PHENOLIC COMPOUND FROM THE STEM BARK OF MANGGIS HUTAN (Garcinia bancana Miq.) AND THEIR ANTIOXIDANT ACTIVITY

https://doi.org/10.22146/ijc.21550

Muharni Muharni(1*), Supriyatna Supriyatna(2), Husein H. Bahti(3), Dachriyanus Dachriyanus(4)

(1) Department of Chemistry, Faculty of Mathematics and Natural Sciences, Sriwijaya University, Ogan Ilir, Sumatera Selatan
(2) Faculty of Pharmacy, Padjadjaran University, Jatinangor, Sumedang, Indonesia
(3) Department of Chemistry, Faculty of Mathematics and Natural Sciences, Padjadjaran University, Jatinangor, Sumedang
(4) Department of Pharmacy, Faculty of Mathematics and Natural Sciences, Andalas University, Limau Manis, Padang
(*) Corresponding Author

Abstract


A phenolic compoud, (-)-epicatechin, was isolated from  the stem bark of Garcinia bancana. The structure of this compound was determined base on spectroscopic  data such as including UV, IR, 1-D, 2-D NMR, and comparison with the reported data. Biological activity of this compound at free radical scavenging activity by 1,1-diphenyl-2-picrylhydrazyl radical (DPPH) and inhibitory xanthine oxidase(XO) activity showed that (-)- epicathechin active at two methods with IC50 value 8.1 and 8.6 mg/mL respectively.


Keywords


phenolic; (-)-epicatechin; Garcinia bancana; DPPH; XO

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DOI: https://doi.org/10.22146/ijc.21550

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Indonesian Journal of Chemistry (ISSN 1411-9420 /e-ISSN 2460-1578) - Chemistry Department, Universitas Gadjah Mada, Indonesia.

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