SYDNONE DERIVATIVES A SYNTHONS FOR NOVEL MESOIONIC COMPOUNDS. SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL EVALUATION OF SOME 2-(4`-SUBSTITUTED ANILINOSYNDON-3`-YL)-1, 3, 4-THIADIAZINO (6, 5-B) INDOLES

https://doi.org/10.22146/ijc.21380

Hemant Panwar(1*), Shishupal Singh(2), Nidhi Chaudhary(3)

(1) Depatment of Chemistry, Neelkanth Institute of Technology, Modipuram-250110, Meerut, U.P.
(2) Department of Chemistry, Aligarh Muslim University, Aligarh-202002, U.P.
(3) Department of Chemistry, I.I.M.T., I.E.T., Ganga Nagar, Meerut-250001, U.P.
(*) Corresponding Author

Abstract


In the present study, a series of 2-(4´-Substitutedanilinosydnon-3´-yl)-1, 3, 4-thiadiazino (6, 5-b) indoles 7a-j have been synthesized. All the synthesized compounds have been characterized by elemental and spectral (I R, 1H- NMR and Mass) spectrometric analysis. Furthermore, above mentioned compounds were evaluated for their antibacterial and antifungal activities against selected panel of pathogenic strains. Ampicillin trihydrate, ofloxacin and fluconazole, griseofulvin were used as standard drugs for antibacterial and anifungal activity respectively. Compound 7j was found the most potent one with lesser toxicity in the prepared indole derivatives.

Keywords


Indoles; Antifungal; Antibacterial; Acute toxicity

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DOI: https://doi.org/10.22146/ijc.21380

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Indonesian Journal of Chemisty (ISSN 1411-9420 / 2460-1578) - Chemistry Department, Universitas Gadjah Mada, Indonesia.

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