Synthesis, Structural Determination and Antibacterial Properties of Zinc(II) Complexes Containing 4-Aminopyridine Ligands

https://doi.org/10.22146/ijc.82801

I Wayan Dasna(1*), Dewi Mariyam(2), Husni Wahyu Wijaya(3), Ubed Sonai Fahruddin Arrozi(4), Sugiarto Sugiarto(5)

(1) Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Negeri Malang, Jl. Semarang No. 5, Malang 65145, East Java, Indonesia; Center of Advanced Material for Renewable Energy, Universitas Negeri Malang, Jl. Semarang No. 5, Malang 65145, East Java, Indonesia
(2) Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Negeri Malang, Jl. Semarang No. 5, Malang 65145, East Java, Indonesia
(3) Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Negeri Malang, Jl. Semarang No. 5, Malang 65145, East Java, Indonesia; Center of Advanced Material for Renewable Energy, Universitas Negeri Malang, Jl. Semarang No. 5, Malang 65145, East Java, Indonesia
(4) Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Negeri Malang, Jl. Semarang No. 5, Malang 65145, East Java, Indonesia
(5) Department of Applied Chemistry, Graduate School of Advanced Science and Engineering, Hiroshima University, 1-4-1 Kagamiyama, Higashi-Hiroshima 7398527, Japan
(*) Corresponding Author

Abstract


Three zinc(II) complexes containing 4-aminopyridine (4-NH2py) [Zn(4-NH2py)2(NCS)2] (1), [Zn(4-NH2py)2Cl2] (2), and [Zn(4-NH2py)2(NCS)Cl] (3) were synthesized and characterized by FTIR and single crystal X-ray diffraction. All complexes adopt a slightly distorted tetrahedral geometry with different crystal packing. Complex 1 crystallizes in the orthorhombic Pmmn space group, complex 2 in the monoclinic C2/c space group, and complex 3 in the orthorhombic Pbca space group. Non-covalent interactions such as NC-S···H, -Cl···H, and µ-µ stacking interaction between 4-NH2py and other ligands (NCS and Cl) are observed in the crystals packing. In vitro, antibacterial screening of all complexes was evaluated against two bacteria (Escherichia coli and Staphylococcus aureus). The results show that 1 has the highest antibacterial activity than 2 and 3. This difference is due to differences in the interactions elicited by the anion ligands.


Keywords


zinc(II) complexes; 4-NH2py; thiocyanato; chloro ligand; antibacterial activity

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DOI: https://doi.org/10.22146/ijc.82801

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