A New Polyketide from the Endophytic Fungus Penicillium chermesinum


Cici Darsih(1*), Vilailak Prachyawarakorn(2), Chulabhorn Mahidol(3), Somsak Ruchirawat(4), Prasat Kittakoop(5)

(1) Research Unit for Natural Products Technology, Indonesian Institute of Sciences, Gading, Playen, Gunungkidul, Yogyakarta 55581, Indonesia
(2) Chulabhorn Research Institute, Kamphaeng Phet 6 Road, Laksi, Bangkok 10210, Thailand
(3) Chulabhorn Research Institute, Kamphaeng Phet 6 Road, Laksi, Bangkok 10210, Thailand
(4) Chulabhorn Graduate Institute, Chemical Biology Program, Kamphaeng Phet 6 Road, Laksi, Bangkok 10210, Thailand
(5) Chulabhorn Graduate Institute, Chemical Biology Program, Kamphaeng Phet 6 Road, Laksi, Bangkok 10210, Thailand
(*) Corresponding Author


A new polyketide derivative, 2-chloro-3,4,7-trihydroxy-9-methoxy-1-methyl-6H-benzo[c]chromen-6-one (1), was isolated from the endophytic fungus Penicillium chermesinum. The structure was established on the basis of UV, IR, HR-ESI MS, and 1D and 2D NMR experiments. The cytotoxicity against four cancer cell lines (HuCCA-1, HepG2, A-549, and MOLT-3) of compound 1 are 14.94-115.71 µM.


Penicillium chermesinum; natural products; polyketide; endophytic fungi; cytotoxicity

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DOI: https://doi.org/10.22146/ijc.22273

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