Hollow Fiber Hemodialysis Imprinted Membrane Based on Eugenol for Human Blood Filter

Muhammad Cholid Djunaidi; Nesti Dwi Maharani; Pardoyo Pardoyo; Yanuardi Raharjo

doi:10.22146/ijc.83065

Hollow Fiber Hemodialysis Imprinted Membrane Based on Eugenol for Human Blood Filter

https://doi.org/10.22146/ijc.83065

Muhammad Cholid Djunaidi^(1*), Nesti Dwi Maharani⁽²⁾, Pardoyo Pardoyo⁽³⁾, Yanuardi Raharjo⁽⁴⁾

(1) Department of Chemistry, Faculty of Science and Mathematics, Diponegoro University, Jl. Prof. Soedharto SH, Tembalang, Semarang 50275, Indonesia
(2) Department of Chemistry, Faculty of Science and Mathematics, Diponegoro University, Jl. Prof. Soedharto SH, Tembalang, Semarang 50275, Indonesia
(3) Department of Chemistry, Faculty of Science and Mathematics, Diponegoro University, Jl. Prof. Soedharto SH, Tembalang, Semarang 50275, Indonesia
(4) Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Campus C, Mulyorejo, Surabaya 60115, Indonesia
(*) Corresponding Author

Abstract

Kidney failure is a kidney function disorder that occurs in more than 90.00% of people in the world, especially in developing countries. In 2013, around 12.50% of the 25 million population experienced kidney failure and 78.00% had to undergo dialysis for life. In this research, a hemodialysis method was developed, namely molecularly imprinted membrane (MIM), which has high selectivity for urea molecules with high binding capacity using a membrane in the form of hollow fiber. Variations in research use urea transport concentrations such as 50, 200, and 300 ppm. The analysis using UV-vis spectrophotometry on HFHIM with a solution mixture of 50 ppm showed that the receiving phase by the membrane was 70.48% urea, 12.97% creatinine, and 9.42% vitamin B₁₂. Meanwhile, the feed phase is 28.25% urea, 85.41% creatinine and 88.64% vitamin B₁₂. When using HFHNIM, the receiving phase is urea 44.78%, creatinine 58.51%, and vitamin B₁₂ 31.00%. Meanwhile, the feed phase is 54.55% urea, 40.57% creatinine, 68.29% vitamin B₁₂. The selectivity of HFHIM for urea is better than creatinine and vitamin B₁₂ compared to HFHNIM, in the order of selectivity urea > creatinine > vitamin B₁₂.

Keywords

polyeugenol; imprinted; hollow fiber; hemodialysis

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DOI: https://doi.org/10.22146/ijc.83065