One-Pot-Multicomponent Synthesis of 2,6-Diamino-4-arylpyridine-3,5-dicarbonitrile Derivatives Using Nanomagnetic Fe3O4@SiO2@ZnCl2

Behrooz Maleki(1*), Hadi Natheghi(2), Vahid Sokhanvaran(3), Samaneh Sedigh Ashrafi(4)

(1) Department of Chemistry, Faculty of Sciences, Hakim Sabzevari University, Sabzevar 96179-76487, Iran
(2) Department of Chemistry, Faculty of Sciences, Hakim Sabzevari University, Sabzevar 96179-76487, Iran
(3) Faculty of Basic Sciences, University of Neyshabur, Neyshabur, Iran
(4) Department of Chemistry, Faculty of Sciences, Hakim Sabzevari University, Sabzevar 96179-76487, Iran
(*) Corresponding Author


Nanomagnetic Fe3O4@SiO2@ZnCl2 was used as a simple, cost-effective, and reusable heterogeneous catalyst for the synthesis of 2,6-diamino-4-arylpyridine-3,5-dicarbonitriles by a one-pot-three-component condensation reaction of malononitrile, ammonium acetate, and aldehydes under solvent-free conditions at 110 °C. Simple and mild reaction conditions, facile preparation of the catalyst, the use of a cheap catalyst and easy workup and isolation are notable features of this method.


2,6-diamino-4-arylpyridine-3,5-dicarbonitriles; nano magnetic Fe3O4@SiO2@ZnCl2; green chemistry; multi-component reaction

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