Thermo- and pH-Responsive Behavior of Poly( N -isopropylacrylamide)-Block-Poly[(2-dimethylamino)ethyl Methacrylate]

Noverra Mardhatillah Nizardo; Rida Hasna Fadhilah; Ivandini Tribidasari Anggraningrum

doi:10.22146/ijc.79264

Thermo- and pH-Responsive Behavior of Poly(N-isopropylacrylamide)-Block-Poly[(2-dimethylamino)ethyl Methacrylate]

https://doi.org/10.22146/ijc.79264

Noverra Mardhatillah Nizardo^(1*), Rida Hasna Fadhilah⁽²⁾, Ivandini Tribidasari Anggraningrum⁽³⁾

(1) Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Indonesia, Kampus UI, Depok 16424, Indonesia
(2) Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Indonesia, Kampus UI, Depok 16424, Indonesia
(3) Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Indonesia, Kampus UI, Depok 16424, Indonesia
(*) Corresponding Author

Abstract

The influence of poly(2-dimethylamino)ethyl methacrylate (PDMAEMA) block on the thermo- and pH-responsive behavior of poly(N-isopropyl acrylamide)-block-poly[(2-dimethylamino)ethyl methacrylate)] (PNIPAM-b-PDMAEMA) was studied. The block copolymers were synthesized using reversible addition-fragmentation chain transfer (RAFT) polymerization by varying the chain length of the second block (PDMAEMA). ¹H-NMR and FTIR spectra confirmed the formation of block copolymers PNIPAM₂₁-b-PDMAEMA₂ and PNIPAM₂₁-b-PDMAEMA₇ with the corresponding molar masses from the GPC data. Thermo- and pH-responsive behavior of block copolymers was investigated in phosphate buffer with various pHs. Interesting results showed that the hydrophilic carboxyl end group and the hydrophobic dodecyl end group of the RAFT agent affected the resulting phase transition temperature (T_c), while the T_c was found to be low in the acidic environment. Moreover, larger particle sizes of PNIPAM₂₁‑b‑PDMAEMA₂ were found with a pH of 9. It is noteworthy, that the resulted block copolymers might have the potential use in a drug delivery system.

Keywords

block copolymer; PNIPAM; PDMAEMA; thermo-responsive polymers; pH-responsive polymers

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DOI: https://doi.org/10.22146/ijc.79264