The Effect of Curcumin Adjuvant Therapy on Pulmonary Function and Levels of Interleukin-6 (IL-6) and Superoxide Dismutase-3 (EC-SOD3) in Patients with Chronic Bronchial Asthma
Keywords:
chronic bronchial asthma, pulmonary function, curcumin supplement, interleukin-6
Abstract
This study was designed to evaluate the effectiveness of curcumin supplement as antioxidant and anti-inflammatory in patients with chronic bronchial asthma. Forty patients diagnosed with chronic bronchial asthma were enrolled in this study and allocated into group (1) patients assigned to receive conventional therapy of asthma, and group (2) patient assigned to receive conventional therapy of asthma combined with 750 mg curcumin supplement twice daily for two months. Pulmonary function test, asthma control test, serum interleukin-6 and serum extracellular super oxide dismutase 3 were measured before and after two months in both study groups. After two months, the mean values of pulmonary function test (spirometry) and asthma control score showed significant increase compared to pre-treatment values in group 2 patients (P<0.01). Moreover, there was marked decrease in the level of interleukin-6 in group 2 patients after two months (p< 0.05) compared to the increased in group 1 patients. The mean level of super oxide dismutase 3 didn’t show any increase in both study groups after treatment. Curcumin supplement produced improvement in pulmonary function of patients with chronic bronchial asthma along with the reduction in inflammatory status. No change in endogenous oxidative status after curcumin supplementation.
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Zeng, X., Cheng, Y., Qu, Y., Xu, J., Han, Z., & Zhang, T. (2013). Curcumin inhibits the proliferation of airway smooth muscle cells in vitro and in vivo. International journal of molecular medicine, 32(3), 629-636.
Abbas, S. H., Abdulridha, M. K., & Najeb, A. A. (2018). Response to Helicobacter pylori Eradication Triple Therapy in Peptic Ulcer Disease Patients on Curcumin Supplement According to different ABO Phenotypes. karbala journal of pharmaceutical sciences(15), 11-31.
Abidi, A., Gupta, S., Agarwal, M., Bhalla, H. L., & Saluja, M. (2014). Evaluation of Efficacy of Curcumin as an Add-on therapy in Patients of Bronchial Asthma. J Clin Diagn Res, 8(8), Hc19-24. doi:10.7860/jcdr/2014/9273.4705
Ahmed, S. A. (2016). Assessment the severity of asthma on patients in specialist respiratory center in Baghdad city. kufa Journal for Nursing sciences, 6(1), 139-145.
Alsamarai, A. M., Salih, M. A., Alobaidy, A. H., Alwan, A. M., & Abdulaziz, Z. H. (2009). Risk factors for asthma in Iraqi children. Journal of Rural and Tropical Public Health, 8, 45-52.
Baldaçara, R. P. d. C., & Silva, I. (2017). Association between asthma and female sex hormones. Sao Paulo Medical Journal, 135(1), 4-14.
Comhair, S. A., & Erzurum, S. C. (2010). Redox control of asthma: molecular mechanisms and therapeutic opportunities. Antioxidants & redox signaling, 12(1), 93-124.
Comhair, S. A., Xu, W., Ghosh, S., Thunnissen, F. B., Almasan, A., Calhoun, W. J., . . . Erzurum, S. C. (2005). Superoxide dismutase inactivation in pathophysiology of asthmatic airway remodeling and reactivity. The American journal of pathology, 166(3), 663-674.
Expert Panel Report 3: Guidelines for the Diagnosis and Management of Asthma. (US). (2007
). Retrieved from usa:
Fadus, M. C., Lau, C., Bikhchandani, J., & Lynch, H. T. (2017). Curcumin: An age-old anti-inflammatory and anti-neoplastic agent. J Tradit Complement Med, 7(3), 339-346. doi:10.1016/j.jtcme.2016.08.002
Jusufovic, E., Kosnik, M., Jusufovic, A., Becarevic, M., Al-Ahmad, M., Nurkic, J., . . . Halilovic, D. (2017). Curcumin as an add-on therapy of moderate partially controlled asthma. Eur Respir J, 50, 442.
Karaman, M., Firinci, F., Cilaker, S., Uysal, P., Tugyan, K., Yilmaz, O., . . . Karaman, O. (2012). Anti-inflammatory effects of curcumin in a murine model of chronic asthma. Allergologia et Immunopathologia, 40(4), 210-214.
Khdair, S. A., Abdulridha, M. K., & Fatah, M. A. (2019). Effect of Curcumin Supplement on Pulmonary Functions, Total and Differential White Blood Cell Count, Serum Level of Leptin and Body Mass Index in a Sample of Iraqi Patients with Chronic Bronchial Asthma. Al-Mustansiriyah Journal of Pharmaceutical Sciences (AJPS), 19(2), 47-58.
Kim, D. H., Phillips, J. F., & Lockey, R. F. (2011). Oral curcumin supplementation in patients with atopic asthma. Allergy & rhinology, 2(2), ar. 2011.2012. 0016.
Kishimoto, T. (2010). IL-6: from its discovery to clinical applications. International immunology, 22(5), 347-352.
