The Promoting Effects of 2, 3, 7, 8-Tetrachlorodibenzo-p-Dioxin on Nasal Tumors in Sprague-Dawley Rats

https://doi.org/10.22146/jifnp.20

R Wasito(1*)

(1) Gadjah Mada University
(*) Corresponding Author

Abstract


It was hypothesized that exposure to environmentally relevant dietary levels of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD) or 2, 2', 4, 4', 5, 5'-hexachlorobiphenyl (245- HCB) could cause the development of nasal tumors and a combined exposure to these compounds could have a potentiating effect on tumor development. Thirty days after partial hepatectomy and NDEA administration, groups of 12 or 24 female Sprague-Dawley rats were fed a basal diet or diets containing 10 ppt TCDD, 10 ppt TCDD, 5 ppm 245-HCB, 10 ppt TCDD and 245-HCB or 100 ppt TCDD and 245-HCB for 140 days. Basal diets were fed from day 140 unit rats were killed on day 210 or day 420. Results indicated that TCDD or a combination of TCDD and 245-HCB significantly increased the incidence of nasal tumors by day 420. However, a combined exposure to TCDD and 245-HCB had no potentiating effect on the incidence of nasal tumors.


Full Text:

PDF



DOI: https://doi.org/10.22146/jifnp.20

Article Metrics

Abstract views : 757 | views : 452

Refbacks

  • There are currently no refbacks.


Creative Commons License
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Indonesian Food and Nutrition Progress (print ISSN 0854-6177, online ISSN 2597-9388) is published by the Indonesian Association of Food Technologist in collaboration with Department of Food and Agricultural Product Technology, Faculty of Agricultural Technology, Universitas Gadjah Mada.

Journal of Indonesian Food and Nutrition Progress have been indexed by: 

   

 

This works is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.