THE EFFECT OF HYDROGEL DRESSING COPOLYMER POLI(VINYLPIRROLIDONE) (PVP) - k- CARRAGEENAN PREPARED BY RADIATION AND HEALING TIMES ON THE RADIUS REDUCTIONS BURN INJURIED OF WISTAR WHITE RAT

https://doi.org/10.22146/ijc.21633

Erizal Erizal(1*)

(1) Centre for the Application Technology of Isotopes and Radiation, National Nuclear Energy Agency, Jl. Cinere Ps. Jumat PO BOX 7002, JKSKL 12070
(*) Corresponding Author

Abstract


The pre-clinical study of poly (vinyl pirrolidone) (PVP)-k- carrageenan hydrogel has been carried out. The aim of this study is to investigate the effect of hydrogel for healing burn injuried in the rats. The hydrogels were prepared by g-irradiation of aqueous solutions of 15 wt.-% PVP and 2 wt.-% k- carrageenan at a sterilization dose of 25 kGy. The physico-chemical properties of hydrogels were investigated. The results showed that the hydrogels suitable as candidate for wound dressing with gel fraction of 90 ± 5 (%), the water absorption was 4500 ± 55 (w/w), the water content was 83 ± 2 (%), tensile strength was 1,5 ± 0,1 kg/cm2 and adhesiveness was 0. The effect of the hydrogel as wound dressing was evaluated by attaching to a burn of the back skin of rats as a function of time observation. Advantages of the hydrogel were slightly faster rate of reducing radius diameter of injured burn skin, easy removal without damage to renewed skin.


Keywords


hydrogel; irradiation; copolymer; PVP; k carrageenan; diameter

Full Text:

Full Text Pdf


References

[1]   Erizal, 2006,  Prosiding Simposium Nasional Polimer VI , 111-115.

[2]   Erizal, 2006, Jurnal Materi Indonesia, 124-128.

[3]   Erizal, Hasan,R., Silvia,S., and Rahayu,C.,  1997, Risalah Pertemuan Ilmiah Penelitian dan Pengembangan Aplikasi Isotop dan Radiasi  121-128.

[4]   Kaetsu, I., 1979, Radiat.Phys. Chem. 14,  595-602..

[5]   Kumakura, M., and Kaetsu, I., 1984, Acta Chimica Hungaria, 116, 4,  345-351.

[6]   Kumakura, M., and Kaetsu, I., 1984, Acta Chimica Hungaria, 116, 4,  345-351.

[7]   Rosiak, J.M., Ulanski, P., Pajewksi, L.A.,and Yoshii, F., 1995, Radiat.Phys.Chem, 46, 2, 161.

[8]   Kaetsu, I., 1995,  Radiat.Phys. 40,  1025.

[9]   Zhao, L., Mitomo, H., Nagasawa, N., Yoshii, F., and Kume, T., 2003,  Carbohydrate Polymers, 51,  169-175.

[10] Zhao, X., Kato, K., Fukumoto, Y., and Nakamae, K., 2001, Int. J. Adhesion and Adhesives, 21,  227-232.

[11] Tamada, M., Seko, N., and Yoshii, F., 2004, Radiat. Phys.Chem. 71 221-225.

[12] Maolin, Z., Hongfei, H., and Yoshii, F., 2000, Radiat.Phys. Chem., 57, 459-464.

[13] Maolin, Z., Yoshii, F., Kume, T., and Hashim, K., 2002, Carbohydrate Polymer, 50,  295-303.

[14] Yoshii, F., Zhusan, Y., Isobe, K., Shinozaki, K., and Makuuchi, K.,1999,Radiat. Phys.Chem,55, 133-137.

[15] Anonim, 1992,  Specialty Plastic for Biomedical and Pharmaceutical Applications, 319-325.

[16] MichaeL, P.T., and Stephen, E.H., 1998, An Introduction to Polysaccharide Biotechnology, Taylor and Francis, 138-139

[17] Wade, A., and Weller, P.J., 1994,  Handbook of Pharmaceutical Exipient ,  2 nd  Edition ,London, The Pharmaceutical Press,  392.

[18] Cynthia, A.W., 2005, Dermal.Nurs. 17, 3, 204-206.

[19] Syamsulhidajat, R., and  Wim, D.J., 1997,  Buku –Ajar  Ilmu Bedah , Penerbit buku kedokteran EGC, 72-101.

[20] Morton, J.J,P and Malone, M.H.,.1972, Arch Int Pharm, 196,117-126.

[21] Tarusaraya, P., Hilmy, N.,  and  Basril, A., 2001, Proc. 7 th Int.Conf.Tissue Banks,

[22] Syafruddin, S., 2004, Statistik Terapan, Gramedia Widiasarana, Jakarta ,129-169.

[23] Zainuddin, Justin, J.C. and David, J.T.H., 2002, J.Biomaterials Science,13, 9,1007-1020.

[24] Swasono, R.T., Erizal, and Hendriyanto, 2007, Jurnal  Sains dan Teknologi Nuklir Indonesia, VIII, 1, 1-16.

[25] Nikitina, T.S., 1963,  Effect Ionizing Radiation on High Polymers, Gordon and Breach, New York,   1-11.

[26] Lorna, R., Fumio, Y., Alumanda, D.R., and Tamikazu, K., 2000, Die Angewandte Makromolekulare Chemie, 273, 63-68.. 

[27] AAMI. Technical Information Report (TIR-27), 2001, Sterilization of Health Care Products –Radiation Sterilization Substance of 25 kGy as Sterlization Dose-V Dmax, MC Lean, Virginia, USA.

[28] Viincent, F., 2007, Wound Healing,. :http://www.aad.org./professionals/residents/medStud cere Cusr/bc wound healing.hmt, 20 Desember 2007.

[29] Thomas, R., 2007, Wound Healing,  http://emedicene.com/ent/TOPIC13 HTM, 20 Desember 2007.



DOI: https://doi.org/10.22146/ijc.21633

Article Metrics

Abstract views : 374 | views : 2439


Copyright (c) 2010 Indonesian Journal of Chemistry

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

 


Indonesian Journal of Chemistry (ISSN 1411-9420 / 2460-1578) - Chemistry Department, Universitas Gadjah Mada, Indonesia.

Web
Analytics View The Statistics of Indones. J. Chem.