Incorporation of Poly(Vinyl Alcohol) for The Improved Properties of Hydrothermal Derived Calcium Phosphate Cements

Nurul Nabilah Razali; Iis Sopyan

doi:10.22146/ijc.29746

Incorporation of Poly(Vinyl Alcohol) for The Improved Properties of Hydrothermal Derived Calcium Phosphate Cements

https://doi.org/10.22146/ijc.29746

Nurul Nabilah Razali⁽¹⁾, Iis Sopyan^(2*)

(1) Department of Manufacturing and Materials Engineering, Faculty of Engineering, International Islamic University Malaysia
(2) Department of Manufacturing and Materials Engineering, Faculty of Engineering, International Islamic University Malaysia
(*) Corresponding Author

Abstract

Calcium phosphate cement (CPC) has been synthesized via a straightforward hydrothermal route. Calcium oxide and ammonium dihydrogen phosphate were used as calcium and phosphate precursors. The precursors were refluxed in distilled water at 90–100 °C and dried overnight until the calcium phosphate powder was formed. CPC was then produced by mixing the powder and distilled water at the powder-to-liquid (P/L) ratio of 1.5. Poly(vinyl alcohol) (PVA) of 1 to 7% (w/w) was added and its effect on physical properties was investigated. It was proved that PVA addition up to 7% (w/w) has shortened the setting time but decreased the injectability. The PVA free CPC has the initial and final setting times of 71 and 187 min, respectively and the injectability of 99.92%. The compressive strength also increased with the amount of PVA added in CPC. In addition, soaking CPC in Ringer's solution for 7, 14 and 21 days also gave remarkable effects on cohesion, microstructure and mechanical properties of the cement.

Keywords

calcium phosphate cement; hydrothermal method; poly(vinyl alcohol); setting time; injectability

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References

[1] Banwart, J.C., Asher, M.A., and Hassanein, R.S., 1995, Iliac crest bone graft harvest donor site morbidity: A statistical evaluation, Spine, 20 (9), 1055–1060.

[2] Sarkar, M.R., Wachter, N., Patka, P., and Kinzl, L., 2001, First histological observations on the incorporation of a novel calcium phosphate bone substitute material in human cancellous bone, J. Biomed. Mater. Res., 58 (3), 329–334.

[3] Bohner, M., Merkle, H.P., Landuyt, P.V., Trophardy, G., and Lemaitre, J., 2000, Effect of several additives and their admixtures on the physico-chemical properties of a calcium phosphate cement, J. Mater. Sci. - Mater. Med., 11 (2), 111–116.

[4] Wang, X., Ma, J., Wang, Y., and He, B., 2001, Structural characterization of phosphorylated chitosan and their applications as elective additives of calcium phosphate cements, Biomaterials, 22 (16), 2247–2255.

[5] Zhang, C., Yang, J., Quan, Z., Yang, P., Li, C., Hou, Z., and Lin, J., 2009, Hydroxyapatite nano- and microcrystals with multiform morphologies: Controllable synthesis and luminescence properties, Cryst. Growth Des., 9 (6), 2725–2733.

[6] Bezzi, G., Celotti, G., Landi, E., La Toreetta, T.M.G., Sopyan, I., and Tampieri, A., 2003, A novel sol-gel technique for hydroxyapatite preparation, Mater. Chem. Phys., 78 (3), 816–824.

[7] Monma, H., and Kamiya, T., 1987, Preparation of hydroxyapatite by the hydrolysis of brushite, J. Mater. Sci., 22 (12), 4247–4250.

[8] Pramanik, S., Agarwal, A.K., Rai, K.N., and Garg, A., 2007, Development of high strength hydroxyapatite by solid-state sintering process, Ceram. Int., 33 (3), 419–426.

[9] Liu, J., Ye, X., Wang, H., Zhu, M., Wang, B., and Yan, H., 2003, The Influence of pH and temperature on the morphology of hydroxyapatite synthesized by hydrothermal method, Ceram. Int., 29 (6), 629–633.

[10] Zhang, J., Liu, W., Gauthier, O., Sourice, S., Pilet, P., Rethore, G., Khairoun, K., Bouler, J.M., Tancret, F., and Wiess, P., 2014, Calcium phosphate cements for bone substitution: chemistry, handling and mechanical properties, Acta Biomater., 10 (3), 1035–1049.

[11] Li, L., Peng, X., Qin, Y., Wang, R., Tang, J., Cui, X., Wang, T., Liu, W., Oan, H., and Li, B., 2017, Acceleration of bone regeneration by activating wnt/β-catenin signalling pathway via lithium released from lithium chloride/calcium phosphate cement in osteoporosis, Sci. Rep., 7, 45204, 1–12.

