Isolation and caracterization of Zerumbone isolated from Zingiber zerumbet
Keywords:
Zerumbone, Lempuyang wangi, Isolation
Abstract
Zerumbone is a cyclic sesquiterpene compound which is the main content of ethanol extract and lempuyang essential oil (Zingiber zerumbet). Zerumbone has been studied as a potential anticancer agent because it induces apoptosis and cycle inhibition while inhibiting invasion and metastasis. This research aims to isolate zerumbone from lempuyang wangi (Zingiber zerumbet) extract. The method used in this research includes isolation using column chromatography which allows a compound to be obtained in quite large quantities. Monitoring of the isolate extract was analyzed using Thin Layer Chromatography (TLC) under a UV lamp, monitoring of the isolate fraction using TLC under a UV lamp, then testing the purity of the zerumbone isolate using the UV-Vis spectrophotometer method, IR (Infrared) spectroscopy, TLC with different eluents , and LC-MS/MS, obtained the same compound isolation results between the isolate and the zerumbone standard with high purity, with a yield of 11% isolate.
References
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Jorvig, J.E., Chakraborty, A., 2015. Zerumbone inhibits growth of hormone refractory prostate cancer cells by inhibiting JAK2/STAT3 pathway and increases paclitaxel sensitivity. Anticancer Drugs 26, 160–166. doi:10.1097/CAD.0000000000000171
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Published
2025-04-25
How to Cite
Riri Fauziyya, Winni Nur Auli, Nisa Yulianti Suprahman, sarmoko, Arif Ashar, Anjar Hermadi Saputro, Qurrota A’yun Azzahrah, Dinda Naila Dhiya Salsabila, Ihza Adzkiya Mubarak Al-Husni, Putri Liswatini, & Romualdo Pasaribu. (2025). Isolation and caracterization of Zerumbone isolated from Zingiber zerumbet. Indonesian Journal of Pharmacy. https://doi.org/10.22146/ijp.12607
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Research Article
