. 13(1): 1-8.
Al-Dallal S., 2016. Iron deficiency anaemia: a short review. Journal of Cancer Research and Immuno-Oncology. 2(1): 1-6.
Al-Sheraji SH., Ismail A., Manap MY., Mustafa S., Yusof RM., Hassan FA., 2013. Prebiotics as functional foods: a review. Journal of Functional Foods. 5(4): 1542-1553.
Aliviameita and Puspitasari. 2019. Hematology course book. Umsida Press . Sidoarjo, Indonesia.
Amalia A., 2016. The effectiveness of mung bean drink to increase hemoglobin levels. AIPKEMA National Working Meeting. pp 13-18.
Anderson GJ., Frazer DM., 2017. Current understanding of iron homeostasis. American Journal of Clinical Nutrition. 106: 1559S-1566S.
Basith A., Agustina R., Dian N., 2017. Factors Associated with the Incidence of Anemia in Young Women. World of Nursing. 5: 1-10.
Breymann C., Auerbach M., 2017. Iron deficiency in gynecology and obstetrics: clinical implications and management. Hematology Am Soc Hematol Educ Program. 152-9.
Bruinvels G., Burden R., Brown N., Richards T., Pedlar C., 2016. The prevalence and impact of heavy menstrual bleeding (menorrhagia) in elite and non-elite athletes. PLOS ONE | DOI:10.1371/journal.pone.0149881. 1-8.
Burz C., Cismaru A., Pop V., Bojan A., 2018. Iron Deficiency Anemia. Intech. 1-21.
Cairo RCA., Silva LR., Bustani NC., Marques CDF., 2014. Revisión iron deficiency anemia in adolescents: a literature review. Nutrition Hospitalaria, 29: 1240-1249.
Carlson JL., Erickson JM., Hess JM., Gould TJ., Slavin J., 2017. Prebiotic dietary fiber and gut health: comparing the in vitrofermentations of beta-glucan, Inulin and xylooligosaccharide. Nutrients. 9(12): 1-17.
Carolin BT., Suprihatin., Indirasari., Novelia S., 2021. Giving only bean juice to increase hemoglobin levels in anemic students. Journal for Quality in Women's Health. 4(1): 109-114.
Dahiya PK., Linnemann AR., Van Boekel MAJS., Khetarpaul N., Grewal RB., Nout MJR., 2015. Mung bean : technological and nutritional potential. Critical Reviews in Food Science and Nutrition. 8398: 670-688.
Davies J., Kadir RA., 2017. Heavy menstrual bleeding: An update on management. Thrombosis Research 151:S70-S77. DOI: 10.1016/S0049-3848(17)30072-5.
Du J., Cullen JJ., Buettner GR., 2012. Ascorbic acid: chemistry, biology and the treatment of cancer. Biochimica et Biophysica Acta - Reviews on Cancer. 1826(2): 443-457.
Fan CH., Cao JH., Zhang FC., 2016. The prebiotic Inulin as a functional food-a review. European Review for Medical and Pharmacological Sciences. 20(15): 3262-3265.
Faridah U., Indraswari V., 2017. Giving maybe beans as an effort to increase hemoglobin levels in adolescents. The 5th Urecol Proceedings. 215-222.
Fraser IS., Mansour D., Breymann C.,.Hoffman C., Mezzacasa A., Petraglia F., 2014. Prevalence of Heavy Menstrual Bleeding and Experiences of Affected Women in a European Patient Survey. International Journal of Gynecology and Obstetrics. 128(3): 196-200.
Freitas KDC., Amancio OMS., De Morais MB.. 2012. High-performance Inulin and oligofructose prebiotics increase the intestinal absorption of iron in rats with iron deficiency anemia during the growth phase. British Journal of Nutrition. 108(6): 1008-1016.
Geisser P., Burckhardt S., 2011. The pharmacokinetics and pharmacodynamics of iron preparations. Pharmaceutics. 3(1): 12-33.
Georgieff MK., 2017. Iron assessment to protect the developing brain. American Journal of Clinical Nutrition. 106: 1588S-1593S.
