A New Polyketide from the Endophytic Fungus  Penicillium chermesinum

Cici Darsih; Vilailak Prachyawarakorn; Chulabhorn Mahidol; Somsak Ruchirawat; Prasat Kittakoop

doi:10.22146/ijc.22273

A New Polyketide from the Endophytic Fungus Penicillium chermesinum

https://doi.org/10.22146/ijc.22273

Cici Darsih^(1*), Vilailak Prachyawarakorn⁽²⁾, Chulabhorn Mahidol⁽³⁾, Somsak Ruchirawat⁽⁴⁾, Prasat Kittakoop⁽⁵⁾

(1) Research Unit for Natural Products Technology, Indonesian Institute of Sciences, Gading, Playen, Gunungkidul, Yogyakarta 55581, Indonesia
(2) Chulabhorn Research Institute, Kamphaeng Phet 6 Road, Laksi, Bangkok 10210, Thailand
(3) Chulabhorn Research Institute, Kamphaeng Phet 6 Road, Laksi, Bangkok 10210, Thailand
(4) Chulabhorn Graduate Institute, Chemical Biology Program, Kamphaeng Phet 6 Road, Laksi, Bangkok 10210, Thailand
(5) Chulabhorn Graduate Institute, Chemical Biology Program, Kamphaeng Phet 6 Road, Laksi, Bangkok 10210, Thailand
(*) Corresponding Author

Abstract

A new polyketide derivative, 2-chloro-3,4,7-trihydroxy-9-methoxy-1-methyl-6H-benzo[c]chromen-6-one (1), was isolated from the endophytic fungus Penicillium chermesinum. The structure was established on the basis of UV, IR, HR-ESI MS, and 1D and 2D NMR experiments. The cytotoxicity against four cancer cell lines (HuCCA-1, HepG2, A-549, and MOLT-3) of compound 1 are 14.94-115.71 µM.

Keywords

Penicillium chermesinum; natural products; polyketide; endophytic fungi; cytotoxicity

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DOI: https://doi.org/10.22146/ijc.22273