Sesquiterpenoids from the Stem Bark of  Lansium domesticum  Corr. Cv. Kokossan and Their Cytotoxic Activity against MCF-7 Breast Cancer Cell Lines

Siska Elisahbet Sinaga; Tri Mayanti; Al Arofatus Naini; Desi Harneti; Nurlelasari Nurlelasari; Rani Maharani; Kindi Farabi; Unang Supratman; Sofa Fajriah; Mohamad Nurul Azmi

doi:10.22146/ijc.72742

Sesquiterpenoids from the Stem Bark of Lansium domesticum Corr. Cv. Kokossan and Their Cytotoxic Activity against MCF-7 Breast Cancer Cell Lines

https://doi.org/10.22146/ijc.72742

Siska Elisahbet Sinaga⁽¹⁾, Tri Mayanti⁽²⁾, Al Arofatus Naini⁽³⁾, Desi Harneti⁽⁴⁾, Nurlelasari Nurlelasari⁽⁵⁾, Rani Maharani⁽⁶⁾, Kindi Farabi⁽⁷⁾, Unang Supratman^(8*), Sofa Fajriah⁽⁹⁾, Mohamad Nurul Azmi⁽¹⁰⁾

(1) Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jl. Raya Bandung-Sumedang Km. 21, Jatinangor, Sumedang 45363, Indonesia
(2) Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jl. Raya Bandung-Sumedang Km. 21, Jatinangor, Sumedang 45363, Indonesia
(3) Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jl. Raya Bandung-Sumedang Km. 21, Jatinangor, Sumedang 45363, Indonesia
(4) Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jl. Raya Bandung-Sumedang Km. 21, Jatinangor, Sumedang 45363, Indonesia
(5) Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jl. Raya Bandung-Sumedang Km. 21, Jatinangor, Sumedang 45363, Indonesia
(6) Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jl. Raya Bandung-Sumedang Km. 21, Jatinangor, Sumedang 45363, Indonesia; Central Laboratory of Universitas Padjadjaran, Jl. Raya Bandung-Sumedang Km. 21, Jatinangor, Sumedang 45363, Indonesia
(7) Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jl. Raya Bandung-Sumedang Km. 21, Jatinangor, Sumedang 45363, Indonesia
(8) Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jl. Raya Bandung-Sumedang Km. 21, Jatinangor, Sumedang 45363, Indonesia; Central Laboratory of Universitas Padjadjaran, Jl. Raya Bandung-Sumedang Km. 21, Jatinangor, Sumedang 45363, Indonesia
(9) Research Center for Raw Materials for Medicine and Traditional Medicine, National Research and Innovation Agency (BRIN), Tangerang Selatan, Banten 15314, Indonesia
(10) School of Chemical Sciences, Universiti Sains Malaysia, 11800 Minden, Penang, Malaysia
(*) Corresponding Author

Abstract

The n-hexane fraction from the stem bark of Lansium domesticum Corr. Cv. Kokosan afforded 3 sesquiterpenoids, namely eudesm-4(15),7-dien-1β-ol (1), eudesm-4(15)-ene-1β,6α-diol (2), and octahydro-4-hydroxy-3a-methyl-7-methylene-a-(1-methylethyl)-1H-indene-1-methanol (3). These three compounds were discovered in the Lansium genus for the first time. Their chemical structures were determined based on data generated from various spectroscopic methods, including one- and two-dimensional NMR, as well as mass spectroscopy. Sesquiterpenoid compounds (1-3) have also been evaluated on MCF-7 breast cancer cell lines and the compound 1 showed the strongest activity with an IC₅₀ value of 17.97 µg/mL while compounds 2 and 3 showed moderate and weak activity with IC₅₀ values of 121.65 and 201.57 µg/mL, respectively. The implication of the findings of these compounds is as an illustration that one of these sesquiterpenoids has potential as an anticancer with the presence of double bond which played important role in the cytotoxic activity that can be studied for new drug discovery.

Keywords

cytotoxic activity; Lansium domesticum Corr. Cv. Kokosan; MCF-7 cell lines; sesquiterpenoid

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DOI: https://doi.org/10.22146/ijc.72742