Hermoso M., Vucic V., Vollhardt C., Arsic A., Viñas BC., Altaba II., Gurinovic M., Koletzko B., 2011. The effect of iron on cognitive development and function in infants, children and adolescents: A systematic review. Annals of Nutrition and Metabolism. 59(2-4): 154-165.
Herrera SMG., Herrera RR., Lopez MG., Rutiaga OM., Aguilar CN., Esquivel JCC., Martinez LAO., 2015. Inulin in food products: prebiotic and functional ingredient. British Food Journal. 117(1): 371-387.
Hou D., Yousaf L., Xue Y., Hu J., Wu J., Hu X., Feng N., Shen Q., 2019. Mung bean (Vigna radiata L.) : bioactive polyphenols, polysaccharides, peptides, and health benefits. Nutrients. 11(1238): 1-28.
Hurrell R., Egli I., 2010. Iron bioavailability and dietary reference values. American Journal of Clinical Nutrition. 9(5): 1461-1467.
Ivana ZL., Gunawan LS., 2019. Differences of reticulocyte count before and after iron-tablets administration. Journal of Biomedicine. 12(2): 228-235.
Keohane EM., 2016. Hemoglobin metabolism. In: Rodak's Hematology. Elsevier. New Jersey, USA. pp 124-136.
Kiswari R., 2014. Iron deficiency anaemia. In : Hematology and transfusion. PT Erlangga, Jakarta, Indonesia.
Kocaoz S., Cirpan R., Degirmencioglu AZ., 2019. The prevalence and impacts heavy menstrual bleeding on anemia, fatigue and quality of life in women of reproductive age. Pak J Med Sci. 35(2): 365-370.
Kumar D., Singh G., Singh M., Sharma D., Rathore MS., 2012. Diet and functional foods in treatment and maintenance therapy of colon disorders. Journal of Applied Pharmaceutical Science. 2(04): 177-187.
Liutkeviÿius A., Speičienė V., Funk LV., Mieželienė A., Alenčikienė G., Abaravičius A., Bagdonaitė L., Jablonskienė V., Kaminskas A., 2016. An Inulin-Enriched Soy Drink and Its Lowering Effect on Oxidized Low Density Lipoproteins in Healthy Volunteers. Pol. J. Food Nutr. sci. 66(1): 37-41.
Lobera IJ., 2014. Iron deficiency and cognitive functions. Neuropsychiatric Disease and Treatment. 10: 2087-2095.
Mariyona K., 2019. The effectiveness of green bean juice (phaseolus radiatus l) on increasing serum hemoglobin levels in adolescent with anemia. Journal of Medika Tower. 2(1): 21-26.
Maulina N., Choirunissa R., Azzahroh P., 2022. The effects of mung bean juice and Fe tablets on hemoglobin levels of adolescents with anemia in MTs Ar Roudloh, Bandung Regency in 2021. Health Scientific Journal. 14(1): 57-71.
Messiah M., Seiquer I., Navarro MP., 2013. Iron nutrition in adolescence. Critical Reviews in Food Science and Nutrition. 53: 1226-1237.
Munro MG., Boccia R., Friedman AJ., Goodnough LT., James AH., Nelson AL., Ocean A., 2019. Treatment for iron deficiency anemia associated with heavy menstrual bleeding. American Regent. 1-8.
Napolitano N., Dolce A., Celenza G., Grandone E., Perilli MG., Siragusa S., Carta G., Orecchioni A., Mariani G., 2014. Iron-dependent erythropoiesis in women with excessive menstrual blood losses and women with normal menses. Ann Hematol. 93: 557-563.
National Institute for Health and Care Excellence (NICE). 2018. Heavy menstrual bleeding: assessment and management. NICE guideline [NG88]. https://www.nice.org.uk/guidance/NG88/chapter/Recommendations. Accessed 24 Desember 2022.
Parikh P., Bos R., 2018. Improving Iron Bioavailability with Prebiotic Galacto-oligosaccharides. Sight And Life. 32(1): 62-66.
Parmanand BA., Kellingraya L., Galla GL., Basit AW., Susan TSF., Narbada A., 2019. A decrease in iron availability to human gut microbiome reduces the growth of potentially pathogenic gut bacteria: an in vitro colonic fermentation study. Journal of Nutritional Biochemistry. 67: 20-27.