Kurup, V. P., & Barrios, C. S. (2008). Immunomodulatory effects of curcumin in allergy. Mol Nutr Food Res, 52(9), 1031-1039. doi:10.1002/mnfr.200700293
Lajunen, T. K., Jaakkola, J. J., & Jaakkola, M. S. (2013). Influence of heredity on asthma continues to adulthood. Journal of Allergy and Clinical Immunology, 131(3), 916-918. e913.
Lelli D, S. A., Johnston TP, Pedone C. (2017 Jan). . Curcumin use in pulmonary diseases: State of the art and future perspectives. ;. Pharmacol Res., 115:133-148.
Mirabelli, M. C., Beavers, S. F., Chatterjee, A. B., & Moorman, J. E. (2013). Age at asthma onset and subsequent asthma outcomes among adults with active asthma. Respiratory medicine, 107(12), 1829-1836.
Ng, T. P., Niti, M., Yap, K. B., & Tan, W. C. (2012). Curcumins-rich curry diet and pulmonary function in Asian older adults. PLoS One, 7(12), e51753.
Panahi, Y., Ghanei, M., Hajhashemi, A., & Sahebkar, A. (2016). Effects of Curcuminoids-Piperine Combination on Systemic Oxidative Stress, Clinical Symptoms and Quality of Life in Subjects with Chronic Pulmonary Complications Due to Sulfur Mustard: A Randomized Controlled Trial. J Diet Suppl, 13(1), 93-105. doi:10.3109/19390211.2014.952865
Panahi, Y., Khalili, N., Sahebi, E., Namazi, S., Karimian, M. S., Majeed, M., & Sahebkar, A. (2017). Antioxidant effects of curcuminoids in patients with type 2 diabetes mellitus: a randomized controlled trial. Inflammopharmacology, 25(1), 25-31.
Peters, M. C., McGrath, K. W., Hawkins, G. A., Hastie, A. T., Levy, B. D., Israel, E., . . . Erzurum, S. C. (2016). Plasma interleukin-6 concentrations, metabolic dysfunction, and asthma severity: a cross-sectional analysis of two cohorts. The Lancet Respiratory Medicine, 4(7), 574-584.
Rincon, M., & Irvin, C. G. (2012). Role of IL-6 in asthma and other inflammatory pulmonary diseases. International journal of biological sciences, 8(9), 1281.
Self TH, C. C., Finch CK. (2013. ). Asthma. In: Alldredge BK, Corelli RL, Ernst ME, Guglielmo BJ, Jacobson PA, Kradjan WA, et al. Koda-Kimble and Young’s Applied Therapeutics: The Clinical Use of Drugs. 10th ed. Philadelphia, PA: Lippincott Williams and Wilkins; .
Shakeri, F., Roshan, N. M., Kaveh, M., Eftekhar, N., & Boskabady, M. H. (2018). Curcumin affects tracheal responsiveness and lung pathology in asthmatic rats. Pharmacol Rep, 70(5), 981-987. doi:10.1016/j.pharep.2018.04.007
Smith, M. R., Gangireddy, S. R., Narala, V. R., Hogaboam, C. M., Standiford, T. J., Christensen, P. J., . . . Reddy, R. C. (2010). Curcumin inhibits fibrosis-related effects in IPF fibroblasts and in mice following bleomycin-induced lung injury. Am J Physiol Lung Cell Mol Physiol, 298(5), L616-625. doi:10.1152/ajplung.00002.2009
Tabrizi, R., Vakili, S., Akbari, M., Mirhosseini, N., Lankarani, K. B., Rahimi, M., . . . Asemi, Z. (2019). The effects of curcumin‐containing supplements on biomarkers of inflammation and oxidative stress: A systematic review and meta‐analysis of randomized controlled trials. Phytotherapy Research, 33(2), 253-262.
Tyagi, N., Kumari, A., Dash, D., & Singh, R. (2014). Protective effects of intranasal curcumin on paraquot induced acute lung injury (ALI) in mice. Environ Toxicol Pharmacol, 38(3), 913-921. doi:10.1016/j.etap.2014.10.003
Xu, F., Diao, R., Liu, J., Kang, Y., Wang, X., & Shi, L. (2015). Curcumin attenuates staphylococcus aureus-induced acute lung injury. Clin Respir J, 9(1), 87-97. doi:10.1111/crj.12113
Zein, J. G., & Erzurum, S. C. (2015). Asthma is Different in Women. Curr Allergy Asthma Rep, 15(6), 28. doi:10.1007/s11882-015-0528-y
Zeng, X., Cheng, Y., Qu, Y., Xu, J., Han, Z., & Zhang, T. (2013). Curcumin inhibits the proliferation of airway smooth muscle cells in vitro and in vivo. International journal of molecular medicine, 32(3), 629-636.
Published
2021-04-01
How to Cite
Khdair, S. A., Abdulridha, M. K., & Shafek, M. A. (2021). The Effect of Curcumin Adjuvant Therapy on Pulmonary Function and Levels of Interleukin-6 (IL-6) and Superoxide Dismutase-3 (EC-SOD3) in Patients with Chronic Bronchial Asthma. Indonesian Journal of Pharmacy, 32(2), 232-240. https://doi.org/10.22146/ijp.1136
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