Application of the Sono-Fenton Process for Doxycycline Degradation Using Taguchi’s Experimental Designs

Nabila Boucherit; Barki Mohamed; Achouak Madani; Abdelkarim Brahimi; Nassiba Mimi

doi:10.22146/ijc.102531

Application of the Sono-Fenton Process for Doxycycline Degradation Using Taguchi’s Experimental Designs

https://doi.org/10.22146/ijc.102531

Nabila Boucherit^(1*), Barki Mohamed⁽²⁾, Achouak Madani⁽³⁾, Abdelkarim Brahimi⁽⁴⁾, Nassiba Mimi⁽⁵⁾

(1) Department of Material Sciences, Faculty of Sciences, University of Medea, Urban Pole, Medea 26000, Algeria; Laboratory of BioMaterials and Transport Phenomena, Urban Pole, Medea 26000, Algeria
(2) University of Tizi Ouzou, Tizi Ouzou 15000, Algeria
(3) Laboratory of BioMaterials and Transport Phenomena, Urban Pole, Medea 26000, Algeria
(4) El-Birine Research Center (CRNB), COMENA, BP180 Ain Oussera, Djelfa 17000, Algeria
(5) Department of Material Sciences, Faculty of Sciences, University of Medea, Urban Pole, Medea 26000, Algeria
(*) Corresponding Author

Abstract

This study aimed to evaluate the effectiveness of the sono-Fenton method via the oxidation of a tetracycline antibiotic molecule: doxycycline hyclate (DXC), chosen as a model compound due to its regular detection in wastewater treatment plant effluents. Taguchi's statistical method was applied via the orthogonal and full experimental designs to optimize the influential parameters. The study’s results showed that the concentration of the oxidizing agent (H₂O₂) was the most effective factor for DXC degradation. The optimum conditions for antibiotic removal were initial DXC concentration at level 1 (0.5 mg L⁻¹), H₂O₂ concentration at level 2 (1.25 mM), and catalyst concentration at level 2 (0.65 mM). The results showed that the value predicted theoretically and determined via a matrix model for degradation efficiency was confirmed by the experimental value, which deviated by 3.11%. The various products obtained, characterized by UV-vis and HPLC, showed the transformation of DXC molecules by sono-Fenton oxidation.

Keywords

doxycycline; modelling; oxidation; Taguchi; toxicity

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DOI: https://doi.org/10.22146/ijc.102531