Optimization of Polysorbate 80 and Sorbitan Monooleate 80 aas Emulsifiers in Foundation Makeup Containing Ethyl Cinnamate
Abstract
Cosmetic foundation is a type of decorative makeup and commonly include a sunscreen agent. Ethyl cinnamate is one of the potential organic essential oil sunscreens. Nevertheless, there is little study on ethyl cinnamate usage in cosmetics, particularly oil-in-water foundation cream. Using an emulsifier in oil-in-water foundation cream a higher concentration does not guarantee higher oil phase recovery. However, using two combinations of emulsifier such as polysorbate 80 and sorbitan monooleate 80 with the optimum combination can be the right solution. This study aims to optimize polysorbate 80 and sorbitan monooleate 80 in a cream foundation using ethyl cinnamate as an active ingredient designed to have an effective ability to protect facial skin from ultraviolet radiation and are safe to use. The optimization formulas design of the emulsifier combination in foundation cream was made using the Simplex Lattice Design method with help Design Expert version 10.0.1. Parameter optimization were the value of pH, viscosity, spreadability, adhesion, and Sun Protection Factor (SPF) value. The stability test and skin irritation test of optimum formula were also conducted. As a positive control, Revlon Colorstay Foundation as a brand cosmetic foundation was used (National Food and Drug Agency of Indonesia number : NA18140300519). The optimum ratio of polysorbate 80 and sorbitan monooleat 80 were 9.565 and 1.435 with the physical characteristics of pH 6.478+0.008; viscosity 5844.2+31.82 cPs; spreadability 6.16+0.11 cm; adhesion 3.346+0.14 seconds; SPF Value 22.385+0.48, and no irritation symptoms. The ethyl cinnamate foundation created was physically stable, had a pleasing look, and did not irritate the skin, making it safe to wear. It also provides efficient UV radiation protection.
References
[2] & S. B. M. Das, S. Mondal, “n Vitro Sun Protection Factor Determination From Dried Leaves Of Elephantopus Scaber L. Using Ethanolic Extract,” Indian J.L.Sci, vol. 6, no. 1, pp. 43–46, 2017.
[3] I. A. Damayani, V. Paramita, and M. E. Yulianto, “The Effect of HLB Surfactant Value on The Characteristics of Emulsion Biodiesel Palm Oil Using Homogenizer,” vol. 3, no. April, pp. 9–13, 2021.
[4] Yuliana Purwaningsih, Mighfar Syukur, Ungsari Rizki Eka Purwanto, Etil Sinamat : Sintesis dan Aktivitasnya sebagai Agen Tabir Surya. 2021.
[5] M. . Mansur, J.., Breder, M.., dan Azulay, “Determination of sun protection factor (SPF) of sunscreens by ultraviolet spectrophotometry.,” Rev. Bras. Ciencias Farm. J. Pharm. Sci., vol. 6, pp. 121–124, 1986.
[6] M. C. M. Pratasik, P. V. Y. Yamlean, and W. I. Wiyono, “FORMULASI DAN UJI STABILITAS FISIK SEDIAAN KRIM EKSTRAK ETANOL DAUN SESEWANUA (Clerodendron squamatum Vahl.),” Pharmacon, vol. 8, no. 2, p. 261, 2019, doi: 10.35799/pha.8.2019.29289.
[7] A. Noviandini, “Patch Test dan Repeated Open Application Test (ROAT) pada Dermatitis Kontak Alergika,” Berk. Ilmu Kesehat. Kulit dan Kelamin, vol. 26, no. 3, pp. 220–228, 2014.
[8] Stat-Ease, “Stat-Ease » v11 » General Sequence of Analysis » ANOVA Output.” https://www.statease.com/docs/v11/contents/analysis/anova-output/ (accessed Nov. 03, 2021).
[9] D. H. Chou J, Robinson T, “Rapid comparison of UVB absorption effectiveness of various sunscreens by UV-Vis spectroscopy,” J Anal Bioanal Tech, vol. 8, no. 2, p. 355, 2017.
[10] M. Z. Imam S, Azhar I, “In-vitro evaluation of sun protection factor of a cream formulation prepared from extracts of Musa accuminata (L.), Psidium guava (L.) and Pyrus communis (L.).,” Asian J Pharm Clin Res, vol. 8, pp. 234–237, 2015.
