Radiochemical Separation of  161 Tb from Gd/Tb Matrix Using Ln Resin Column

Azmairit Aziz; Widya Tania Artha

doi:10.22146/ijc.21143

Radiochemical Separation of ¹⁶¹Tb from Gd/Tb Matrix Using Ln Resin Column

https://doi.org/10.22146/ijc.21143

Azmairit Aziz^(1*), Widya Tania Artha⁽²⁾

(1) Center for Nuclear Applied Science and Technology, National Nuclear Energy Agency, Jl. Tamansari 71 Bandung 40132
(2) Department of Chemistry, Faculty of Mathematics and Natural Sciences, Bandung Institute of Technology - ITB, Jl. Ganesha 10, Bandung 40132
(*) Corresponding Author

Abstract

Terbium-161 (¹⁶¹Tb) is a potential radiolanthanide due to its favorable properties for treatment small size of cancer. Preliminary study on radiochemical separation of ¹⁶¹Tb from Gd/Tb matrix using Ln resin column based on extraction chromatography method has been carried out. ¹⁶¹Tb radionuclide was produced by irradiation of natural Gd₂O₃ target through neutron thermal bombardment at G.A. Siwabessy Multipurpose Reactor. Fractions eluted from the column containing Gd/Tb matrix of irradiated natural Gd₂O₃ target were identified and quantified using a γ-rays spectrometer with HP-Ge detector coupled to a multichannel analyzer. The results show that the optimum condition on ¹⁶¹Tb separation from irradiated Gd₂O₃ target with radionuclide purity 99.27 ± 0.30% was obtained using HNO₃ solution with concentration of 0.8 and 3 N to separate gadolinium and terbium isotope, respectively. The yield of ¹⁶¹Tb obtained from the separation was 61.21 ± 2.05% and Gd recovered was 97.15 ± 2.23%. Based on this experiment, ¹⁶¹Tb has been separated from irradiated natural gadolinium oxide target with high radionuclide purity.

Keywords

radiolanthanide; terbium-161; carrier free; therapy; cancer

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DOI: https://doi.org/10.22146/ijc.21143