SYNTHESIS OF POLYETHYLENE OXIDE (PEO)–CHITOSAN HYDROGEL PREPARED BY GAMMA RADIATION TECHNIQUE

https://doi.org/10.22146/ijc.21413

Erizal Erizal(1*), Thamrin Wikanta(2)

(1) Centre for the Applications Isotope and Radiation Technology, National Nuclear Agency, Jl. Lebak Bulus Raya no.49, Jakarta 12440
(2) Centre Research for Product Processing and Biotechnology Marine & Fisheries, Jl. K.S. Tubun VI, Jakarta 10260
(*) Corresponding Author

Abstract


Crosslinked PEO hydrogel containing chitosan for wound dressing has been prepared by gamma radiation technique. Chitosan solutions with different concentration (0.5-2% w/v) have been blended with 5% aqueous solution of PEO and irradiated at the doses 20-40 kGy by gamma rays. The copolymers were characterized by Fourier transform infra red spectroscopy and their physico-chemical properties of hydrogels were evaluated in terms of gel fraction, swelling ratio, elongation at break and antimicrobial activities. It was found that under maximum condition of incorporation 1% chitosan with irradiation dose of 20 kGy, PEO-chitosan hydrogels with high gel fraction (85%), swelling ratio (10 g/g) and elongation at break (145%) were obtained. The examination of the microbe penetration shows that the prepared hydrogels can be considered as a good barrier against microbes. Thus, PEO-chitosan hydrogel showed satisfactory properties for use as a wound dressing.

Keywords


Gamma radiation; polyethylene oxide; chitosan; hydrogel; wound dressing

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DOI: https://doi.org/10.22146/ijc.21413

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