Synthesis and Cytotoxic Test of Halogen-Substituted Chalcone Against MCF-7 Breast Cancer Cells

https://doi.org/10.22146/ijc.69991

Eti Meirina Brahmana(1), Jamaran Kaban(2*), Ginda Haro(3), Mimpin Ginting(4)

(1) Postgraduate School, Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Sumatera Utara, Jl. Bioteknologi No. 1, Medan 20155, Indonesia; Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Sumatera Utara, Jl. Bioteknologi No. 1, Medan 20155, Indonesia; Biology Study Program, Faculty of Teaching Training and Education, Universitas Pasir Pengaraian, Riau 28557, Indonesia
(2) Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Sumatera Utara, Jl. Bioteknologi No. 1, Medan 20155, Indonesia
(3) Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Universitas Sumatera Utara, Jl. Tri Dharma No. 5, Medan 20155, Indonesia
(4) Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Sumatera Utara, Jl. Bioteknologi No. 1, Medan 20155, Indonesia
(*) Corresponding Author

Abstract


A series of chalcones was synthesized to be (E)-1-(4-chlorophenyl)-3-p-tolyprop-2-en-1-on (1), (E)-1-(4-chlorophenyl)-3-(4-tolyprophenyl) prop-2-en-1-on (2), (E)-1-(3-bromophenyl)-3-p-tolylprop-2-en-1-on (3), and (E)-1-(3-bromophenyl)-3-(4-isopropyl phenyl) prop-2-en-1-on (4) using irradiate microwave method with reaction time from 3, 6, and 8 min at 800 °C and 700 W. The compounds were characterized using TLC, UV-Vis, FTIR, 1H-NMR, and evaluated MCF-7 cancer cell cytotoxic test with Presto BlueTM. All compounds produced were in the form of yellow crystals. The results showed that compounds 2, 3, and 4 were potentially a Como prevention agent and inhibit cell proliferation with IC50 values of 37.24, 422.22, and 22.41 ppm, respectively. While compound 1 had IC50 1,484.75 and no cytotoxic effect. Further tests should be carried out for compounds 2, 3, and 4 against normal cells to measure the compound's safety for normal cells.


Keywords


breast cancer; chalcones; MCF-7 cancer cell

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DOI: https://doi.org/10.22146/ijc.69991

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