ISOLATION AND STRUCTURE DETERMINATION OF BISDEMTHYLAAPTAMINE FROM BUNAKEN MARINE PARK SPONGE Aaptos, sp.

https://doi.org/10.22146/ijc.21881

Wilson AR Rombang(1*), Rymond J Rumampuk(2), Ponis Tarigan(3), Anthony J Herlt(4), Lewis N Mander(5)

(1) Jurusan Kimia, Universitas Negeri Manado, Tondano-Minahasa, Sulawesi Utara 95618
(2) Pusat Penelitian Kimia, Lembaga Ilmu Pengetahuan Indonesia, Jalan Cisitu-Sangkuriang Gedung 50, Bandung 40135
(3) Jurusan Kimia, Universitas Padjadjaran, Jalan Singaperbangsa no.2 Bandung 40133
(4) Research School of Chemistry, Australian National University, Canberra ACT 0200
(5) Research School of Chemistry, Australian National University, Canberra ACT 0200
(*) Corresponding Author

Abstract


Bisdemethylaaptamine, an alkaloid naphtyridine with molecular weight 200 and formulae molecule C11H8N2O2 has been isolated from Bunaken Marine Park sponge Aaptos sp. Isolation was done by using several stages of column chromatography and high performance liquid chromatography. Molecular weight of this naphtyridine alkaloid was determined by electron ionization (EI) and electrospray ionization (ESI) mass spectroscopies and its structure assigned to be 8,9-dihydroxy-1H-benzo[d,e][1,6]naphtyridine by proton and carbon nuclear magnetic resonances (1H and 13C-NMR).


Keywords


Sponge; Aaptos sp.; naphtyridine alkaloid; bisdemethylaaptamin

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References

[1] Rombang, W. A. R., Rumampuk, R. J.; Soemitro, S., Tarigan, P., 2001, Prosiding Seminar Nasional Kimia, Jurusan Kimia, Universitas Negeri Yogyakarta, 382-387.

[2] Rahmaniar, R.S., 2001, Proceedings of the International Seminar on Natural Products Chemistry and Utilization Resources, Universitas Indonesia – UNESCO, 86-88.

[3] Rombang, W. A. R., Rumampuk, R. J., Soemitro, S., Tarigan, P., 2001, Prosiding Seminar Nasional Kimia. Jurusan Kimia, Universitas Sebelas Maret, Surakarta.

[4] Rudi, A., Kashman, Y., 1993, Tetrahedron Lett., 34, 4683-4684.

[5] Granato, A.C., Berlinck, R.G.S., Magalhaes, A., Schefer, A.B., Ferreira, A.G., de Sanctis, B., de Freitas, Y.C., Migotto, E.H.A.E., 2000, Quimica Nova, 23, 594-599.

[6] Ohizumi, Y.; Kajiwara, A.; Nakamura, H.; Kobayashi, J., 1984, J. Pharm. Pharmacol. 36, 785-786.

[7] Shen, Y.C., Lin, T.T., Sheu, J.H., Duh, C.Y., 1999, J. Nat. Prod., 62, 1264-1267.

[8] Coutinho, A.F., Chanas, B., e Souza, T.M.L., Frugrulhetti, I.C.P.P., Epifanio, R. de A., 2002, Heterocyles., 57, 1265-1272.

[9] Calcul, L., Longeon, A., Al Maurabit, A., Guyot, M., Bourguet-Kondracki, M.L., 2003, Tetrahedron. 59, 6539-6544.

[10] Takamatsu, S., Hodges, T., W., Rajbhandari, I., Gerwick, W. H., Hamann, M.T., Nagle, D.G., 2003, J. Nat. Prod., 66, 605-608.

[11] Rombang, W. A. R., Rumampuk, R. J., Safitri, R., Tarigan, P., 2003, Presentasi pada International Symposium on Biomedicines. Bogor Agryculture University, Bogor.

[12] von Nussbaum, F., Schumann, S., Steglich, W. 2001 Tetrahedron. 57, 2331-2335.

[13] Nakamura, H., Kobayashi, J., Ohizumi, Y., 1982, Tetrahedron Lett., 23, 5555-5558.



DOI: https://doi.org/10.22146/ijc.21881

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