Piva E., Brugnara C., Chiandetti L., Plebani M., 2010. Automated reticulocyte counting: state of the art and clinical applications in the evaluation of erythropoiesis. Clinical Chemistry and Laboratory Medicine. 48: 1369-1380.
Piva E., Brugnara C., Spolaore F., Plebani M., 2015. Clinical utility of reticulocyte parameters. Clinical Chemistry and Laboratory Medicine .35: 133-163.
Riskesdas., 2018. Riskesdas National Report. Health Research and Development Agency, Jakarta, Indonesia. pp 523.
Skrypnik K., Suliburska J., 2018. Association between the gut microbiota and mineral metabolism. Journal of the Science of Food and Agriculture. 98(7): 2449-2460.
Slavin J., 2013. Fiber and prebiotics: mechanisms and health benefits. Nutrients. 5(1435): 1417-1435.
Suega K., 2010. Reticulocyte. Journal of Internal Medicine. 11(3): 191-201.
Suter IK., 2013. Functional food and its development prospects. Paper presented at a One Day Seminar with the theme "The Importance of Natural Food for Long-Term Health" organized by the Student Family Association (IKM) Department of Nutrition, Health Polytechnic Denpasar. Food Technology. 1-17.
Syahendra H., 2020. The difference before and after reticulocytes amount 7 days of treatment on anemia deficiency Fe at Arifin Ahmad Pekanbaru Hospital. Thesis. Padang Pioneer College of Health Sciences Padang, Indonesia.
Tang D., Dong Y., Ren H., Li L., He C., 2014. A review of phytochemistry, metabolite changes, and medicinal uses of the common food mung bean and its sprouts (Vigna radiata). Chemistry Central Journal. 8(1): 1-9.
Telaumbenua AC., Lillah Almurdi., 2013. Comparing the number of reticulosits in iron deficiency anemia patients before and after treatment with the preparate Fe. Meditory Scientific Health Journal. 2(2): 12-17.
Urrechaga E., Borque L., Escanero JF., 2012. Erythrocyte and reticulocyte indices in the assessment of erythropoiesis activity and iron availability. International Journal of Laboratory Hematolog. 35: 144-149.
Usman H., Sifia NN., Dewie A., Mariani E., 2021. Giving mung bean juice and iron tablets increase hemoglobin levels in adolescent. Smart Midwife Journal. 3(4): 183-190.
Valcheva R., Koleva P., Martínez I., Walter J., Gänzle MG., Dieleman LA., 2019. Inulin-type fructans improve active ulcerative colitis associated with microbiota changes and increased short-chain fatty acids levels. Gut Microbes. 10(3): 334-357.
Weinborn V., Valenzuela C., Olivares M., Arredondo M., Weill R., Pizarro F., 2017. Prebiotics increase heme iron bioavailability and do not affect non-heme iron bioavailability in humans. Food & Function. 8: 1994-1999.
Wilson B., Whelan K., 2017. Prebiotic Inulin-type fructans and galacto-oligosaccharides: definition, specificity, function, and application in gastrointestinal disorders. Journal of Gastroenterology and Hepatology. 32(1): 64-68.
World Health Organization., 2011. Haemoglobin concentrations for the diagnosis of anaemia and assessment of severity. World Health Organization Publisher and distributor, Geneva, Switzerland. pp 1-6.
Zaimy S., Darma IY., Idaman M., 2010. The effectivenes of green bean juice on haemoglobin levels in adolescents at dormitory institute of health science Syedza Saintika Padang. Meditory Scientific Health Journal. 4(1): 56-60.
Zimmermann M., Chassard C., Rohner F., N'Goran EK., Nindjin C., Dostal A., Utzinger J., Ghattas H., Lacroix C., Hurrell RF., 2010. The effects of iron fortification on the gut microbiota in African children: A randomized controlled trial in Côte d'Ivoire. American Journal of Clinical Nutrition, 92(6): 1406-1415
Akram W., Garud N., Joshi R., 2019. Role of Inulin as prebiotics on inflammatory bowel disease. Drug Discoveries & Therapeutics. 13(1): 1-8.
Al-Dallal S., 2016. Iron deficiency anaemia: a short review. Journal of Cancer Research and Immuno-Oncology. 2(1): 1-6.
