Analysis of Dissolution of Salicylamide from Carrageenan Based Hard-Shell Capsules: A Study of the Drug-Matrix Interaction

https://doi.org/10.22146/ijc.55047

Muhammad Al Rizqi Dharma Fauzi(1), Esti Hendradi(2*), Pratiwi Pudjiastuti(3), Riyanto Teguh Widodo(4)

(1) Department of Chemistry, Faculty of Science, Universitas Airlangga, Campus C Mulyorejo, Surabaya 60115, Indonesia
(2) Department of Pharmaceutics, Faculty of Pharmacy, Universitas Airlangga, Campus C Mulyorejo, Surabaya 60115, Indonesia
(3) Department of Chemistry, Faculty of Science, Universitas Airlangga, Campus C Mulyorejo, Surabaya 60115, Indonesia
(4) Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Malaya, Kuala Lumpur 50603, Malaysia
(*) Corresponding Author

Abstract


In drug release kinetics, the drug-matrix interaction is one of the important mechanisms to be dictated. Unfortunately, there is still minimum information discussing the effect of interaction between a drug and its matrix to the release profile of the drug. Therefore, there is an urgent need to conduct research related to the study of drug-matrix interaction. This paper reports the preparation of a drug delivery system (DDS) in the form of hard-shell capsules containing salicylamide (SCA) and analyses its drug-matrix interaction via dissolution test at different pH media and various release kinetics models. The matrix of hard-shell capsules was prepared from κ-carrageenan (CRG), crosslinked with maltodextrin (MD), and plasticized by sorbitol (SOR). The chemical properties of SCA were compared with paracetamol (PCT) using computational analysis to help to depict its drug-matrix interaction. The statistical analyses showed that SCA and PCT at pH 1.2, 4.5, and 6.8 had all different release profiles. Based on the goodness of fit evaluation, the diffusion mechanism of SCA at pH 1.2 and 4.5 could be best described by the Peppas-Sahlin model while the zeroth-order model fitted the dissolution profile at pH 6.8. In summary, it was proven that a different drug-matrix interaction produced a different dissolution profile.

Keywords


polymer; carrageenan; drug release; release kinetic; dissolution

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References

[1] Zeng, L., An, L., and Wu, X., 2011, Modelling drug-carrier interaction in the drug release from nanocarriers, J. Drug Delivery, 2011, 370308.

[2] Press, A.T., Ramoji, A., von der Lühe, M., Rinkenauer, A.C., Hoff, J., Butans, M., Rössel, C., Pietsch, C., Neugebauer, U., Schacher, F.H., and Bauer, M., 2017, Cargo-carrier interactions significantly contribute to micellar conformation and biodistribution, NPG Asia Mater., 9, e444.

[3] Srinarong, P., Kouwen, S., Visser, M.R., Hinrichs, W.L.J., and Frijlink, H.W., 2010, Effect of drug-carrier interaction on the dissolution behavior of solid dispersion tablets, Pharm. Dev. Technol., 15 (5), 460–468.

[4] Unagolla, J.M., and Jayasuriya, A.C., 2018, Drug transport mechanisms, and in vitro release kinetics of vancomycin encapsulated chitosan-alginate polyelectrolyte microparticles as a controlled drug delivery system, Eur. J. Pharm. Sci., 114, 199–209.

[5] Hariyadi, D.M., Hendradi, E., and Sharon, N., 2019, Development of carrageenan polymer for encapsulation of ciprofloxacin HCL: In vitro characterization, Int. J. Drug Delivery Technol., 9 (1), 89–93.

[6] Fauzi, M.A.R.D., Pudjiastuti, P., Hendradi, E., Widodo, R.T., and Amin, M.C.I.M., 2020, Characterization, disintegration, and dissolution analyses of carrageenan based hard-shell capsules cross-linked with maltodextrin as a potential alternative drug delivery system, Int. J. Polym. Sci., 2020, 3565931.

