Cinnamic Acid Derivatives as α-Glucosidase Inhibitor Agents

Teni Ernawati; Maksum Radji; Muhammad Hanafi; Abdul Mun’im; Arry Yanuar

doi:10.22146/ijc.23572

Cinnamic Acid Derivatives as α-Glucosidase Inhibitor Agents

https://doi.org/10.22146/ijc.23572

Teni Ernawati^(1*), Maksum Radji⁽²⁾, Muhammad Hanafi⁽³⁾, Abdul Mun’im⁽⁴⁾, Arry Yanuar⁽⁵⁾

(1) Research Center for Chemistry – Indonesian Institute of Sciences (LIPI), Kawasan Puspiptek, Serpong Tangerang Selatan, Banten 15314
(2) Faculty of Pharmacy, Universitas Indonesia, Depok 16242
(3) Research Center for Chemistry – Indonesian Institute of Sciences (LIPI), Kawasan Puspiptek, Serpong Tangerang Selatan, Banten 15314
(4) Faculty of Pharmacy, Universitas Indonesia, Depok 16242
(5) Faculty of Pharmacy, Universitas Indonesia, Depok 16242
(*) Corresponding Author

Abstract

This paper reviews biological activity of some cinnamic acid derivative compounds which are isolated from natural materials and synthesized from the chemical compounds as an agent of α-glucosidase inhibitors for the antidiabetic drug. Aegeline, anhydroaegeline and aeglinoside B are natural products isolated compounds that have potential as an α-glucosidase inhibitor. Meanwhile, α-glucosidase inhibitor class of derivatives of cinnamic acid synthesized compounds are p-methoxy cinnamic acid and p-methoxyethyl cinnamate. Chemically, cinnamic acid has three main functional groups: first is the substitution of the phenyl group, second is the additive reaction into the α-β unsaturated, and third is the chemical reaction with carboxylic acid functional groups. The synthesis and modification of the structure of cinnamic acid are very influential in inhibitory activity against α-glucosidase.

Keywords

cinnamic acid derivative; α-glucosidase inhibitor; antidiabetic; synthesis; natural products

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DOI: https://doi.org/10.22146/ijc.23572