Development and Evaluation of Anti-Gout Jam Formulation from Jamaican Cherry (Muntingia calabura) and Stevia (Stevia rebaudiana Bertoni): Antioxidant Activity and Uric Acid Reduction Potential
Rizka Nurjanah(1*), Yuliana Debora Anggraini(2)
(1) Department of Oil Palm Processing Engineering Akademi Komunitas Perkebunan Yogyakarta, Jl. Petung No. 2, Papringan 55281, Indonesia
(2) Department of Oil Palm Processing Engineering Akademi Komunitas Perkebunan Yogyakarta, Jl. Petung No. 2, Papringan 55281, Indonesia
(*) Corresponding Author
Abstract
This study examines the potential of Jamaican cherry (JC) and stevia, a natural sweetener, as an anti-gout jam. It aims to evaluate the effects of JC leaf and stevia extracts on the jam’s chemical, physical, and organoleptic qualities, finding the optimal formulation and ascertaining whether feeding JC jam lowers mice’s blood uric acid levels. A complete block design with two factors was applied. The two factors were JC leaf extract (A1: 30%, A2: 50%, A3: 70%) and stevia extract (B1: 1%, B2: 2%, B3 3%). The findings indicate that, while there was no significant shift in the jam’s viscosity, sugar reduction, color, flavor, aroma, or spreadability, adding more JC leaf extract did affect its pH and moisture content. Similarly, stevia extract did not affect flavor, color, spreadability, viscosity, and sugar reduction, but it significantly impacted pH, moisture content, and aroma. The ideal jam formulation was a blend of 70% JC leaf extract (A3) and 3% stevia extract (B3), with a preference score of 4.66 (neutral), a viscosity of 387.50 cP, a pH of 4.16, a moisture content of 59.38%, and a sugar reduction of 1.85%. According to the results of the in vitro test, the JC jam successfully lowered uric acid levels to normal conditions at 4.92 mg/dL.
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Ahmad, L., Une, S., & Bait, Y., 2018. Karakteristik Komponen Gizi, Antioksidan, dan Respon Organoleptik Bubur Jagung Tradisional Gorontalo dengan Ekstrak Daun Kersen (Muntingia calabura L.). [Nutrient characteristic, antioxidant and organoleptic respond of Gorontalo traditional commeal with cherry leaves fortificant (Muntingia calabura L.)]. Agritech, 38 (4), 463–468. https://doi.org/10.22146/agritech.28670
Alvianti, N., & Fitri, K., 2018. Formulation of cream anti acne substances leaf kersen (extract etanol Muntingiacalabural.). Jurnal Dunia Farmasi, 3(1), 24–31. https://doi.org/10.33085/jdf.v3i1.4418
Andragogi, V., Bintoro, P. V., & Susanti, S., 2018. Effects of different types of sugar on the sensory properties and nutritional value of sweet bread. Jurnal Teknologi Pangan, 2(2), 163–167.
Apriani, D., 2013. Studi tentang nilai viskositas madu hutan dari beberapa daerah di sumatera barat untuk mengetahui kualitas madu. [Study on the viscosity value of forest honey from several regions in West Sumatra to determine the quality of honey]. Pillar of Physics, 2(1).
Arthritis Australia. (n.d.). Allopurinol. https://arthritisaustralia.com.au/medication-search/allopurinol/#
Buchori, L., 2007. Pembuatan Gula Non Karsinogenik Non Kalori dari Daun Stevia. [Manufacture of non-carcinogenic, non-caloric sugar from stevia leaves]. Reaktor, 11(2), 57–60. https://doi.org/10.14710/reaktor.11.2.57-60
Fadhilah, A. R., Widyastuti, S., & Nazaruddin., 2024. Effect of carrageenan and chocolate concetration on the microbiological, chemical and organoleptic quality of banana kepok (Musa paradisiacal L.) fruit roll. EduFood, 2(2), 78–88.
Hananto, G., & Setiadi, A., 2024. Tinjauan sistematis faktor risiko kejadian batu ginjal asam urat. [Systematic review of risk factors for uric acid kidney stone incidence]. Intisari Sains Medis, 15(2), 886–895. https://doi.org/10.15562/ism.v15i2.2067
Harefa, W., & Pato, U., 2017. Evaluation of level fruit maturity to quality of kepok banana flours that produced. Jom FAPERTA, 4(2).
Hidayanto, A., Manikam, A. S., Pertiwi, W. S., & Harismah, K., 2017 Mouthwash Formulation of Basil Leaf Extract (Ocimum Basilicum L) with Natural Sweetener Stevia (Stevia Rebaudiana Bertoni). University Research Colloquium, 189–194.
Ilkafah, 2018a. Daun kersen (Muntingia Calabura L.) sebagai alternatif terapi pada penderita gout artritis. Jurnal Farmasi Medica/Pharmacy Medical Journal (PMJ), 1(1).
