SYNTHESIS OF UK-3A ANALOGUE AND ASSAY ON P 388 MURINE LEUKEMIA CELLS

https://doi.org/10.22146/ijc.21701

Y Anita(1*), M Hanafi(2), AMJ Putra(3), S Arifin(4), Y Usuki(5), H Iio(6)

(1) LIPI-Research Centre for Chemistry, Kawasan Puspiptek –Tangerang 15314
(2) LIPI-Research Centre for Chemistry, Kawasan Puspiptek –Tangerang 15314
(3) LIPI-Research Centre for Chemistry, Kawasan Puspiptek –Tangerang 15314
(4) Department of Chemistry, University of General Soedirman, Purwokerto, Indonesia
(5) Osaka City University, Department of Material Science, Osaka-Japan
(6) Osaka City University, Department of Material Science, Osaka-Japan
(*) Corresponding Author

Abstract


UK-3A is secondary metabolite of Streptomyces sp.517-02 which has IC50 38 µg/mL against P388 Murine Leukemia cells. An analogue of UK-3A was synthesized from L-methyl serine as the starting material by amidation and esterification. An analogue UK-3A was analyzed and identified by TLC, FT-IR, LC-MS and NMR spectrometer. It was found to have IC50 15.4µg/mL against the same Leukemia cells. The overall yield was 87.10%.

 

Keywords: UK-3A, Streptomyces sp. 517-02, Anticancer, P388 Murine Leukeumia cell


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DOI: https://doi.org/10.22146/ijc.21701

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Indonesian Journal of Chemisty (ISSN 1411-9420 / 2460-1578) - Chemistry Department, Universitas Gadjah Mada, Indonesia.

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