Synthesis, Radiochemical Purity Control and Stability of Scandium-46-1,4,7-triazacyclononane-1,4,7-triacetic acid (46Sc-NOTA)

https://doi.org/10.22146/ijc.24467

Duyeh Setiawan(1*), Iwan Hastiawan(2), Asri Nurul Bashiroh(3)

(1) Center for Applied Science and Nuclear Technology-National Nuclear Energy Agency
(2) Department Chemistry, Faculty Mathematics and Natural Sciences, Universitas Padjadjaran
(3) Department Chemistry, Faculty Mathematics and Natural Sciences, Universitas Padjadjaran
(*) Corresponding Author

Abstract


Radiotherapy is one of healing method of cancer using radionuclide elements. The radionuclide scandium-46 (46Sc) has a half-life of 83.8 days, beta emission 0.35 MeV and gamma emission 899 and 1120 keV is suitable for studying the chemical aspects, synthesis and stability of scandium complex for radiotherapy. The purposes of this research are synthesis of scandium-46-1,4,7-triazacyclononane-1,4,7-triacetic acid (46Sc-NOTA) labeled compound based on formation of a complex bonding in stoichiometry between radioisotope 46Sc and 1,4,7-triazacyclononane-1,4,7-triacetic acid (NOTA) ligand, and radiochemical purity and stability assay of 46Sc-NOTA. In this research, conducted that optimum moles several variables, namely moles comparison and pH effect was used. The result are optimum conclusion of mole comparison between radioisotope and ligand was 1:2 (46Sc : NOTA) and environment at pH 5. The radiochemical purity and stability assay of 46Sc-NOTA was carried out by paper chromatography and the result showed that 46Sc-NOTA has radiochemical purity of 99.09 ± 0.2% and remained stable for 9 days.

Keywords


radioisotope 46Sc; NOTA; synthesis; stability; radiotherapy

Full Text:

Full Text PDF


References

[1] Martins, P.A., da Silva, J.L., Ramos, M.P.S., de Oliveira, I.M., Felgueiras, C.F., Herrerias, R., Júnior, C.L.Z., Mengatti, J., Fukumori, N.T.O., and Matsuda, M.M.N., 2011, Radiochemical stability of radiopharmaceutical preparations, International Nuclear Atlantic Conference - INAC 2011, Belo Horizonte, MG, Brazil, October 24-28, 2011.

[2] Majkowska-Pilip A., and Bilewicz, A., 2011, Macrocyclic complexes of scandium radionuclides as precursors for diagnostic and therapeutic radiopharmaceuticals, J. Inorg. Biochem., 105 (2), 313–320.

[3] Notni, J., Hermann, P., Havlícková, J., Kotek, J., Kubícek, V., Plutnar, J., Loktionova, N., Riss, P.J., Rösch, F., and Lukes, I., 2010, A triazacyclononane-based bifunctional phosphinate ligand for the preparation of multimeric 68Ga tracers for positron emission tomography, Chem. Eur. J., 16 (24), 7174–7185.

[4] Varasteh, Z., Velikyan, I., Lindeberg, G., Sörensen, J., Larhed, M., Sandström, M., Selvaraju, R.K., Malmberg, J., Tolmachev, V., and Orlova, A., 2013, Synthesis and characterization of a high affinity NOTA-conjugated bombesin antagonist for GRPR-targeted tumor imaging, Bioconjugate Chem., 24 (7), 1144–1153.

[5] Anissa, I.T., Setiawan, D., and Hastiawan, I., 2014, Synthesis of complex compounds (scandium-47)-1,4,7-triazacyclononane-1,4,7-triacetate acid (NOTA) as precursor to radiotherapy and diagnostic imaging, Essay, Undergraduate Studies Program Faculty of Chemistry, Padjadjaran University, Bandung - Indonesia.

[6] Pniok, M., Kubíček, V., Havlíčková, J., Kotek, J., Sabatie-Gogová, A., Plutnar, J., Huclier-Markai, S., and Hermann, P., 2014, Thermodynamic and kinetic study of scandium(III) complexes of DTPA and DOTA: a step toward scandium radiopharmaceuticals, Chem. Eur. J., 20 (26), 7944–7955.

[7] Setiawan, D., and Hastiawan, I., 2014, Sintesis dan karakterisasi 1,4,7-triazasiklononana-1,4,7-asam triasetat (NOTA) sebagai ligan dalam senyawa kompleks sediaan radioterapi, JCNA, 2 (1), 66–71.

[8] Holub, G.J., Meckel, M., Kubícek, V., Rösch, F., and Hermann, P., 2015, Gallium(III) complexes of NOTA-bis (phosphonate) conjugates as PET radiotracers for bone imaging, Contrast Media Mol. Imaging, 10 (2),122–134.

[9] Setiawan, D., and Anggraeni, R., 2015, Preparation and characterization of radioisotopes 46ScCl3 results irradiation natural scandium oxide materials target, Proceedings of the National Seminar on Nuclear Science and Technology, PSTNT-BATAN, 207–213.

[10] Idzni, F., Setiawan, D., and Hastiawan, I., 2015, Synthesis and characterization of ligand 1,4,7-triazacyclononane-N, N', N''- triacetate acid (NOTA) with chloroacetic acid precursors, Essay, Undergraduate Studies Program Faculty of Chemistry, Padjadjaran University, Bandung - Indonesia.

[11] Setiawan, D., and Mulyati, T.S., 2015, Pembuatan dan analisis fisiko-kimia radioisotop skandium-47 (47sc) dari bahan sasaran titanium oksida alam, JSTNI, 16 (1), 63–70.

[12] Setiadi, Y., Setiawan, D., Daruwati, I., Hastiawan, I., and Bashiroh, A.N., 2015, Synthesis and characterization of a Scandium-46 complexes with polyammino carboxylate based bifunctional agent as precursor in bleomycin labeling, Proceedings of the National Seminar on Nuclear Energy and Technology, Denpasar, 591–598.

[13] Moghaddam-Banaem, L., Jalilian, A.R., Pourjavid, M., Bahrami-Samani, A., Mazidi, M., Ghannadi-and Maragheh, M., 2012, Preparation and quality control of scandium-46 bleomycin as a possible therapeutic agent, Iran. J. Nucl. Med., 20 (1), 19–24.

[14] Mamtimin, M., Harmon, F., and Starovoitova, V.N., 2015, Sc-47 production from titanium targets using electron linacs, Appl. Radiat. Isot., 102, 1–42.

[15] Maskur, Setiyowati, S., Ramli, M, Cecep, R.T., Subur, M., and Misyetti, 2011, Preparation, characterization, and stability test radiopharmaceuticals 177Lu-CTMP for palliative pain bone metastasis, Proceedings of Scientific Meeting Radioisotopes, Radiopharmaceuticals and Cyclotron, Radioisotopes and Radiopharmaceuticals Center-Batan Serpong.



DOI: https://doi.org/10.22146/ijc.24467

Article Metrics

Abstract views : 4094 | views : 2868


Copyright (c) 2017 Indonesian Journal of Chemistry

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

 

Indonesian Journal of Chemistry (ISSN 1411-9420 /e-ISSN 2460-1578) - Chemistry Department, Universitas Gadjah Mada, Indonesia.

Web Analytics View The Statistics of Indones. J. Chem.