Cosmetic Serum Loaded Arabica Coffee (Coffea arabica) Extract: Formulation and Antioxidant Study

https://doi.org/10.22146/mot.83120

Harum Nadyanti Usman(1), Liza Pratiwi(2*), Bambang Wijianto(3)

(1) Pharmacy Department, Faculty of Medicine, Tanjungpura University, Pontianak, Kalimantan Barat
(2) Pharmaceutical Technology Departement, Pharmacy Department, Medical Faculty, Tanjungpura University, Pontianak, Kalimantan Barat
(3) Pharmaceutical Chemistry Departement, Pharmacy Department, Medical Faculty, Tanjungpura University, Pontianak, Kalimantan Barat
(*) Corresponding Author

Abstract


Arabica coffee (Coffea arabica) is a natural antioxidant that can be used in the prevention of skin aging. This study was conducted to determine the comparison of variations in the composition of HPMC, CMC-Na, and Carbomer in the optimum formula of arabica coffee serum, then to determine the physical properties of the preparation, as well as the IC50 value ofarabica coffee extract and arabica coffee serum in the DPPH test. Arabica coffee extract was obtained by maceration method using 70% ethanol. Determination of the optimum formula of arabica coffee serum using the Simplex Lattice Design method. The optimum formula of arabica coffee serum was evaluated for physical properties including organoleptic test, homogeneity test, pH test, spreadability test, and adhesion test. The antioxidant activity of arabica coffee extract and the optimum formula of arabica coffee serum was tested using the DPPH method. Data analysis used SPSS One sample T-test statistics. The results showed that the composition variation of HPMC, CMC-Na, and Carbomer in the optimum formula of arabica coffee serum using the Simplex Lattice Design method was 0.1%:0.8%:0.1%. The resulting predicted values are a pH value of 4.88 and a spreadability value of 7.95 cm. The optimum formula of arabica coffee serum has the physical properties of the preparation, namely brown color, coffee aroma, light texture, a cool sensation when applied to the skin, homogeneous, has a spreadability of 7.93 cm, stickiness of 1 second, and pH value of 4.9. The IC50 value of arabica coffee extract and the optimum formula of arabica coffee serum are 8.13 ppm and 250 ppm. The results of the SPSS One sample T-test statistical analysis showed that there was no significant difference between the prediction response and the results of the optimum formula evaluation.


Keywords


Arabica Coffee; Antioxidant; Serum; Simplex Lattice Design

Full Text:

PDF


References

Afianti, P.H. 2015. Pengaruh Variasi Kadar Gelling Agent HPMC terhadap Sifat Fisik dan Aktivitas Antibakteri Sediaan Gel Ekstrak Etanolik Daun Kemangi (Ocimum basilicum L. forma citratum Back.). Majalah Farmaseutik, 11(2), 307.

Ahmad, Z., & Damayanti. 2018. Penuaan Kulit : Patofisiologi dan Manifestasi Klinis. Berkala Ilmu Kesehatan Kulit dan Kelamin, 30(3), 208–15.

Ajhar, N.M., & Meilani, D. 2020. Skrining Fitokimia Dan Uji Aktivitas Antioksidan Dari Ekstrak Etanol Biji Kopi Arabika (Coffea arabica) Yang Tumbuh Di Daerah Gayo Dengan Metode DPPH. Jurnal Ilmiah Farmasi, 5(1), 34–40.

Asky, S., Rukaya, B.E., Mustamin, F. 2022. Uji stabilitas fisik serum anti-aging ekstrak etil asetat daun cempedak (Arthocarpus champeden Spreng.). Jurnal Borneo, 2(2), 50–8.

Aulifa, D.L., Caroline, M., Tristiyanti, D., & Budiman, A. 2020. Formulation of the serum gel containing green coffee bean (Coffea robusta L) extract as an antioxidant and tyrosinase enzyme inhibitor. Rasayan Journal Chem, 13(4), 2346–51.

Aziza, A.N., Harapan, P., & Tegal, B. 2022. Pengaruh Konsentrasi HPMC-Kitosan Terhadap Sifat Fisik dan Aktivitas Antioksidan Serum Ekstrak Pegagan (Centella asiatica L . Urban). Jurnal Insan Cendekia, 9(1):9–19.

Darmawan, A.B. 2013. Anti-Aging Rahasia Tampil Muda di Segala Usia. Jakarta: Media Pressindo.

Dewi, Citra, C., & Saptarini, N.M. 2016. Review Artikel: Hidroksi Propil Metil Selulosa Dan Karbomer Serta Sifat Fisikokimianya Sebagai Gelling Agent. Pharmacon, 14(3), 1–10.

Dewiastuti, M., & Hasanah, I.F. 2017. Pengaruh Faktor-Faktor Risiko Penuaan Dini Di Kulit Pada Remaja Wanita Usia 18-21 Tahun. Jurnal Kedokteran dan Kesehatan, 10(1), 21–5.

