Synthesis and Characterization of Chitosan- Alginate for Controlled Release of Isoniazid Drug

Sari Edi Cahyaningrum(1*), Nuniek Herdyastuti(2), Nur Qomariah(3)

(1) Department of Chemistry, Faculty of Mathematics and Natural Sciences, Surabaya State University, Jl. Ketintang Surabaya 60231
(2) Department of Chemistry, Faculty of Mathematics and Natural Sciences, Surabaya State University, Jl. Ketintang Surabaya 60231
(3) Department of Biology, Faculty of Mathematics and Natural Sciences, Surabaya State University, Jl. Ketintang Surabaya 60231
(*) Corresponding Author


The aim of this research was to synthesize and characterize chitosan-calcium alginate as matrix isoniazid encapsulation to produce controlled release isoniazid drug. The microparticles were evaluated for surface morphology, functional groups, size particles, drug content and swelling index. The drug release kinetic was investigated at gastric and intestinal artificial pH. The results showed that isoniazid-calcium alginate-chitosan has majority particle diameter of 1001-1500 nm. The release mechanism of isoniazid was through combination of erosion and diffusion.


chitosan alginate; controlled release; isoniazid

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