Al-Sheraji SH., Ismail A., Manap MY., Mustafa S., Yusof RM., Hassan FA., 2013. Prebiotics as functional foods: a review. Journal of Functional Foods. 5(4): 1542-1553.
Aliviameita and Puspitasari. 2019. Hematology course book. Umsida Press . Sidoarjo, Indonesia.
Amalia A., 2016. The effectiveness of mung bean drink to increase hemoglobin levels. AIPKEMA National Working Meeting. pp 13-18.
Anderson GJ., Frazer DM., 2017. Current understanding of iron homeostasis. American Journal of Clinical Nutrition. 106: 1559S-1566S.
Basith A., Agustina R., Dian N., 2017. Factors Associated with the Incidence of Anemia in Young Women. World of Nursing. 5: 1-10.
Breymann C., Auerbach M., 2017. Iron deficiency in gynecology and obstetrics: clinical implications and management. Hematology Am Soc Hematol Educ Program. 152-9.
Bruinvels G., Burden R., Brown N., Richards T., Pedlar C., 2016. The prevalence and impact of heavy menstrual bleeding (menorrhagia) in elite and non-elite athletes. PLOS ONE | DOI:10.1371/journal.pone.0149881. 1-8.
Burz C., Cismaru A., Pop V., Bojan A., 2018. Iron Deficiency Anemia. Intech. 1-21.
Cairo RCA., Silva LR., Bustani NC., Marques CDF., 2014. Revisión iron deficiency anemia in adolescents: a literature review. Nutrition Hospitalaria, 29: 1240-1249.
Carlson JL., Erickson JM., Hess JM., Gould TJ., Slavin J., 2017. Prebiotic dietary fiber and gut health: comparing the in vitrofermentations of beta-glucan, Inulin and xylooligosaccharide. Nutrients. 9(12): 1-17.
Carolin BT., Suprihatin., Indirasari., Novelia S., 2021. Giving only bean juice to increase hemoglobin levels in anemic students. Journal for Quality in Women's Health. 4(1): 109-114.
Dahiya PK., Linnemann AR., Van Boekel MAJS., Khetarpaul N., Grewal RB., Nout MJR., 2015. Mung bean : technological and nutritional potential. Critical Reviews in Food Science and Nutrition. 8398: 670-688.
Davies J., Kadir RA., 2017. Heavy menstrual bleeding: An update on management. Thrombosis Research 151:S70-S77. DOI: 10.1016/S0049-3848(17)30072-5.
Du J., Cullen JJ., Buettner GR., 2012. Ascorbic acid: chemistry, biology and the treatment of cancer. Biochimica et Biophysica Acta - Reviews on Cancer. 1826(2): 443-457.
Fan CH., Cao JH., Zhang FC., 2016. The prebiotic Inulin as a functional food-a review. European Review for Medical and Pharmacological Sciences. 20(15): 3262-3265.
Faridah U., Indraswari V., 2017. Giving maybe beans as an effort to increase hemoglobin levels in adolescents. The 5th Urecol Proceedings. 215-222.
Fraser IS., Mansour D., Breymann C.,.Hoffman C., Mezzacasa A., Petraglia F., 2014. Prevalence of Heavy Menstrual Bleeding and Experiences of Affected Women in a European Patient Survey. International Journal of Gynecology and Obstetrics. 128(3): 196-200.
Freitas KDC., Amancio OMS., De Morais MB.. 2012. High-performance Inulin and oligofructose prebiotics increase the intestinal absorption of iron in rats with iron deficiency anemia during the growth phase. British Journal of Nutrition. 108(6): 1008-1016.
Geisser P., Burckhardt S., 2011. The pharmacokinetics and pharmacodynamics of iron preparations. Pharmaceutics. 3(1): 12-33.
Georgieff MK., 2017. Iron assessment to protect the developing brain. American Journal of Clinical Nutrition. 106: 1588S-1593S.
Hermoso M., Vucic V., Vollhardt C., Arsic A., Viñas BC., Altaba II., Gurinovic M., Koletzko B., 2011. The effect of iron on cognitive development and function in infants, children and adolescents: A systematic review. Annals of Nutrition and Metabolism. 59(2-4): 154-165.
