Hydrogel Based on Crosslinked Methylcellulose Prepared by Electron Beam Irradiation for Wound Dressing Application


Ambyah Suliwarno(1*)

(1) Center of Isotopes and Radiation Application–National Nuclear Energy Agency (BATAN), Jl. Lebak Bulus Raya No 49 Jakarta 12440
(*) Corresponding Author


The aim of this research is to explore the possibility of methylcellulose polymer to be used as wound dressing material prepared using electron beam technique. The methylcellulose paste solution with various of molecular weight (SM-4, SM-100, SM-400, SM-4000 and SM-8000) at different concentration (15-30% w/v) were irradiated by using electron beam on the dose range of 10 kGy up to 40 kGy. Gel fraction and swelling ratio of hydrogels were determined gravimetrically. Tensile strength and elasticity of hydrogels were measured using a universal testing machine. It was found that with the increasing of irradiation dose from 10 up to 40 kGy, gel fraction and tensile strength were increased for all of hydrogels with various of molecular weight. On contrary, the swelling ratio of hydrogels decreased with increasing of irradiation dose. The optimum hydrogels elasticity were obtained from methylcellulose solution with the concentration range of 15-20% with irradiation dose of 20 kGy and showed excellent performance. The hydrogels based on methylcellulose prepared by electron beam irradiation can be considered for wound dressing material.


methylcellulose; molecular weight; electron beam irradiation; wound dressing

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[1] Anonymous, http://en.wikipedia.org/wiki/Methylcellulose, accessed on January 2014.

[2] Sannino, A., Demitri, C., and Madaghiele, M., 2009, Materials, 2 (2), 353–373.

[3] Rimdusit, S., Somsaeng, K., Kewsuwan, P., Jubsilp, C., and Tiptipakorn, S., 2012, Eng. J., 16 (4), 2–14.

[4] Wach, R.A., Mitomo, H., Nagasawa, N., and Yoshii, F., 2003, Nucl. Instrum. Methods Phys. Res., 211 (4), 533–544.

[5] Anonymous, http://us.elsevierhealth.com/.../978075 0688079.p., Wound dressings and Bandages-Elsevier, accessed on February 2014.

[6] Weller, C., and Sussman, G., 2006, J. Pharm. Pract. Res., 36, (4), 318–324.

[7] Zahedi, P., Rezaeian, I., Ranaei-Siadat, S-O., Jafari, S-H., and Supaphol, P., 2010, Polym. Adv. Technol., 21 (22), 77–95.

[8] Anonymous, http://en.wikipedia.org/wiki/Ubbelohde_ viscometer, accessed on January 2014.

[9] Suliwarno A., 2009, Jaringan Kerjasama Kimia Indonesia, Yogyakarta, 339–342.

[10]Lott, J.R., McAllister, J.W., Arvidson, S.A., Bates, F.S., and Lodge, T.P., 2013, Biomacromolecules, 14 (8), 2484–2488.

[11]Rosiak, J.M., Janik, I., Kadlubowski, S., Kozicki, M., Kujawa, P., Stasica, P., and Ulanski P., 2002, “Radiation Formation of Hydrogels for Biomedical Application” in Radiation Synthesis and Modification of Polymers for Biomedical Applications, IAEA-TECDOC-1324, Vienna-Austria, 5–47.

[12]Yang, F., Li, G., He, Y-G., Ren, F-X., and Wang, G-X., 2009, Carbohydr. Polym., 78 (1), 95–99.

[13]Bajpai, A.K., and Giri, A., 2002, React. Funct. Polym., 53 (2-3), 125–141.

[14]Abdurrahmanoglu, S., Can, V., and Okay, O., 2009, Polymer, 50 (23), 5449–5455.

[15]Wach, R.A., Mitomo, H., Kudoh, H., Muroya, Y., Katsumura, Y., and Yoshii, F., 2005, Proceeding of the 8th Polymers for Advanced Technologies International Symposium, Budapest, Hungary, 13-16.

[16]Ahmed, E.M., 2013, J. Adv. Res., DOI: 10.1016/j.jare.2013.07.006.

[17]Rinaudo, M., 2010, Polymers, 2 (4), 505–521.

[18]Patel, T.R., Morris, G.A., de la Torre, J.G., Ortega, A., Mischnick, P., and Harding, S.E., 2008, Macromol. Biosci., 8 (12), 1108–1115.

[19]Suliwarno, A., 2013, Indo. J. Mater. Sci., 15 (1), 40–44.

DOI: https://doi.org/10.22146/ijc.21237

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