Tutik Dwi Wahyuningsih(1*)

(1) Chemistry Department, Faculty of Mathematics and Natural Sciences, Universitas Gadjah Mada, Yogyakarta
(*) Corresponding Author


3-(4'-Bromophenyl)-4,6-dimethoxy-2-methylindole has been synthesized from 4,6-dimethoxyaniline via the modified Bischler method. Reaction of 4,6-dimethoxyaniline with 2,4-dibromopropiophenone gave an aniline ketone in 85%, and then it was protected to give the amido ketone as a white solid. Cyclization of amido ketone was performed by trifluoroacetic acid and subsequent deprotection with potassium hydroxide in methanol afforded a white solid of 3-(4'-bromophenyl)-4,6-dimethoxy-2-methylindole in 86%.


4,6-dimethoxyaniline; 2-methylindole; Bischler method

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Indonesian Journal of Chemistry (ISSN 1411-9420 / 2460-1578) - Chemistry Department, Universitas Gadjah Mada, Indonesia.

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