New Valid and Reliable of Bahasa Version of QoL Instrument Based On The Health Condition: HRQ-6D
New valid and reliable Generic instrument of HRQoL
Keywords:
HR-QoL;, HRQ-6D;, Bahasa version;, Health condition, validity and reliability
Abstract
Health-related quality of life is very important to be measured as the parts of Patient-Reported Outcome (PRO). PRO can show the disease proression and also may influence the clinical decision making. There are many QoL instruments available in Indonesia as generic and specific instruments, however, there is no QoL instrument which measured the respondents’ functions based on the health status. This study is aimed to translate, adapt and validate the new QoL instrument based on the health condition, namely HRQ-6D (Health Related Quality of Life, 6 Dimensions). We conducted forward and backward translations. The subjects were people who lived in Yogyakarta city with aged more than 18 years old, and agreed to participate in this study. While the exclusion criteria were patients whose questionnaire data were incomplete. We shared the questionnaire to the area of Yogyakarta from September to October 2023. We used Pearson correlation, Cronbach alpha reliability test and Student T-test for the validity and reliability assessment.
We recruited 69 respondents with mostly female (60.9%) and the age is more than 60 yo (80.9%). Based on the health condition, more than fifty percent of the subjects (59.4%) were in Category 1, which considered as healthy, and only one subject were having more than one disease and have been hospitalized more than three times due to the disease or the complications (Category 4). The reliability test showed the Cronbach alpha value between 0.60-0.75. And all of the items in the questionnaire met the convergent and discriminant validity.
TheHRQ-6D can be implemented as the new Bahasa Version of QoL instrument, supported with the validity and reliability assessment.
References
Adnan, A., Perwitasari, D. A., & Mulyani, U. A. (2014). Reliability and Validaty of St George Respiratory Questionnaire (SGRQ) into Indonesian Version. International Journal of Public Health Science (IJPHS), 3(3), 179. https://doi.org/10.11591/.v3i3.4691
Bujang, M. A., Lai, W. H., Ratnasingam, S., Tiong, X. T., Hon, Y. K., Yap, E. P. P., Jee, Y. Y. H., Ahmad, N. F. D., Kim, A. R. J., Husin, M., & Haniff, J. (2023). Development of a Quality-of-Life Instrument to Measure Current Health Outcomes: Health-Related Quality of Life with Six Domains (HRQ-6D). Journal of Clinical Medicine, 12(8), 2816. https://doi.org/10.3390/jcm12082816
Cheung, G. W., Cooper-Thomas, H. D., Lau, R. S., & Wang, L. C. (2023). Reporting reliability, convergent and discriminant validity with structural equation modeling: A review and best-practice recommendations. Asia Pacific Journal of Management. https://doi.org/10.1007/s10490-023-09871-y
Cohen, S., van Dyck, C. H., Gee, M., Doherty, T., Kanekiyo, M., Dhadda, S., Li, D., Hersch, S., Irizarry, M., & Kramer, L. D. (2023). Lecanemab Clarity AD: Quality-of-Life Results from a Randomized, Double-Blind Phase 3 Trial in Early Alzheimer’s Disease. The Journal of Prevention of Alzheimer’s Disease. https://doi.org/10.14283/jpad.2023.123
Fletcher, B. R., Damery, S., Aiyegbusi, O. L., Anderson, N., Calvert, M., Cockwell, P., Ferguson, J., Horton, M., Paap, M. C. S., Sidey-Gibbons, C., Slade, A., Turner, N., & Kyte, D. (2022). Symptom burden and health-related quality of life in chronic kidney disease: A global systematic review and meta-analysis. PLOS Medicine, 19(4), e1003954. https://doi.org/10.1371/journal.pmed.1003954
Han, C. J., Rosko, A. E., Spakowicz, D. J., Hammer, M. J., & Von Ah, D. (2024). Associations of frailty with symptoms, and HRQOL in older cancer survivors after cancer treatments: a systematic review and meta-analyses. Quality of Life Research, 33(3), 583–598. https://doi.org/10.1007/s11136-023-03537-4
Haraldstad, K., Wahl, A., Andenæs, R., Andersen, J. R., Andersen, M. H., Beisland, E., Borge, C. R., Engebretsen, E., Eisemann, M., Halvorsrud, L., Hanssen, T. A., Haugstvedt, A., Haugland, T., Johansen, V. A., Larsen, M. H., Løvereide, L., Løyland, B., Kvarme, L. G., Moons, P., … Helseth, S. (2019). A systematic review of quality of life research in medicine and health sciences. Quality of Life Research, 28(10), 2641–2650. https://doi.org/10.1007/s11136-019-02214-9
Kheir, N. M., Foppe van Mil, J. W., Shaw, J. P., & Sheridan, J. L. (2004). Health-related quality of life measurement in pharmaceutical care Targeting an outcome that matters. Pharmacy World & Science, 26(3), 125–128. https://doi.org/10.1023/B:PHAR.0000026811.37414.4f
Koller, M., Aaronson, N. K., Blazeby, J., Bottomley, A., Dewolf, L., Fayers, P., Johnson, C., Ramage, J., Scott, N., & West, K. (2007). Translation procedures for standardised quality of life questionnaires: The European Organisation for Research and Treatment of Cancer (EORTC) approach. European Journal of Cancer, 43(12), 1810–1820. https://doi.org/10.1016/j.ejca.2007.05.029
Krabbe, P. (2016). The measurement of health and health status: Concepts, methods, and applications from a multidisclipinary perpective . J. S. Bentley (Ed.). Reed/ Elsevier.
