Preparation, Characterization, and Wound Healing Activity of Papaya Leaves Extract on Spray Gel

https://doi.org/10.22146/mot.53690

Dina Permata Wijaya(1*), Herlina Herlina(2), Najma Annuria Fitri(3), Mardiyanto Mardiyanto(4), Mustikasanti Mustikasanti(5), Firnando Firnando(6)

(1) Department of Pharmacy, Faculty of Science, Sriwijaya University, Indralaya, South Sumatera
(2) Department of Pharmacy, Faculty of Science, Sriwijaya University, Indralaya, South Sumatera
(3) Department of Pharmacy, Faculty of Science, Sriwijaya University, Indralaya, South Sumatera
(4) Department of Pharmacy, Faculty of Science, Sriwijaya University, Indralaya, South Sumatera
(5) Department of Chemistry, Faculty of Science, Sriwijaya University, Indralaya, South Sumatera, Indonesia
(6) Department of Pharmacy, Faculty of Science, Sriwijaya University, Indralaya, South Sumatera, Indonesia
(*) Corresponding Author

Abstract


Papaya leaves have been using for wound healing that contains flavonoids, saponins, phenolics, chymopapain, and papain enzymes. The aim of this research were preparation, characterization, and wound healing activity of papaya leaves extract on spray gel. Spray gel was formulated with variation of gelling agent such as carbopol 940, HPMC, gellan gum, and hydroxyethylcellulose. The spray gel were characterizated by organoleptic, pH, stickiness test, viscosity, homogeneity, weight, and wound healing activity in rats. The results showed were all of formula spray gel have brown and homogeneous, pH between 5,947-6,347 within pH range of skin, stickiness test between 1,92-8,12 s, viscosity between 880-1740 cPs. Papaya leaves extract on spray gel has wound healing activity in rats faster than extract and positive control that is 16 days. The wound healing of papaya leaves extract on spray gel exhibited significantly different (p<0,05) than negative control.


Keywords


Spray gel; papaya leaves; carbopol 940; HPMC; hydroxyethylcellulose

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References

Ansel, H. C, 1989, Pengantar bentuk sediaan farmasi, Edisi ke-4, UI Press, Jakarta, Indonesia.

Boateng, Joshua, C., Kerr, H. Matthews, Howard, N. E. Stevens, Gillian, M. Eccleston, 2008, Wound healing dressing and drug delivery system, Journal of Pharmaceutical Sciences, 97(8): 11.

Dahlizar, S., Futaki, M., Okada, M., Kadhum, W.R., Todo, H., Sugibayashi, K., 2018, Design of a topically applied gel spray formulation with ivermectin using novel low molecular weight gelling agent, palmitoyl-glycine-histidine, to traet scabies, Chem. Pharm. Bull, 327-333.

Femilian, A., Dewi, A., Goeno, S., 2019, The effect of papaya leaf (Carica papaya L) on healing process of buccal traumatic ulcer in wistar rats, Majalah Kedokteran Gigi Indonesia, 15-22

Gurtner, G.C. 2007. ‘Wound healing: normal and abnormal’. Edisi ke-6, Lippincott Williams & Wilkins, Philadelphia, USA.

Harahap, R., 2018, ‘Formulasi dan optimasi spray gel ekstrak etanol daun pepaya (Carica papaya Linn.) dengan basis kombinasi carbopol®940 dan gellan gum menggunakan desain faktorial’, Skripsi, S. Farm., Jurusan Farmasi, Fakultas MIPA, Universitas Sriwijaya, Indralaya, Indonesia.

Hatahet, T., Morille, M., Hammos, A., Devoissele, J.M., Muller, R.H., Begu, S., 2016, Quercetin topical application, from conventional dosage forms to nanodosage forms. European Journal of Pharmaceutics and Biopharmaceutics, 41-53

Lawrence, W.T, 2002, Wound healing biology and its application to wound management , Dalam: O’Leary P. ThePhysiologic Basis of Surgery, Edisi ke-3, Lippincott Williams & Wilkins, Philadelphia, USA.

Mahmood, A.A., K. Sidik, I. Salmah, 2005, Wound healing activity of Carica papaya L. aqueous leaf extract in rats, International Journal of Molucules Medicine and Advance Sciences, 398-401.

Marcovitch, H, 2005, ‘Black’s medical dictionary’. 41st edition, A&C Black, London, Inggris.

Rajab, Nawal A., 2013, Preparation and evaluation of ketoprofen as dermal spray film. Kerbala Journal of Pharmaceutical Sciences, 6.

Suyudi, S.D. 2014, ‘Formulasi gel semprot menggunakan kombinasi karbopol 940 dan hidroksipropil metilselulosa (HPMC) sebagai pembentuk gel’, Skripsi, S.Farm., Program Studi Farmasi, Fakultas Kedokteran dan Ilmu Kesehatan, UIN Syarif Hidayatullah Jakarta, Jakarta, Indonesia.



DOI: https://doi.org/10.22146/mot.53690

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