Ginting, M., Fitri, K., Leny, L., Lubis, B.K. 2020. Formulasi dan Uji Efektifitas Anti-Aging dari Masker Clay Ekstrak Etanol Kentang Kuning (Solanum tuberosum L.). Jurnal Dunia Farmasi, 4(2), 68–75.

Hasanah, N., Indah, F.P.S., Anggraeni, D., Ismaya, N.A., & Puji, L.K.R. 2020. Perbandingan Formulasi Dan Uji Stabilitas Fisik Sediaan Gel Ekstrak Lidah Buaya (Aloe vera) Dengan Perbedaan Konsentrasi. Edu Masda Journal, 4(2), 132.

Hati, A.K., Dyahariesti, N., Yuswantina, R. 2021. Optimasi Formula Pasta Gigi Kombinasi Ekstrak Rimpang Temu Kunci dan Sereh dengan CMC-Na dan Carbomer sebagai Bahan Pengikat Menggunakan Metode Simplex Lattice Design. Jurnal Kefarmasian Indonesia, 11(1), 25–33.

Hidayat, I.R., Zuhrotun, A., & Sopyan, I. 2020. Design-Expert Software sebagai Alat Optimasi Formulasi Sediaan Farmasi. Majalah Farmasetika, 6(1), 99–120.

Hilda, D., Arini, A., & Nancy, C.D. 2021. Formulation of Body Scrub Cream From Extract of Arabika Green Coffee (Coffea arabica L.) Health Science Nurse, 33, 337–42.

Knaggs, H. 2008. Skin Aging in the Asian population. New York: William Andrew Publishing.

Marchianti, A.C.N., Sakinah, E.N., Elfiah, U., Putri, N.K.S., Wahyuliswari, D.I., Maulana, M., et al. 2021. Gel formulations of Merremia mammosa (Lour.) Accelerated Wound Healing of the Wound in Diabetic Rats. Journal of Traditional and Complementary Medicine, 11(1), 38–45.

Mardhiani, Y.D., Yulianti, H., Azhary, D., & Rusdiana, T. 2018. Formulasi dan Stabiltas Sediaan Serum dari Ekstrak Kopi Hijau (Coffe Canephora). Indonesia Natural Research Pharmaceutical Journal, 2(2):19–33.

Martiani, I., Azzahra, I.F., & Perdana, F. 2017. Antioxidant Activities of N-Hexan, Ethyl Acetate, and Methanol Extracts of Dewandaru Leaves (Eugenia uniflora L.). Jurnal Ilmiah Farmako Bahari, 8(2):31-39.

Muchtaridi, Rubiyanti, R., Nuruljanah, H., Laila, M., Asih, N., Moelyono, M.W., Nurhasanah, A., Musfiroh, I. 2017. Determination Of Parameters Standardization Crude Drug And Extract Arabica Coffee Beans (Coffea Arabica L.). International Journal Of Scientific & Technology Research, 6(2):61-70.

Nisa, K., & Surbakti, E.S.B. 2016. Tomat (Lycopersicum esculentum Mill.) sebagai Anti Penuaan Kulit. Majority, 5(3), 73–8.

Rohmani, S., Kuncoro, M.A.A. 2019. Uji Stabilitas dan Aktivitas Gel andsanitizer Ekstrak Daun Kemangi. JPSCR, 4(1), 16.

Santoso, A.B., Pagar, G.J., & Fisik, S. 2022. Pengaruh Kombinasi Gelling Agent Carbopol 934 Dan Natrium Carboxymethylcellulose (Na-CMC) Terhadap Stabilitas Fisik Gel Getah Jarak Pagar (Jatropha curcas) Sebagai Penyembuh. Duta Pharma Journal, 2(1), 8–24.

Tambunan, S., & Sulaiman, T.N.S. 2018. Formulasi Gel Minyak Atsiri Sereh Dengan Basis HPMC dan Karbopol. Majalah Farmaseutik, 14(2), 87–95

Taylor, S.C. 2005. Photoaging and Pigmentary Changes Of The Skin. New York: Springer.

Tilarso, D.P., Maghfiroh, A., & Amira, K.J. 2022. Pengaruh Gelling Agent pada Sediaan Serum Jerawat Kombinasi Ekstrak Daun Sirih Hijau dan Buah Belimbing Wuluh. Jurnal Farmasi Indonesia, 3(1):1–7.

Widyaningrum, N., Novitasari, M., Puspitasary, K. 2019. Perbedaan Variasi Formula Basis Cmc Na Terhadap Sifat Fisik Gel Ekstrak Etanol Kulit Kacang Tanah (Arachis hypogaea L). Avicenna Joutnal Health Research, 2(2), 121–34.



DOI: https://doi.org/10.22146/mot.83120

Article Metrics

Abstract views : 2056 | views : 2089

Refbacks

  • There are currently no refbacks.


Bookmark and Share


Copyright (c) 2023 Majalah Obat Tradisional

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

©Majalah Obat Tradisional (Traditional Medicine Journal)
 ISSN 2406-9086
Faculty of Pharmacy
Universitas Gadjah Mada