Novitasari, L., Khoirunisa, S., Perwitasar, D.A. (2016). Validity of Short Form 36 (SF-36) Indonesian version on rheumatoid arthritis patients. Jurnal Kedokteran dan Kesehatan Indonesia, 7(3), 80-86
Pequeno, N. P. F., Cabral, N. L. de A., Marchioni, D. M., Lima, S. C. V. C., & Lyra, C. de O. (2020). Quality of life assessment instruments for adults: a systematic review of population-based studies. Health and Quality of Life Outcomes, 18(1), 208. https://doi.org/10.1186/s12955-020-01347-7
Perwitasari, D. A., Atthobari, J., Dwiprahasto, I., Hakimi, M., Gelderblom, H., Putter, H., Nortier, J. W. R., Guchelaar, H.-J., & Kaptein, A. A. (2011). Translation and Validation of EORTC QLQ-C30 into Indonesian Version for Cancer Patients in Indonesia. Japanese Journal of Clinical Oncology, 41(4), 519–529. https://doi.org/10.1093/jjco/hyq243
Purba, F. D., Hunfeld, J. A. M., Iskandarsyah, A., Fitriana, T. S., Sadarjoen, S. S., Ramos-Goñi, J. M., Passchier, J., & Busschbach, J. J. V. (2017). The Indonesian EQ-5D-5L Value Set. PharmacoEconomics, 35(11), 1153–1165. https://doi.org/10.1007/s40273-017-0538-9
Ranganathan, P., Caduff, C., & Frampton, C. M. A. (2024). Designing and validating a research questionnaire - Part 2. Perspectives in Clinical Research, 15(1), 42–45. https://doi.org/10.4103/picr.picr_318_23
Rautenberg, T., Hodgkinson, B., Zerwes, U., & Downes, M. (2022). Meta-analysis of health state utility values measured by EuroQol 5-dimensions (EQ5D) questionnaire in Chinese women with breast cancer. BMC Cancer, 22(1), 52. https://doi.org/10.1186/s12885-021-09140-5
Rachmawati, Y., Perwitasari, D.A., Adnan, A. Validasi Kuesioner SF-36 versi Indonesia terhadap pasien hipertensi di Puskesmas Yoyakarta. Pharmacy, 11(1),14-125
Sabaan, W., & Perwitasari, D. A. (2016). KUALITAS HIDUP POPULASI NORMAL DI KOTA YOGYAKARTA MENGGUNAKAN KUISIONER SF-36. Media Farmasi: Jurnal Ilmu Farmasi, 13(2), 261. https://doi.org/10.12928/mf.v13i2.7777
Schaafsma, J. (2005). The Case for Stratified Cost-Effectiveness Analysis by Baseline Health-Related QOL. PharmacoEconomics, 23(2), 121–132. https://doi.org/10.2165/00019053-200523020-00004
Skevington, S. M., Lotfy, M., & O’Connell, K. A. (2004). The World Health Organization’s WHOQOL-BREF quality of life assessment: Psychometric properties and results of the international field trial. A Report from the WHOQOL Group. Quality of Life Research, 13(2), 299–310. https://doi.org/10.1023/B:QURE.0000018486.91360.00
Staquet, M., Berzon, R., Osoba, D., & Machin, D. (1996). Guidelines for reporting results of quality of life assessments in clinical trials. Quality of Life Research, 5(5), 496–502. https://doi.org/10.1007/BF00540022
Van Griethuijsen, R. A. L. F., van Eijck, M. W., Haste, H., den Brok, P. J., Skinner, N. C., Mansour, N., Savran Gencer, A., & BouJaoude, S. (2015). Global Patterns in Students’ Views of Science and Interest in Science. Research in Science Education, 45(4), 581–603. https://doi.org/10.1007/s11165-014-9438-6
Wang, L, Polder, T.G. (2023). A systematic review of SF-6D health state valuation study. Journal of Medical Economics, 26(1), 584-593