Herrera SMG., Herrera RR., Lopez MG., Rutiaga OM., Aguilar CN., Esquivel JCC., Martinez LAO., 2015. Inulin in food products: prebiotic and functional ingredient. British Food Journal. 117(1): 371-387.
Hou D., Yousaf L., Xue Y., Hu J., Wu J., Hu X., Feng N., Shen Q., 2019. Mung bean (Vigna radiata L.) : bioactive polyphenols, polysaccharides, peptides, and health benefits. Nutrients. 11(1238): 1-28.
Hurrell R., Egli I., 2010. Iron bioavailability and dietary reference values. American Journal of Clinical Nutrition. 9(5): 1461-1467.
Ivana ZL., Gunawan LS., 2019. Differences of reticulocyte count before and after iron-tablets administration. Journal of Biomedicine. 12(2): 228-235.
Keohane EM., 2016. Hemoglobin metabolism. In: Rodak's Hematology. Elsevier. New Jersey, USA. pp 124-136.
Kiswari R., 2014. Iron deficiency anaemia. In : Hematology and transfusion. PT Erlangga, Jakarta, Indonesia.
Kocaoz S., Cirpan R., Degirmencioglu AZ., 2019. The prevalence and impacts heavy menstrual bleeding on anemia, fatigue and quality of life in women of reproductive age. Pak J Med Sci. 35(2): 365-370.
Kumar D., Singh G., Singh M., Sharma D., Rathore MS., 2012. Diet and functional foods in treatment and maintenance therapy of colon disorders. Journal of Applied Pharmaceutical Science. 2(04): 177-187.
Liutkeviÿius A., Speičienė V., Funk LV., Mieželienė A., Alenčikienė G., Abaravičius A., Bagdonaitė L., Jablonskienė V., Kaminskas A., 2016. An Inulin-Enriched Soy Drink and Its Lowering Effect on Oxidized Low Density Lipoproteins in Healthy Volunteers. Pol. J. Food Nutr. sci. 66(1): 37-41.
Lobera IJ., 2014. Iron deficiency and cognitive functions. Neuropsychiatric Disease and Treatment. 10: 2087-2095.
Mariyona K., 2019. The effectiveness of green bean juice (phaseolus radiatus l) on increasing serum hemoglobin levels in adolescent with anemia. Journal of Medika Tower. 2(1): 21-26.
Maulina N., Choirunissa R., Azzahroh P., 2022. The effects of mung bean juice and Fe tablets on hemoglobin levels of adolescents with anemia in MTs Ar Roudloh, Bandung Regency in 2021. Health Scientific Journal. 14(1): 57-71.
Messiah M., Seiquer I., Navarro MP., 2013. Iron nutrition in adolescence. Critical Reviews in Food Science and Nutrition. 53: 1226-1237.
Munro MG., Boccia R., Friedman AJ., Goodnough LT., James AH., Nelson AL., Ocean A., 2019. Treatment for iron deficiency anemia associated with heavy menstrual bleeding. American Regent. 1-8.
Napolitano N., Dolce A., Celenza G., Grandone E., Perilli MG., Siragusa S., Carta G., Orecchioni A., Mariani G., 2014. Iron-dependent erythropoiesis in women with excessive menstrual blood losses and women with normal menses. Ann Hematol. 93: 557-563.
National Institute for Health and Care Excellence (NICE). 2018. Heavy menstrual bleeding: assessment and management. NICE guideline [NG88]. https://www.nice.org.uk/guidance/NG88/chapter/Recommendations. Accessed 24 Desember 2022.
Parikh P., Bos R., 2018. Improving Iron Bioavailability with Prebiotic Galacto-oligosaccharides. Sight And Life. 32(1): 62-66.
Parmanand BA., Kellingraya L., Galla GL., Basit AW., Susan TSF., Narbada A., 2019. A decrease in iron availability to human gut microbiome reduces the growth of potentially pathogenic gut bacteria: an in vitro colonic fermentation study. Journal of Nutritional Biochemistry. 67: 20-27.
Piva E., Brugnara C., Chiandetti L., Plebani M., 2010. Automated reticulocyte counting: state of the art and clinical applications in the evaluation of erythropoiesis. Clinical Chemistry and Laboratory Medicine. 48: 1369-1380.
