Synthesis, Characterization and Biological Efficacies from Some New Dinuclear Metal Complexes for Base 3-(3,4-Dihydroxy-phenyl)-2-[(2-hydroxy-3-methylperoxy-benzylidene)-amino]-2-methyl Propionic Acid

Shatha Mohammed Hassan Obaid; Jasim Shihab Sultan; Abbas Ali Salih Al-Hamdani

doi:10.22146/ijc.49842

Synthesis, Characterization and Biological Efficacies from Some New Dinuclear Metal Complexes for Base 3-(3,4-Dihydroxy-phenyl)-2-[(2-hydroxy-3-methylperoxy-benzylidene)-amino]-2-methyl Propionic Acid

https://doi.org/10.22146/ijc.49842

Shatha Mohammed Hassan Obaid⁽¹⁾, Jasim Shihab Sultan⁽²⁾, Abbas Ali Salih Al-Hamdani^(3*)

(1) Department of Chemistry, College of Education for Pure Science – Ibn Al-Haitham, University of Baghdad, Iraq
(2) Department of Chemistry, College of Education for Pure Science – Ibn Al-Haitham, University of Baghdad, Iraq
(3) Department of Chemistry, College of Science for Women, University of Baghdad, Baghdad, Iraq
(*) Corresponding Author

Abstract

The reaction of methyldopa with o-vanillin in refluxing ethanol afforded Schiff base and characterized through physical analysis with a number of spectra also the study of biological activity. The geometry of the Schiff base was identified through using (C.H.N) analysis, Mass, ¹H-NMR, FT-IR, UV-Vis spectroscopy. Metal complexes of Cr³⁺, Mn²⁺, Co²⁺, Ni²⁺, Cu²⁺, Zn²⁺, Cd²⁺ and Hg²⁺ with Schiff base have been prepared in the molar ratio 2:1 (Metal:L), (L = Schiff base ligand) except Hg²⁺ at molar ratio 1:1 (Hg:L). The prepared complexes were characterized by using Mass, FT-IR and UV-Vis spectral studies, on other than magnetic properties and flame atomic absorption, conductivity measurements. According to the results a dinuclear octahedral geometry has been suggested for Cr³⁺, Mn²⁺, Co²⁺, Ni²⁺, Cu²⁺ and Zn²⁺ complexes, dinuclear tetrahedral for Cd²⁺ and mononuclear tetrahedral for Hg²⁺ complex. This work highlights the relevance of metal complexation strategy to stabilize the ligands and improve their bioactivity. Schiff base complexes have been screen for their antibacterial activity against Gram negative and positive bacteria and antifungal activity showing promising antibacterial and biological activity.

Keywords

methyldopa; o-vanillin; Schiff base complexes; spectral studies; biological efficacy

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DOI: https://doi.org/10.22146/ijc.49842