Ilkafah, I., 2018b. Daun Kersen (Muntingia calabura L.) Sebagai Alternatif Terapi Pada Penderita Gout Artritis. [Jamaican cherry leaf (Muntingia calabura L.) as an alternative therapy for patients with gouty arthritis]. Pharmacy Medical Journal, 1(1). https://doi.org/10.35799/pmj.1.1.2018.19649
Islamika, M. F., Sobah, N., & Narsa, A. C., 2023. Characteristics of kersen leaf extract (Muntingia calabura L.) as a candidate active ingredient in sleeping mask gel formulation. Proceeding of Mulawarman Pharmaceuticals Conferences, 18(1), 97–102. https://doi.org/10.25026/mpc.v18i1.711
Johnson, R. J., Sanchez Lozada, L. G., Lanaspa, M. A., Piani, F., & Borghi, C., 2023. Uric acid and chronic kidney disease: still more to do. In Kidney International Reports (Vol. 8, Issue 2). https://doi.org/10.1016/j.ekir.2022.11.016
Kholifaturrokhmah, I., & Purnawati, R. D., 2016. Pengaruh Pemberian Ekstrak Buah (Muntingia calabura L.) Dosis Bertingkat Terhadap Gambaran Histopatologi Ginjal Mencit BALB/C yang Hiperurisemia. [Effect of administration of graded doses of kersen fruit extract (Muntingia Calabura L.) on the histopathological picture of the kidneys of hyperuricemia Balb/c mice]. Jurnal Kedokteran Diponegoro, 5(3), 199–209.
Laswati, D. T., Sundari, N. R. I., & Anggraini, O. (2018). Utilization of cherry (Muntingia calabura L.) as a alternative food processed products: chemical and sensory properties. Jurnal JITIPARI, 4, 127–134.
Meiliza, E. R., 2013. Pengaruh Jus Buah Kersen (Muntingia calabura L) terhadap Kadar Asam Urat Darah pada Tikus (Mus musculus). [Effect of Kersen Fruit Juice (Muntingia calabura L) on Blood Uric Acid Levels of Mice (Mus musculus)]. Universitas Muhammadiyah Surakarta.
Murtadha, A., Julianti, E., & Suhaidi, I., 2012. Pengaruh perangsang pematangan terhadap kualitas buah pisang barangan (Musa paradisiaca L.). [Effect of ripening inducers on fruit quality of barangan banana (Musa paradisiaca L.)]. Jurnal Rekayasa Pangan Dan Pertanian, 1(1), 47–56.
Nasrul, E., & Sofitri, S., 2012. Hiperurisemia pada pra diabetes. Jurnal Kesehatan Andalas, 1(2).
National Standardization Agency. (1995). SNI-01-3745-1995: Selai. [Fruit Jam]. National Standardization Agency
Noorhamdani, Y. R., 2014. Pengujian Ekstrak Daun Muntingia calabura Jamaika sebagai Antibakteri Terhadap Staphylococcus aureus yang Resisten terhadap Metisilin (MRSA) In Vitro. [Test of Jamaican Extract Leaf Extract (Muntingia calabura) as an Antibacterial Against Methicillin-Resistant Staphylococcus aureus (MRSA) In Vitro]. Laboratorium Fakultas Kedokteran.
Rosida, D. F., 2011. Reaksi Maillard: Mekanisme dan Perannya dalam Makanan dan Kesehatan. [Maillard Reaction: Mechanisms and Roles in Food and Health]. Yayasan Humaniora.
Singh, J., Kaur, Dr. S., Kaur, M., & Verma, Dr. M. K., 2022. The role of uric acid as an antioxidant in selected neurodegenerative disease pathogenesis. International Journal of Scientific Research in Science and Technology, 9(4), 239–247. https://doi.org/10.4172/2168-975x.1000129
Siregar, M. L., & Nurkhalis., 2015. Correlation between serum blood glucose with serum uric acid in type 2 diabetes mellitus masra. Idea Nursing Journal, VI(3), 27–33.
Wang, H. Y., Qian, H., & Yao, W. R., 2011. Melanoidins produced by the Maillard reaction: Structure and biological activity. Food Chemistry, 128(3), 573–584. https://doi.org/10.1016/j.foodchem.2011.03.075
Winarno, F. G., 2008. Kimia Pangan dan Nutrisi. [Food Chemistry and Nutrition]. PT. Gramedia Pustaka Utama.
Wirawan, & Mushollaeni, W., 2008. Optimasi waktu blansing untuk pengolahan selai kacang menggunakan metode regresi kuadratik. [Optimization of blanching time for peanut butter processing using quadratic regression method]. Buana Sains, 8(1), 73–80.
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