Piva E., Brugnara C., Spolaore F., Plebani M., 2015. Clinical utility of reticulocyte parameters. Clinical Chemistry and Laboratory Medicine .35: 133-163.
Riskesdas., 2018. Riskesdas National Report. Health Research and Development Agency, Jakarta, Indonesia. pp 523.
Skrypnik K., Suliburska J., 2018. Association between the gut microbiota and mineral metabolism. Journal of the Science of Food and Agriculture. 98(7): 2449-2460.
Slavin J., 2013. Fiber and prebiotics: mechanisms and health benefits. Nutrients. 5(1435): 1417-1435.
Suega K., 2010. Reticulocyte. Journal of Internal Medicine. 11(3): 191-201.
Suter IK., 2013. Functional food and its development prospects. Paper presented at a One Day Seminar with the theme "The Importance of Natural Food for Long-Term Health" organized by the Student Family Association (IKM) Department of Nutrition, Health Polytechnic Denpasar. Food Technology. 1-17.
Syahendra H., 2020. The difference before and after reticulocytes amount 7 days of treatment on anemia deficiency Fe at Arifin Ahmad Pekanbaru Hospital. Thesis. Padang Pioneer College of Health Sciences Padang, Indonesia.
Tang D., Dong Y., Ren H., Li L., He C., 2014. A review of phytochemistry, metabolite changes, and medicinal uses of the common food mung bean and its sprouts (Vigna radiata). Chemistry Central Journal. 8(1): 1-9.
Telaumbenua AC., Lillah Almurdi., 2013. Comparing the number of reticulosits in iron deficiency anemia patients before and after treatment with the preparate Fe. Meditory Scientific Health Journal. 2(2): 12-17.
Urrechaga E., Borque L., Escanero JF., 2012. Erythrocyte and reticulocyte indices in the assessment of erythropoiesis activity and iron availability. International Journal of Laboratory Hematolog. 35: 144-149.
Usman H., Sifia NN., Dewie A., Mariani E., 2021. Giving mung bean juice and iron tablets increase hemoglobin levels in adolescent. Smart Midwife Journal. 3(4): 183-190.
Valcheva R., Koleva P., Martínez I., Walter J., Gänzle MG., Dieleman LA., 2019. Inulin-type fructans improve active ulcerative colitis associated with microbiota changes and increased short-chain fatty acids levels. Gut Microbes. 10(3): 334-357.
Weinborn V., Valenzuela C., Olivares M., Arredondo M., Weill R., Pizarro F., 2017. Prebiotics increase heme iron bioavailability and do not affect non-heme iron bioavailability in humans. Food & Function. 8: 1994-1999.
Wilson B., Whelan K., 2017. Prebiotic Inulin-type fructans and galacto-oligosaccharides: definition, specificity, function, and application in gastrointestinal disorders. Journal of Gastroenterology and Hepatology. 32(1): 64-68.
World Health Organization., 2011. Haemoglobin concentrations for the diagnosis of anaemia and assessment of severity. World Health Organization Publisher and distributor, Geneva, Switzerland. pp 1-6.
Zaimy S., Darma IY., Idaman M., 2010. The effectivenes of green bean juice on haemoglobin levels in adolescents at dormitory institute of health science Syedza Saintika Padang. Meditory Scientific Health Journal. 4(1): 56-60.
Zimmermann M., Chassard C., Rohner F., N'Goran EK., Nindjin C., Dostal A., Utzinger J., Ghattas H., Lacroix C., Hurrell RF., 2010. The effects of iron fortification on the gut microbiota in African children: A randomized controlled trial in Côte d'Ivoire. American Journal of Clinical Nutrition, 92(6): 1406-1415
Published
2024-03-25
How to Cite
Putri, F., Hadiati, D. R., Ratnaningsih, T., & Lestari, L. A. (2024). The Efficacy of Mung Bean Drink with Inulin and Iron Tablets in the Erythropoiesis Response of Adolescent Girls with Iron Deficiency Anemia: A Randomized Controlled Trial. Indonesian Journal of Pharmacy, 35(1), 138-146. https://doi.org/10.22146/ijp.6854
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Research Article
