Synthesis and Characterization of Ferrofluid-Chitosan-Au Nanoparticles as Brachytherapy Agent Candidate

Muflikhah Muflikhah(1*), Ahmad Marzuki Ramadhan(2), Maria Christina Prihatiningsih(3), Mujamilah Mujamilah(4), Aloma Karo Karo(5)

(1) Center for Science and Technology of Advanced Materials, National Nuclear Energy Agency of Indonesia, Kawasan Puspiptek Serpong, Banten 15314, Indonesia
(2) Polytechnic Institute of Nuclear Technology, National Nuclear Energy Agency of Indonesia, Jl. Babarsari POB 6101 Yk bb, Yogyakarta 55281, Indonesia
(3) Polytechnic Institute of Nuclear Technology, National Nuclear Energy Agency of Indonesia, Jl. Babarsari POB 6101 Yk bb, Yogyakarta 55281, Indonesia
(4) Center for Science and Technology of Advanced Materials, National Nuclear Energy Agency of Indonesia, Kawasan Puspiptek Serpong, Banten 15314, Indonesia
(5) Center for Science and Technology of Advanced Materials, National Nuclear Energy Agency of Indonesia, Kawasan Puspiptek Serpong, Banten 15314, Indonesia
(*) Corresponding Author


Brachytherapy is expected to be a solution to the side effect of other cancer therapy methods. This study aims to synthesize ferrofluids (FF)-Chitosan-Au (so-called cold synthesis) as the initial step before using 198Au that is expected to be a targeted and controllable brachytherapy agent. In this research, the preparation of FF-Chitosan was done by the co-precipitation method. Furthermore, FF-Chitosan-Au was produced via self-assembly by the adsorption method. The adsorption followed the Langmuir model with a maximum capacity of 30.24 mg Au/g FF-Chitosan. The X-Ray Diffractometion (XRD) of FF-Chitosan-Au confirms the existence of Au. Particle Size Analyzer (PSA) indicates FF-Chitosan-Au has an average size of 82.93 nm with a polydispersity index of 0.175. Morphological and distribution analysis of nanoparticles using Scanning Electron Microscope (SEM) shows that nanoparticles have a homogenous spherical shape. Vibrating Sample Magnetometer (VSM) measurement confirms the superparamagnetic properties of FF-Chitosan and FF-Chitosan-Au with a saturated magnetization of 80.48 and 74.52 emu/g, respectively. The overall results are associated with biomedical requirements, such as high saturation magnetization and good polydispersity. The synthesis can also be applied to produce FF-Chitosan-198Au that has great potential as a brachytherapy agent, which will reduce the nuclear waste and potential danger of radiation received by workers during synthesis.


ferrofluids; magnetic nanoparticle; adsorption; chitosan-gold, brachytherapy

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