One-Pot Eco-Safe Saccharin-Catalyzed Procedure for Expedient and Convenient Synthesis of Dihydropyrano[2,3-c]pyrazole, Tetrahydrobenzo[b]pyran and Pyrano[2,3-d]pyrimidinone Scaffolds as a Green and Versatile Catalyst

https://doi.org/10.22146/ijc.28450

Farzaneh Mohamadpour(1), Mojtaba Lashkari(2*), Nourallah Hazeri(3)

(1) Department of Chemistry, Faculty of Science, University of Sistan and Baluchestan, P.O. Box 98135-674 Zahedan, Iran
(2) Faculty of Science, Velayat University, Iranshahr, Iran
(3) Department of Chemistry, Faculty of Science, University of Sistan and Baluchestan, P.O. Box 98135-674 Zahedan, Iran
(*) Corresponding Author

Abstract


A green and facile saccharin-catalyzed procedure is developed for the one-pot convenient synthesis of dihydropyrano[2,3-c]pyrazole, tetrahydrobenzo[b]pyran and pyrano[2,3-d]pyrimidinone scaffolds via multi-component tandem Knoevenagel cyclocondensation reaction. This procedure has the chief advantages of green, inexpensive and readily available catalyst, high atom-economy, high to quantitative yields and the reaction procedure is mild and involves facile workup procedure to obtain the desired products in short reaction times.


Keywords


green procedures; saccharin; dihydropyrano[2,3-c]pyrazoles; tetrahydrobenzo[b]pyrans; pyrano[2,3-d]pyrimidinones

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References

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DOI: https://doi.org/10.22146/ijc.28450

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