Pharmacological Properties of Genista sagittalis L. (Fabaceae) Grown in Turkey

Pelin Şenel(1), Bleda Can Sadıkoğulları(2), Elif Çepni Yüzbaşıoğlu(3), Gülnur Mertoğlu Elmas(4), Dilek Oral(5), Ayşegül Gölcü(6), Ayşe Daut Özdemir(7*)

(1) Department of Chemistry, Faculty of Sciences and Letters, Istanbul Technical University, 34469 Istanbul, Turkey
(2) Department of Chemistry, Faculty of Sciences and Letters, Istanbul Technical University, 34469 Istanbul, Turkey
(3) Department of Molecular Biology and Genetics, Faculty of Science, Istanbul University, Vezneciler, 34134 Istanbul, Turkey
(4) Department of Forest Industrial Engineering, Forest Faculty, Istanbul University-Cerrahpasa, 34473 Istanbul, Turkey
(5) Department of Forest Botany, Forest Faculty, Istanbul University-Cerrahpasa, 34473 Istanbul, Turkey
(6) Department of Chemistry, Faculty of Sciences and Letters, Istanbul Technical University, 34469 Istanbul, Turkey
(7) Department of Chemistry, Faculty of Sciences and Letters, Istanbul Technical University, 34469 Istanbul, Turkey
(*) Corresponding Author


The genus Genista L. (Family: Fabaceae) is a plant having several traditional uses for treating common ailments such as diabetes, ulcer, and respiratory diseases. In this current study, the composition of essential oil and the biological activities of Genista sagittalis L. (Fabaceae) from Kocaeli: Yuvacık Dam Basin have been studied. A total of fourteen components were identified in the essential oil. The identified compounds belonged to straight-chain alkane, aromatic ether, and terpenoid derivatives. The antibacterial activity analyses demonstrated that G. sagittalis flower extract only had low activity against P. mirabilis and P. aeruginosa with MICs 1 to 2 mg/mL, as the peduncle extract showed strong anti-QS activity at 1.3 mg/mL. To the best of our knowledge, the current work is the first to report the antimicrobial and anti-quorum sensing activity of G. sagittalis growing in Turkey. Double-stranded DNA binding affinity investigations of the flower and peduncle ethanol extracts indicate that there are interactions with double-stranded DNA and related binding constants (Kb) were found as 1.97×103±0.37 and 3.68×102±0.44 for the flower and peduncle extract, respectively.


antibacterial; anti-quorum sensing; DNA binding; Fabaceae; Genista sagittalis; plant extracts

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