[12] Lopez-Heredia, M.A., Sariibrahimoglu, K., Yang, W., Bohner, M., Yamashita, D., Kunstar, A., van Apeldoorn, A.A., Bronkhorst, E.M., Félix Lanao, R.P., Leeuwenburgh, S.C., Itatani, K., Yang, F., Salmon, P., Wolke, J.G., and Jansen, J.A., 2012, Influence of the pore generator on the evolution of the mechanical properties and the porosity and interconnectivity of a calcium phosphate cement, Acta Biomater., 8 (1), 404–414.

[13] Sariibrahimoglu, K., Leeuwenburgh, S.C.G., Wolke, J.G.C., Yubao, L., and Jansen, J.A., 2012, Effect of calcium carbonate on hardening, physicochemical properties, and in vitro degradation of injectable calcium phosphate cements, J. Biomed. Mater. Res. PartA, 100(3), 712–719.

[14] Perez, R.A., Kim, H.W., and Ginebra, M.P., 2012, Polymeric additives to enhance the functional properties of calcium phosphate cements, J. Tissue Eng., 3 (1), 1–21.

[15] Engstrand, J., Persson, C., and Engqvist, H., 2013, Influence of polymer addition on the mechanical properties of a premixed calcium phosphate cement, Biomatter, 3 (4), e27249, 1–6.

[16] Renno, A.C., Nejadnik, M.R., van de Watering, F.C., Crovace, M.C., Zanotto, E.D., Hoefnagels, J.P., Wolke, J.G., Jansen, J.A., and van den Beucken, J.J., 2013, Incorporation of bioactive glass in calcium phosphate cement: material characterization and in vitro degradation, J. Biomed. Mater. Res. Part A, 101 (8), 2365–2373.

[17] Khashaba, R.M., Moussa, M.M., Mettenburg, D.J., Rueggeberg, F.A., Chutkan, N.B., and Borke, J.L., 2010, Polymeric-calcium phosphate cement composites-materials properties: in vitro and in Vivo investigations, Int. J. Biomater., 2010, 691452, 1–14.

[18] Rampe, M.J., Setiaji, B., Trisunaryanti, W., and Triyono, 2011, Fabrication and characterization of carbon composite from coconut shell carbon, Indones. J. Chem., 11 (2), 124–130.

[19] Wahyuningsih, K., Iriani, E.S., and Fahma, F., 2016, Utilization of cellulose from pineapple leaf fibers as nanofiller in polyvinyl alcohol-based film, Indones. J. Chem., 16 (2), 181–189.

[20] Erizal and Rahayu, C., 2009, Thermo-responsive hydrogel of polyvinyl alcohol (PVA)-co-N-isopropyl acrylamide (NIPAAM) prepared by γ radiation as a matrix pumping/on-off system, Indones. J. Chem., 9 (1), 19–27.

[21] Perkasa, D.P., Erizal, and Abbas, B., 2013, Polymeric biomaterials film based on poly(vinyl alcohol) and fish scale collagen by repetitive freeze-thaw cycles followed by gamma irradiation, Indones. J. Chem., 13 (3), 221–228.

[22] Lusiana, R.A., Siswanta, D., Mudasir, and Hayashita, T., 2013. The influence of PVA.cl.citric acid/chitosan membrane hydrophilicity on the transport of creatinine and urea, Indones. J. Chem., 13 (3), 262–270.

[23] Li, C., Gao, L., Chen, F., and Liu, C., 2015, Fabrication of mesoporous calcium silicate/calcium phosphate cement scaffolds with high mechanical strength by freeform fabrication system with micro-droplet jetting, J. Mater. Sci., 50 (22), 7182–7191.

[24] Rajzer, I., Castano, O., Engel, E., and Planell, J.A., 2010, Injectable and fast resorbable calcium phosphate cement for body-setting bone grafts, J. Mater. Sci. - Mater. Med., 21 (7), 2049–2056.

[25] Alqap, A.S.F., and Sopyan, I., 2009, Low temperature hydrothermal synthesis of calcium phosphate ceramics: effect of excess Ca precursor on phase behavior, Indian. J. Chem., Sect. A, 48A (11), 1492–1500.

[26] Mohammadi, M., Herasaki, S., and Ardakani, M.H., 2012, Effect of adding nano-silicon carbide on mechanical properties and hydroxyapatite formation in calcium phosphate cements, Proceedings of ICBME 2012, 20–21 December, Tehran, Iran.

[27] Müller, L., and Müller, F.A., 2006, Preparation of SBF with different HCO₃^- content and its influence on the composition of biomimetic apatites, Acta Biomater., 2(2), 181-189.

DOI: https://doi.org/10.22146/ijc.29746