Isolation and Antioxidant and Antibacterial Activity of Flavonoid from Ficus variegate Blume

https://doi.org/10.22146/ijc.23947

Rolan Rusli(1*), Bela Apriliana Ningsih(2), Agung Rahmadani(3), Lizma Febrina(4), Vina Maulidya(5), Jaka Fadraersada(6)

(1) Faculty of Pharmacy, University of Mulawarman, Samarinda, East Kalimantan
(2) Faculty of Pharmacy, University of Mulawarman, Samarinda, East Kalimantan
(3) Faculty of Pharmacy, University of Mulawarman, Samarinda, East Kalimantan
(4) Faculty of Pharmacy, University of Mulawarman, Samarinda, East Kalimantan
(5) Faculty of Pharmacy, University of Mulawarman, Samarinda, East Kalimantan
(6) Faculty of Pharmacy, University of Mulawarman, Samarinda, East Kalimantan
(*) Corresponding Author

Abstract


Ficus variegata Blume is specific plant of east Kalimantan. Flavonoid compound of Ficus variegata Blume was isolated by vacuum liquid and column chromatography, with previously extracted by maceration method using n-hexane and methanol, and fractination using ethyl acetate solvent. Eluent used in isolation were n-hexane:ethyl acetate (8:2). The results of elucidation structure by using spectroscopy methods (GC-MS, NMR, and FTIR) was obtained 5-Hidroxy-2-(4-methoxy-phenyl)-8,8-dymethyl-8H-pyrano[2,3-f] chromen-4-one. This compound has an antibacterial and antioxidant activities.

Keywords


Ficus variegata Blume; flavonoid; antibacterial activities; antioxidant activities

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References

[1] Weiblen, G.D., 2000, Phylogenetic relationships of functionally dioecious FICUS (Moraceae) based on ribosomal DNA sequences and morphology, Am. J. Bot., 87 (9), 1342–1357.

[2] Berg, C.C., 1989, Classification and distribution of Ficus, Experientia, 45 (7), 605–611.

[3] Harrison, R.D., 2005, Figs and the diversity of tropical rainforests, BioScience, 55 (12), 1053–1064.

[4] Sirisha, N., Sreenivasulu, M., Sangeeta, K., and Chetty, C.M., 2010, Antioxidant properties of Ficus species - A review, Int. J. PharmTech Res., 2 (4), 2174–2182.

[5] Haryjanto, L., and Prastyono, 2014, Pendugaan parameter genetik semai nyawai (Ficus variegata Blume) asal pulau Lombok, JPK Wallacea, 3 (1), 37–45.

[6] Ningsih, B.A., Rahmadani, A., Fadraersada, J., and Rusli, R., 2016, Aktivitas antibakteri dan antioksidan isolat fraksi etil asetat buah libo (Ficus variegata Blume), Prosiding Seminar Nasional Tumbuhan Obat Indonesia (TOI) Ke-50, 20-21 April, 2016, Faculty of Pharmacy, University of Mulawarman, Samarinda, Indonesia.

[7] Rusli, R., Hardina, M.P., Muflihah, F., and Rahmadani, A., 2015, Profil kromatografi senyawa aktif antioksidan dan antibakteri fraksi n-heksana daun Libo (Ficus variegata Blume), J. Trop. Pharm. Chem., 3 (2), 124–130.

[8] Saleh, R.A., Rahmadani, A., Febrina, L., and Rusli, R., 2016, Aktivitas antibakteri kulit batang Libo (Ficus variegate Blume), Prosiding Seminar Nasional Tumbuhan Obat Indonesia (TOI) Ke-50, 20-21 April, 2016, Faculty of Pharmacy, University of Mulawarman, Samarinda, Indonesia.

[9] Rusli, R., Rosniar, Haeruddin, and Nurlansi, 2011, Identifikasi gugus fungsi minyak buah nipa (Nypa fructicans) Kaliwanggu Teluk Kendari Sulawesi Tenggara, J. Trop. Pharm. Chem., 1 (2), 143–149.

[10] Cushnie, T.T.P., and Lamb, A.J., 2005, Antimicrobial activity of flavonoids, Int. J. Antimicrob. Agents, 26, 343–356.

[11] Jusmiati, J., Rusli, R., and Rijai, L., 2015, Aktivitas antioksidan kulit buah kakao masak dan kulit buah kakao muda, J. Sains Kes., 1 (1), 34–39.

[12] Procházková, D., Boušová, I., and Wilhelmová, N., 2011, Antioxidant and prooxidant properties of flavonoids, Fitoterapia, 82, 513–523.



DOI: https://doi.org/10.22146/ijc.23947

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