SYNTHESIZE AND CITOTOXICITY TEST OF SEVERAL COMPOUNDS OF MONO PARA-HIDROXY CHALCON

https://doi.org/10.22146/ijc.21489

Indyah Sulistyo Arty(1*)

(1) Chemistry Education Department, FMIPA, Yogyakarta State University, Karangmalang Depok, Yogyakarta 55283
(*) Corresponding Author

Abstract


Five compounds of mono para-hidroxy chalcon were synthesized (TC1, TC2, TC3, TC4, and TC5) and tested their cytotoxicity against HeLa cell and Raji cell. The difference in substituent of TC1 (R4 =H), TC2 (R4 = OCH3), and TC3 (R4 = F), showed the difference of their citotoxicity against HeLa cell. The citotoxicity of TC1 (LC50 = 16.08 µg/mL) ≈ TC3 (LC50 = 13.37 µg/mL), but the substituent difference of TC2 (LC50 = 147.43 µg/mL), decreasing it citotoxicity 10 times. Like wise their citotoxicity against Raji cell of TC1 (LC50 = 36.44 µg/mL) ≈ TC3 (LC50 = 30.46 µg/mL), but the substituent difference of TC2 (LC50 = 468.94 µg/mL), decreasing it citotoxicity activity 15 times. Nevertheless the strength of citotoxicity TC4 (LC50 = 98.74 µg/mL) and TC5 (LC50 = 110.97 µg/mL) against Raji cell are stronger than the citotoxicity of two of them against HeLa cell (LC50 of TC4 = none, LC50 of TC5 = 576.53 µg/mL).


Keywords


mono para-hidroxy chalcon; HeLa cell; Raji cell; citotoxicity activity

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References

[1] Batt, D.G., 1992, Prog. Med. Chem., 29, 1-63.

[2] Hogale, M.B., Dhore, M.P., Shelar, A.R., and Pawar, P.K., 1986, Orient. J. Chem., 2, 55-57.

[3] Ninomiya, Y., Shimma, N., and Ishitsuka, H., 1990, Antivir. Res., 13, 2, 61-74.

[4] Torigu, T., Arinawa, M., Itoh, S., Fujio, M., and Maruyama, H.B., 1983, Biochem. Biophys. Res. Commun., 112, 833-842.

[5] Rao, M.N.A., Naidoo, L., and Ramanan, P.N., 1991, Pharmazie, 46, 7, 542-543.

[6] Shibata, S., Inoue, H., Iwata, S., Ma, R., Yu, L., Ueyama, H., Takayasu, J., Hasegawa, T., Tokuda, H., Nishino,, A., Nishino H., and Iwashima, A., 1991, Planta Med., 57, 221-224.

[7] Afzal, S., Asad, M.K., Rumana, Q.F., Ansari, Muhammad, F.N., and Syed, S.S., 2008, Int. J. Mol. Sci., 9, 1424-1434.

[8] Boumendjel, A., Ronot, X., and Boutonnat, J., 2009, Curr. Drug Targets, 10, 4, 363-371.

[9] Shapiro, G.I., and Harper, J.W., 1999, J. Clin. Investig., 104, 12, 1645-1653.

[10] Lee, Y.S., Lim, S.S., Shin, K.H., Kim, Y.S., Ohuchi, K., and Jung, S.H., 2006, Biol. Pharm. Bull., 29, 1028-1031.

[11] Sasayama, T., Tanaka, K., Mizukawa, K., Kawamura, A., Kondoh, T., Hosoda, K., and Kohmura, E., 2007, J. Neu-Onc., 85, 123-132.

[12] Ye, C.L., Liu, J.W., Wei, D.Z., Lu, Y.H., and Qian, F., 2004, Pharmacol. Res., 50, 505-510.

[13] Ye, C.L., Liu J.W., Wei, D.Z., Lu, Y.H., and Qian, F., 2005, Cancer Chemother. Pharmacol., 55, 447-452.

[14] Toshio, M, Wang, L-B., Nakamura, S., Ninomiya, K., Yokoyama, E., Matsuda, H., Muraoka, O., Wu, L-J., and Yoshikawa, M., 2009, Chem. Pharm. Bull., 57, 4, 361-367.

[15] Arty, I.S., Timmerman, H., Samhudi, M., Sastrohamidjojo, Sugiyanto, and van der Goot, H., 2000, Eur. J. Med. Chem., 35, 449-457.

[16] Arty, I.S., 2007, Proceeding of The International Symposium on the Recent Progress in Curcumin Research, 1st ed., 197-204.

[17] Lazer, E.S., Wong, H.C., Wegner, C.D., Graham, A.G., and Farina P.R., 1990, J. Med. Chem., 33, 1892-1898.

[18] Arty, I.S., and Handayani, S., 2007, Proceeding of International Seminar, ITB-UKM.

[19] Handayani, S., and Arty, I.S., 2008, J. Phys. Sci., 19, 2, 61-68.

[20] Sogawa, S., Nihro, Y., Ueda, H., Izumi, A., Miki, T., Matsumoto, H., and Satosh, H., 1993, J. Med. Chem., 36, 3904-3909.

[21] Castel, J.V., Jover, R., Gomes Lechon, M.J., Ponsoda, X., and Bort, R., 1997, In vitro investigation of the molecular mechanisms of hepatotoxicity. In: In Vitro Methods in Pharmaceutical Research, Academic Press, London, 375-410.

[22] Gibbs, J.B., 2000, J. Clin. Investig., 105, 9-13.

[23] Boyer, M.J., and Tannock, I.F., 2005, The Basic Science of Oncology; Cellular and Molecular Basis of Drug Treatment for Cancer Mc Graw Hill Company, 4th ed., New York.

[24] Nurrochmad, A., 2001, Thesis, Program Pascasarjana UGM, Yogyakarta

[25] Muhammad Da’i, 2003, Thesis, Program Pascasarjana UGM, Yogyakarta.



DOI: https://doi.org/10.22146/ijc.21489

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