[7] The United States Pharmacopoeial Convention, 2014, United States Pharmacopoeia (USP), Rockville, Maryland.

[8] Srividya, B., Sowmya, C., and Chappidi, S.R., 2014, Capsules and its technology: An overview, Int. J. Pharm. Drug Anal., 2 (9), 727–733

[9] Gullapalli, R.P., and Mazzitelli, C.L., 2017, Gelatin and non-gelatin capsule dosage forms, J. Pharm. Sci., 106 (6), 1453–1465.

[10] Ali, N.W., Zaazaa, H.E., and Abdelrahman, M.M., 2014, Novel spectrophotometric methods for determination of salicylamide and ascorbic acid in their binary mixture, J. Chem. Soc. Pak., 36 (6), 988–995.

[11] Peppas, N.A., and Sahlin, J.J., 1989, A simple equation for the description of solute release. III. Coupling of diffusion and relaxation, Int. J. Pharm., 57 (2), 169–172.

[12] Peppas, N.A., 1985, Analysis of Fickian and non-Fickian drug release from polymers, Pharm. Acta Helv., 60 (4), 110–111

[13] Uliniuc, A., Hamaide, T., Popa, M., and Băcăiţă, S., 2014, Modified starch-based hydrogels cross-linked with citric acid and their use as drug delivery systems for levofloxacin, Soft Mater., 11 (4), 483–493.

[14] Zhang, Y., Huo, M., Zhou, J., Zou, A., Li, W., Yao, C., and Xie, S., 2010, DDSolver: An add-in program for modeling and comparison of drug dissolution profiles, AAPS J., 12 (3), 263–271.

[15] Kulpreechanan, N. and Sorasitthiyanukarn, F.N., 2020, Evaluation of in vitro release kinetics of Capsaicin-loaded chitosan nanoparticles using DDSolver, Int. J. Res. Pharm. Sci., 11 (3), 4555–4559.

[16] Bernal, V., Erto, A., Giraldo, L., and Piraján, J.C.M., 2017, Effect of solution pH on the adsorption of paracetamol on chemistry modified activated carbons, Molecules, 22 (7), 1032.

[17] Lemke, T.L., Williams, D.A., Roche, V.F., and Zito, S.W., 2017, Foye’s Principles of Medicinal Chemistry, 7th Ed., Lippincott Williams & Wilkins, Philadelphia, USA, 965–970.

[18] Hermann, J., DiStasio, R.A., and Tkachenko, A., 2017, First-principles models for van der Waals interactions in molecules and materials: Concepts, theory, and applications, Chem. Rev., 117 (6), 4714–4758.

[19] Fu, T., and Kao, W.J., 2010, Drug release kinetics and transport mechanisms of non-degradable and degradable polymeric delivery systems, Expert Opin. Drug Delivery, 7 (4), 429–444.

[20] Zhao, Y.N., Xu, X., Wen, N., Song, R., Meng, Q., Guan, Y., Cheng, S., Cao, D., Dong, Y., Qie, J., Liu, K., and Zhang, K., 2017, A drug carrier for sustained zero order release of peptide therapeutics, Sci. Rep., 7, 5524.

[21] Varelas, C.G., Dixon, D.G., and Steiner, C.A., 1995, Zero-order release from biphasic polymer hydrogels, J. Controlled Release, 34 (3), 185–192.

[22] Paul, D.R., 2011, Elaborations on the Higuchi model for drug delivery, Int. J. Pharm., 418 (1), 13–17.

[23] Paarakh, M.P., Jose, P.A., Setty, C.M., and Christoper, G.V.P., 2018, Release kinetics – Concepts and applications, IJPRT., 8, 12–20.

[24] Diksha, S., Dhruv, D., Prasad D.N., and Mansi, H., 2019, Sustained release drug delivery system with the role of natural polymers: A review, J. Drug Delivery Ther., 9 (3-s), 913–923.



DOI: https://doi.org/10.22146/ijc.55047

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