Bujang, M. A., Lai, W. H., Ratnasingam, S., Tiong, X. T., Hon, Y. K., Yap, E. P. P., Jee, Y. Y. H., Ahmad, N. F. D., Kim, A. R. J., Husin, M., & Haniff, J. (2023). Development of a Quality-of-Life Instrument to Measure Current Health Outcomes: Health-Related Quality of Life with Six Domains (HRQ-6D). Journal of Clinical Medicine, 12(8), 2816. https://doi.org/10.3390/jcm12082816
Cheung, G. W., Cooper-Thomas, H. D., Lau, R. S., & Wang, L. C. (2023). Reporting reliability, convergent and discriminant validity with structural equation modeling: A review and best-practice recommendations. Asia Pacific Journal of Management. https://doi.org/10.1007/s10490-023-09871-y
Cohen, S., van Dyck, C. H., Gee, M., Doherty, T., Kanekiyo, M., Dhadda, S., Li, D., Hersch, S., Irizarry, M., & Kramer, L. D. (2023). Lecanemab Clarity AD: Quality-of-Life Results from a Randomized, Double-Blind Phase 3 Trial in Early Alzheimer’s Disease. The Journal of Prevention of Alzheimer’s Disease. https://doi.org/10.14283/jpad.2023.123
Fletcher, B. R., Damery, S., Aiyegbusi, O. L., Anderson, N., Calvert, M., Cockwell, P., Ferguson, J., Horton, M., Paap, M. C. S., Sidey-Gibbons, C., Slade, A., Turner, N., & Kyte, D. (2022). Symptom burden and health-related quality of life in chronic kidney disease: A global systematic review and meta-analysis. PLOS Medicine, 19(4), e1003954. https://doi.org/10.1371/journal.pmed.1003954
Han, C. J., Rosko, A. E., Spakowicz, D. J., Hammer, M. J., & Von Ah, D. (2024). Associations of frailty with symptoms, and HRQOL in older cancer survivors after cancer treatments: a systematic review and meta-analyses. Quality of Life Research, 33(3), 583–598. https://doi.org/10.1007/s11136-023-03537-4
Haraldstad, K., Wahl, A., Andenæs, R., Andersen, J. R., Andersen, M. H., Beisland, E., Borge, C. R., Engebretsen, E., Eisemann, M., Halvorsrud, L., Hanssen, T. A., Haugstvedt, A., Haugland, T., Johansen, V. A., Larsen, M. H., Løvereide, L., Løyland, B., Kvarme, L. G., Moons, P., … Helseth, S. (2019). A systematic review of quality of life research in medicine and health sciences. Quality of Life Research, 28(10), 2641–2650. https://doi.org/10.1007/s11136-019-02214-9
Kheir, N. M., Foppe van Mil, J. W., Shaw, J. P., & Sheridan, J. L. (2004). Health-related quality of life measurement in pharmaceutical care Targeting an outcome that matters. Pharmacy World & Science, 26(3), 125–128. https://doi.org/10.1023/B:PHAR.0000026811.37414.4f
Koller, M., Aaronson, N. K., Blazeby, J., Bottomley, A., Dewolf, L., Fayers, P., Johnson, C., Ramage, J., Scott, N., & West, K. (2007). Translation procedures for standardised quality of life questionnaires: The European Organisation for Research and Treatment of Cancer (EORTC) approach. European Journal of Cancer, 43(12), 1810–1820. https://doi.org/10.1016/j.ejca.2007.05.029
Krabbe, P. (2016). The measurement of health and health status: Concepts, methods, and applications from a multidisclipinary perpective . J. S. Bentley (Ed.). Reed/ Elsevier.
