DETERMINATION AND VALIDATION OF MEBHYDROLINE NAPADISYLATE IN TABLETS BY HPLC

https://doi.org/10.22146/ijc.21610

Lestyo Wulandari(1*)

(1) Department of Chemical Pharmacy, School of Pharmacy, Jember University, Jl. Kalimantan I/2, Jember, 68121
(*) Corresponding Author

Abstract


An accurate and sensitive HPLC method has been developed for the determination of mebhydroline napadisylate in the tablet. The Chromatography was performed on a reversed phase C-18 column, using a mobile phase of acetonitrile : ammonia 25% (80 : 20 v/v) at ambient temperature 25±5 °C and UV detection operates at 320 nm in an overall analysis time of about 15 min, based on peak area. This HPLC method is selective, precise, and accurate and can be used for routine analysis of pharmaceutical preparation in industrial quality-control laboratories.

 

Keywords : HPLC, mebhydroline napadisylate, validation

Full Text:

Full Text Pdf



DOI: https://doi.org/10.22146/ijc.21610

Article Metrics

Abstract views : 292 | views : 516


Copyright (c) 2010 Indonesian Journal of Chemistry

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

 


Indonesian Journal of Chemisty (ISSN 1411-9420 / 2460-1578) - Chemistry Department, Universitas Gadjah Mada, Indonesia.

Web
Analytics View The Statistics of Indones. J. Chem.