STRUCTURE ELUCIDATION OF ALKALOIDS FROM LEAVES OF Voacanga foetida (Bl.) Rolfe OF LOMBOK ISLAND

https://doi.org/10.22146/ijc.21460

Surya Hadi(1*), Dina Asnawati(2), Novi Febrianti(3)

(1) Study Program of Chemistry, Faculty of Mathematics and Natural Sciences, University of Mataram, Jl. Majapahit 62 Mataram-NTB 83125
(2) Study Program of Chemistry, Faculty of Mathematics and Natural Sciences, University of Mataram, Jl. Majapahit 62 Mataram-NTB 83125
(3) Study Program of Biology, Faculty of Mathematics and Natural Sciences, University of Mataram, Jl. Majapahit 62 Mataram-NTB 83125
(*) Corresponding Author

Abstract


The leaves of Voacanga foetida (Bl.) Rolfe, have been used ethnomedically for the treatment of wounds, itches, and swellings particularly in Lombok island. A phytochemical study has been done to investigate chemical compounds responsible against the cause of the diseases. By separating alkaloidal fraction from the leaves was found voacristine 1 as the major alkaloidal compound, and voacangine 2 and coronaridine 3 as the minor components. The structure elucidation of the compounds was carried out on the basis of spectroscopy data. A structure revision of voacristine 1 was also reported.


Keywords


alkaloids; Voacanga foetida; Lombok

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References

[1] Perry, L.M., and Metzger, J., 1980, Medicinal Plants of East and Southeast Asia: Attributed Properties and Uses, The MIT Press, Cambridge, 620

[2] Hadi, S., and Bremner J.B., 2001, Molecules, 6, 117-129.

[3] Bisset, N.G., 1958, Ann, Bogor, 3, 105-236.

[4] Southon, I.W., and Buckingham, J., 1989, Editors Dictionary of Alkaloids, Chapman and Hall 1230 p, Ltd, London, 1161.

[5] Renner, U., 1957, Experientia, 13, 468-469.

[6] Tantivatana, P., Ponglux, D., Wongseripipatana, S., and Phillipson, J.D., 1980, Planta Med., 40, 299-301.

[7] Gorman, M., Neuss, N., Cone, N.J., and Deyrup, J.A.,1960, J. Am. Chem. Soc., 82, 1142-1145.

[8] Van Beek, T.A., and Verpoorte, R., 1985, Fitoterapia, 56, 304-307.

[9] Govindachari, T.R., Joshi, B.S., Saksena, A.K., Sathe, S.S., and Viswanathan, N., 1965, Tetrahedron Lett., 3873-3878.

[10] Gunasekera, S.P., Cordell, G.A., and Farnsworth, N.R., 1980, Phytochem., 19, 1213-1218.

[11] Braga, R.M., and Reis, F. de A.M., 1987, Phytochem., 26, 833-836.

[12] Singbarti, G., Zetler, G., and Schlosser, L., 1973, Neuropharmacology, 12, 239-244.

[13] Rastogi, N., Abaul, J., Goh, K.S., Devallois, A., and Philogene, E., 1998, FEMS Immunol. Med. Microbiol., 20, 267-273.

[14] Okuyama, E., Gao, L.H., and Yamazaki, M., 1992, Chem. Pharm. Bull., 40, 2075-2079.

[15] Bert, M., Marcy, R., Quermonne, M.A., Cotelle, M., and Koch, M., 1988, Planta Med., 54, 191-192.

[16] Battersby, A.R., 1969, Biochem. J., 113, 26P-27P.

[17] Delorenzi, J.C., Attias, M., Gattass, C.R., Andrade, M., and Rezende, C., 2001. Antimicrob. Agents Chemother., 45, 1349-1354.

[18] Layer, R.T., Skolnick, P., Bertha, C.M., Bandarage, U.K., and Kuehne, M.E., 1996, Eur. J. Pharmacol., 309, 159-165.



DOI: https://doi.org/10.22146/ijc.21460

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