Cytotoxic Isobractatin (Prenylated Xanthone) Epimer Mixture of Garcinia eugenifolia

https://doi.org/10.22146/ijc.21239

Sri Hartati(1*), I Ketut Triyono(2), Sri Handayani(3)

(1) Research Center for Chemistry - Indonesian Institute of Sciences (LIPI), Kawasan PUSPIPTEK Serpong, Tangerang Selatan, Banten 15314
(2) High School 96 Jakarta, Jl. Jati Raya No. 40, Cengkareng Barat, Jakarta Barat, DKI Jakarta 11840
(3) Research Center for Chemistry - Indonesian Institute of Sciences (LIPI), Jl. Cisitu – Sangkuriang Bandung 40135
(*) Corresponding Author

Abstract


In search of bioactive anti-cancer compounds from natural products has been found isobractatin from n-hexane extract of Garcinia eugenifolia. Isolation was done through the stages of maceration and column chromatography. Elucidation of the structure was analyzed by spectroscopy of UV-Vis, FTIR, LC-MS, NMR proton and carbon one and two dimension data. The results found three compounds isolated from G. eugenifolia. The three compounds were stigmasterol, prenylated xanthone isobractatin and its epimer (in a mixture). The mixture of isobractatin and its epimer showed cytotoxic activity against breast cancer cell line T47D with IC50 = 17 µg/mL.

Keywords


Garcinia eugenifolia; isobractatin; epimer; breast cancer; T47D cells

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DOI: https://doi.org/10.22146/ijc.21239

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Indonesian Journal of Chemisty (ISSN 1411-9420 / 2460-1578) - Chemistry Department, Universitas Gadjah Mada, Indonesia.

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