Microstructural Analysis and Antibacterial Response of Zn2+/Mg2+ Dual Doped β-Tricalcium Phosphate Bioceramics

https://doi.org/10.22146/ijc.72286

Ammar Zeidan Alshemary(1*), Huda Basim Qasim(2), Ali Taha Saleh(3)

(1) Department of Biomedical Engineering, Faculty of Engineering, Karabuk University, Karabuk 78050, Turkey Biomedical Engineering Department, Al-Mustaqbal University College, Hillah, Babil 51001, Iraq
(2) Al-Manara College for Medical Sciences, Misan 62001, Iraq
(3) Department of Chemistry, College of Science, University of Misan, Misan 62001, Iraq
(*) Corresponding Author

Abstract


This article evaluates the impact of the addition of zinc (Zn) and magnesium (Mg) on the structural, morphological, and antibacterial characteristics of β-tricalcium phosphates (hereafter called Zn/Mg-βTCP) prepared using the microwave (MW) assisted wet precipitation method in which the Ca deficient apatite [Ca9-(x+y)MgxZny(HPO4)(PO4)5 (OH)] was calcined for 2 h at 1000 °C. The prepared samples were characterized using XRD, FTIR, and FESEM measurements. The XRD patterns of the samples showed a steady decrease in the lattice parameters with an increase in Mg2+ and Zn2+ content. The FESEM images of the samples disclosed the morphological changes due to the Mg2+/Zn2+ co-doping. The inclusion of Mg2+ and Zn2+ into the βTCP was shown to induce excellent bioactivities that were absent in the pristine βTCP. Enhancement, coupled with good antimicrobial properties against Escherichia coli (E. coli), suggests that Mg2+/Zn2+ co-doping TCP can be developed further into antibacterial bone cement. As synthesized, it would be considered a potential biomaterial for orthopedic applications.


Keywords


β-tricalcium phosphates; Co-doping; microstructure; phase purity; antibacterial

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DOI: https://doi.org/10.22146/ijc.72286

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