Preparation of Citric Acid Crosslinked Chitosan/Poly(Vinyl Alcohol) Blend Membranes for Creatinine Transport

Retno Ariadi Lusiana(1*), Dwi Siswanta(2), Mudasir Mudasir(3)

(1) Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Diponegoro, Jl. Prof. Soedarto, Tembalang Semarang 50275
(2) Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Gadjah Mada, Sekip Utara, Yogyakarta 55281
(3) Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Gadjah Mada, Sekip Utara, Yogyakarta 55281
(*) Corresponding Author


Preparation of membrane using crosslinking reaction between chitosan and citric acid showed that functional group modification increased the number of active carrier groups which lead to better transport capacity of the membrane. In addition, the substitution of the carboxyl group increased creatinine permeation of chitosan membrane. The transport capacity of citric acid crosslinked chitosan membrane for creatinine was found to be 6.3 mg/L. The presence of cyanocobalamin slightly hindered the transport of creatinine although compounds did not able to pass through citric acid crosslinked chitosan/poly(vinyl alcohol) blend membrane, as compounds no found in the acceptor phase.


hemodialysis; crosslinked; active carrier; transport; membrane

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