Novitasari, L., Khoirunisa, S., Perwitasar, D.A. (2016). Validity of Short Form 36 (SF-36) Indonesian version on rheumatoid arthritis patients. Jurnal Kedokteran dan Kesehatan Indonesia, 7(3), 80-86
Pequeno, N. P. F., Cabral, N. L. de A., Marchioni, D. M., Lima, S. C. V. C., & Lyra, C. de O. (2020). Quality of life assessment instruments for adults: a systematic review of population-based studies. Health and Quality of Life Outcomes, 18(1), 208. https://doi.org/10.1186/s12955-020-01347-7
Perwitasari, D. A., Atthobari, J., Dwiprahasto, I., Hakimi, M., Gelderblom, H., Putter, H., Nortier, J. W. R., Guchelaar, H.-J., & Kaptein, A. A. (2011). Translation and Validation of EORTC QLQ-C30 into Indonesian Version for Cancer Patients in Indonesia. Japanese Journal of Clinical Oncology, 41(4), 519–529. https://doi.org/10.1093/jjco/hyq243
Purba, F. D., Hunfeld, J. A. M., Iskandarsyah, A., Fitriana, T. S., Sadarjoen, S. S., Ramos-Goñi, J. M., Passchier, J., & Busschbach, J. J. V. (2017). The Indonesian EQ-5D-5L Value Set. PharmacoEconomics, 35(11), 1153–1165. https://doi.org/10.1007/s40273-017-0538-9
Ranganathan, P., Caduff, C., & Frampton, C. M. A. (2024). Designing and validating a research questionnaire - Part 2. Perspectives in Clinical Research, 15(1), 42–45. https://doi.org/10.4103/picr.picr_318_23
Rautenberg, T., Hodgkinson, B., Zerwes, U., & Downes, M. (2022). Meta-analysis of health state utility values measured by EuroQol 5-dimensions (EQ5D) questionnaire in Chinese women with breast cancer. BMC Cancer, 22(1), 52. https://doi.org/10.1186/s12885-021-09140-5
Rachmawati, Y., Perwitasari, D.A., Adnan, A. Validasi Kuesioner SF-36 versi Indonesia terhadap pasien hipertensi di Puskesmas Yoyakarta. Pharmacy, 11(1),14-125
Sabaan, W., & Perwitasari, D. A. (2016). KUALITAS HIDUP POPULASI NORMAL DI KOTA YOGYAKARTA MENGGUNAKAN KUISIONER SF-36. Media Farmasi: Jurnal Ilmu Farmasi, 13(2), 261. https://doi.org/10.12928/mf.v13i2.7777
Schaafsma, J. (2005). The Case for Stratified Cost-Effectiveness Analysis by Baseline Health-Related QOL. PharmacoEconomics, 23(2), 121–132. https://doi.org/10.2165/00019053-200523020-00004
Skevington, S. M., Lotfy, M., & O’Connell, K. A. (2004). The World Health Organization’s WHOQOL-BREF quality of life assessment: Psychometric properties and results of the international field trial. A Report from the WHOQOL Group. Quality of Life Research, 13(2), 299–310. https://doi.org/10.1023/B:QURE.0000018486.91360.00
Staquet, M., Berzon, R., Osoba, D., & Machin, D. (1996). Guidelines for reporting results of quality of life assessments in clinical trials. Quality of Life Research, 5(5), 496–502. https://doi.org/10.1007/BF00540022
Van Griethuijsen, R. A. L. F., van Eijck, M. W., Haste, H., den Brok, P. J., Skinner, N. C., Mansour, N., Savran Gencer, A., & BouJaoude, S. (2015). Global Patterns in Students’ Views of Science and Interest in Science. Research in Science Education, 45(4), 581–603. https://doi.org/10.1007/s11165-014-9438-6
Wang, L, Polder, T.G. (2023). A systematic review of SF-6D health state valuation study. Journal of Medical Economics, 26(1), 584-593
Published
2025-02-12
How to Cite
Noor Faridah, I., Dyah Aryani Perwitasari, Dania, H., & Bujang, M. A. (2025). New Valid and Reliable of Bahasa Version of QoL Instrument Based On The Health Condition: HRQ-6D. Indonesian Journal of Pharmacy. https://doi.org/10.22146/ijp.13905
Issue
Section
Articles
