Synthesis of ZnO Nanoparticle and Utilized as a Drug Carrier to Treat Leukemia

Areej Ali Jarullah(1*), Nidhal Meteab Khamees(2), Taghreed Mohy Al-Deen Musa(3)

(1) Department of Chemistry, College of Science, University of Diyala, Baquba, Diyala, Iraq
(2) Department of Chemistry, College of Science, University of Diyala, Baquba, Diyala, Iraq
(3) Department of Chemistry, College of Science, Mustansiriyah University, Baghdad 10052, Iraq
(*) Corresponding Author


This study includes two parts, and the first was the preparation of the Zn(II)complex by reacting N-[4-(5-{(Z)-[(5-oxo-2-sulfanyl-4,5-dihydro-1H-imidazol-1-yl)imino]methyl}furan-2-yl)phenyl]acetamide with ZnCl2. The complex was characterized by using microscopic analysis such as UV-Vis spectrum, LC-MS, FTIR spectrophotometer, measurements of conductivity, magnetic susceptibility, and atomic absorption. The second part was the preparation of the ZnO nanoparticles by dissolving the Zn(II) complex in HNO3 and HCl and its use as a drug transporter to treat leukemia. FSEM, TEM, and XRD were examined for the characterization of ZnO nanoparticles that will be used in the synthesis of most medicines and drugs in the future.


zinc(II)complex; ZnO nanoparticles; carrier for anti-cancer drugs; leukemia; microscopic analysis

Full Text:

Full Text PDF


[1] Iqbal, A., Iqbal, K., Qin, W., and Mateen, M., 2019, Recent revolutions in nanoscience and nanotechnology with its application’s, Adv. Nanosci. Nanotechnol., 3 (3), 1–6.

[2] Huang, C., Chen, X., Xue, Z., and Wang, T., 2020, Effect of structure: A new insight into nanoparticle assemblies from inanimate to animate, Sci. Adv., 6 (20), eaba1321.

[3] Nazeruddin, G.M., Prasad, S.R., Shaikh, Y.I., and Prasad, N.R., 2015, A brief review: Science at nanoscale, Int. J. Nanomater. Nanostruct., 1 (1), 16–32.

[4] Richards, D.A., Maruani, A., and Chudasama, V., 2017, Antibody fragments as nanoparticle targeting ligands: A step in the light direction, Chem. Sci., 8 (1), 63–77.

[5] Pudlarz, A., and Szemraj, J., 2018, Nanoparticles as carriers of proteins, peptides and other therapeutic molecules, Open Life Sci., 13, 285–298.

[6] Lee, M., and Kim, S., 2005, Polyethylene glycol-conjugated copolymers for plasmid DNA delivery, Pharm. Res., 22 (1), 1–10.

[7] Hahn, Y.B., 2011, Zinc oxide nanostructures and their applications, Korean J. Chem. Eng., 28 (9), 1797–1813.

[8] Mirzaei, H., and Darroudi, M., 2017, Zinc oxide nanoparticles: Biological synthesis and biomedical applications, Ceram. Int., 43 (1, Part B), 907–914.

[9] Zhang, Y., Nayak, T.R., Hong, H., and Cai, W., 2013, Biomedical applications of zinc oxide nanomaterials, Curr. Mol. Med., 13 (10), 1633–1645.

[10] Mohd Yusof, H., Mohamad, R., Zaidan, U.H., and Abdul Rahman, N.A., 2019, Microbial synthesis of zinc oxide nanoparticles and their potential application as an antimicrobial agent and a feed supplement in animal industry: A review, J. Anim. Sci. Biotechnol., 10 (1), 57.

[11] Sirelkhatim, A., Mahmud, S., Seeni, A., Mohamad Kaus, N.H., Ann, L.C., Mohd Bakhori, S.K., Hasan, H., and Mohamad, D., 2015, Review on zinc oxide nanoparticles: Antibacterial activity and toxicity mechanism, Nano-Micro Lett., 7 (3), 219–242.

[12] Dozzo, A., Galvin, A., Shin, J.W., Scalia, S., O’Driscoll, C.M., and Ryan, K.B., 2023, Modelling acute myeloid leukemia (AML): What’s new? A transition from the classical to the modern, Drug Delivery Transl. Res., 13 (8), 2110–2141.

[13] Basu, J., Madhulika, S., Murmu, K.C., Mohanty, S., Samal, P., Das, A., Mahapatra, S., Saha, S., Sinha, I., and Prasad, P., 2023, Molecular and epigenetic alterations in normal and malignant myelopoiesis in human leukemia 60 (HL60) promyelocytic cell line model, Front. Cell Dev. Biol., 11, 1060537.

[14] Ward, H.A., Musa, T.M., and Nasif, Z.N., 2022, Synthesis and Characterization of some transition metals complexes with new ligand azo imidazole derivative, Al-Mustansiriyah J. Sci., 33 (2), 31–38.

[15] Budavari, S., 1996, The Merck Index: An Encyclopedia of Chemicals, Drugs, and Biologicals, 12th Ed., Merck, Whitehouse Station, New Jersey.

[16] Numan, A.T., Sanak, K.A., Atiyah, E.M., and Sadiq, S.A., 2015, Synthesis and characterization of new bidentate chalcone ligand type (NO) and its MnII, CoII, NiII and CuII complexes with study of their antibacterial activity, Diyala J. Pure Sci., 11 (3), 25–42.

[17] Al-Shemary, R.K.R., 2017, Microwave preparation, spectral studies and antimicrobial activities evaluation of Mn(II), Ni(II), Hg(II), Co(II) and Cu(II) complexes with Schiff base ligand, Ibn Al-Haitham J. Pure Appl. Sci., 30 (3), 58–67.

[18] Bader, A.T., Al-Abdaly, B.I., and Jassim I.K., 2019, Synthesis and characterization new metal complexes of heterocyclic units and study antibacterial and antifungal, J. Pharm. Sci. Res., 11 (5), 2062–2073

[19] Alias, M.F., and Seewan, A.N., 2013, Synthesis, spectral study, theoretical treatment and biological activity of some transition metal complexes with 2-amino acetic acid-6-chloro benzothiazole, Diyala J. Pure Sci., 9 (4), 93–103.

[20] Lateef, H.S., Jarullah, A.A., and Faraj, F.L., 2019, Cytotoxicity effecting of new ligand (LCl) and it's complexes on a breast cancer, Int. J. Pharm. Res., 11 (4), 1–10.

[21] Krug, H.F., and Wick, P., 2011, Nano toxicology: An interdisciplinary challenge, Angew. Chem., Int. Ed., 50 (6), 1260–1278.

[22] Kaur, G., Kaur, P., and Kaur, R., 2019, Quinoline: Its synthesis and pharmacological activities, Pramana Res. J., 9 (6), 1718–1748.


Article Metrics

Abstract views : 1322 | views : 666

Copyright (c) 2023 Indonesian Journal of Chemistry

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.


Indonesian Journal of Chemistry (ISSN 1411-9420 /e-ISSN 2460-1578) - Chemistry Department, Universitas Gadjah Mada, Indonesia.

Analytics View The Statistics of Indones. J. Chem.