6,6’-DIMETHOXY-4,4’-DIHYDROXY-3’,2’-FURANO-ISOFLAVANE, A NEW COMPOUND FROM  Melochia umbellata  (Houtt.) Stapf  var.  Degrabrata K. ( Paliasa )

Erwin Erwin; Alfian Noor; Nunuk Hariani Soekamto; Tjodi Harlim

doi:10.22146/ijc.21463

6,6’-DIMETHOXY-4,4’-DIHYDROXY-3’,2’-FURANO-ISOFLAVANE, A NEW COMPOUND FROM Melochia umbellata (Houtt.) Stapf var. Degrabrata K. (Paliasa)

https://doi.org/10.22146/ijc.21463

Erwin Erwin⁽¹⁾, Alfian Noor^(2*), Nunuk Hariani Soekamto⁽³⁾, Tjodi Harlim⁽⁴⁾

(1) Doctoral Programme in Chemistry, Post Graduate Programme, Hasanuddin University and Department of Chemistry, Mulawarman University, Kampus Gn. Kelua, 75123 Samarinda
(2) Department of Chemistry Hasanuddin University, Kampus UNHAS Tamalanrea, 90245 Makassar
(3) Department of Chemistry Hasanuddin University, Kampus UNHAS Tamalanrea, 90245 Makassar
(4) Department of Chemistry Hasanuddin University, Kampus UNHAS Tamalanrea, 90245 Makassar
(*) Corresponding Author

Abstract

Using data from UV, IR, ¹H-NMR, ¹³C-NMR, dan NMR-2D analysis, a compound of 6,6'-dimethoxy-4,4'-dihydroxy-3',2'-furano-isoflavane (1) was successfully isolated from chloroform fraction of heartwood in Melochia umbellata (Houtt.) Stapf var. Degrabarata K (Paliasa). Hitherto no report of such compound found in literature. The compound however has not shown a significant bioactivity according to either brine shrimp lethality test or evaluation of anti tumor activity against leukemia murine cell (P-388).

Keywords

isoflavane; heartwood; chloroform; Melochia umbellata

Full Text:

Full Text PDF

References

[1] Tjitrosoepomo, G, 2004, Taksonomi Tumbuhan (Spermatophyta), Gajah Mada University Press, Yokyakarta, 274-275.

[2] Raflizar, Adimunca, C., and Tuminah, S., 2006, Cermin Dunia Kedokteran, 50, 10-14.

[3] Erwin, Noor, A., Soekamto, N.H., and Harlim, Tj., 2009, Ind. Chim. Acta, 2, 1, 22-30.

[4] Erwin, Noor, A., Soekamto, N.H., and Harlim, Tj., 2009, Kimia Mulawarman, 6, 2,7-10.

[5] Erwin, Noor, A, Soekamto, N.H., and Harlim, Tj., 2009, Farmakologi Jurnal Farmasi, IV, 2, 51-55.

[6] Meyer, B.N., Ferrigny, N.R., Putnam, J.E., Jacobsen, L.B., Nicols, D.E., and McLaughlin, J.L., 1982, J. Med. Plant Res., 45, 31-34.

[7] Alley, M.C., Scudiero, D.A., Monks, A., Hursey, M.L., Czerwinksky, M.J., Fine, D.L., Abbott, B.J., Mayo, J.G., Shoemaker, R.H., and Boyd, M.R., 1988, Cancer Res., 48, 589-601.

DOI: https://doi.org/10.22146/ijc.21463