Effect of Swiftlet’s (Collocalia Fuciphago) Nest Extract on the Malondialdehyde (MDA) and Superoxyde Dismutase (SOD) Activity on Hyperglycemic Rattus Norvegicius


Francisca Diana Alexandra(1*), Agnes Frethernety(2), Elsa Trinovita(3), Triawanti Triawanti(4)

(1) Department of Pharmacology, Faculty of Medicine, Palangkaraya University, Palangkaraya, Central Kalimantan
(2) Department of Pharmacology, Faculty of Medicine, Palangkaraya University, Palangkaraya, Central Kalimantan
(3) Department of Pharmacology, Faculty of Medicine, Palangkaraya University, Palangkaraya, Central Kalimantan
(4) Department of Medical Chemistru/Biochemistry, Faculty of Medicine, Lambung Mangkurat University, South Kalimantan
(*) Corresponding Author


Hyperglycemia that occurs in diabetic Mellitus leads to glycation reactions in protein molecules and oxidative stress resulting in damage to cells and organs. Swiftlet’s nest believed society could lower blood glucose. The objective of the study was to evaluate the effect of Swiftlet’s nest (Collocalia fuciphago) extract on glucose level, Malondialdehyde (MDA) levels, and Superoxide Dismutase (SOD) activity in blood serum. The study used Posttest-Only with Control Group Design, consisting of 1 control group (given aqua dest) and 3 treatment groups (dose 1; 10 and 100 mg/kg BW). Each group consisted of 6 Rattus norvegicius. Before being treated, Streptozotocin-induced rat at a dose of 68 mg/kg BW intraperitoneal. On the 7th day after induction, rats had elevated glucose ± 102 - 108 mg/dL. Then the rats were given water extract Swiftlet’s nest for 28 days orally. All data were analyzed by the Kruskal-Wallis test, followed by the Mann-Whitney test, with a 95% confidence level. The results of blood glucose levels in each group (K, P1, P2 and P3) were 111.0 vs 88.5 vs 86 vs 83 mg / dL (p = 0.035), MDA levels experienced an increase in the treatment group compared to controls namely 193.50 vs 193.83 vs. 198.50 nmol / mL, p = 0.001. While the SOD enzyme activity has increased, namely 0.0050 vs. 0.0075 vs. 0.0263%. In conclusion, Swiftlet’s nest water extract can reduce blood glucose levels and increase MDA levels and SOD enzyme activity in blood serum. 


Hyperglycemia; MDA; SOD enzyme activity; Collocalia Fuciphago

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Alexandra FD et al., 2018, ‘Influence of Extract Swiftlet’s’s Nest (Collocalia fuciphago) as Antihyperglycemia to Circulating Endothelial Cells in Rat (Rattus novergicus) Induced by Streptozotocin, Jurnal Berkala Kedokterani. Vol.14 No.1(2018): Februari 2018; p.1-8.

Anuradha, C. V. 2009, ‘Aminoacid support in the prevention of diabetes and diabetic complications’, Current protein & peptide science, 10(1), 8–17.

Dal, S., & Sigrist, S., 2016, ‘The Protective Effect of Antioxidants Consumption on Diabetes and Vascular Complications’, Diseases (Basel, Switzerland), 4(3), 24.

Elfita L., 2014, ‘Analisis Profil Protein Dan Asam Amino Sarang Burung Walet (Collocalia fuchiphaga) asal Painan’, Jurnal Sains dan Farmasi Klinis. 1(1) 27-37

Fang, Y. Z., Yang, S., & Wu, G., 2002, ‘Free radicals, antioxidants, and nutrition’, Nutrition (Burbank, Los Angeles County, Calif.), 18(10), 872–879.

Hamzah, Z et al., 2013, ‘Nutritional properties of edible bird nest’, J Asian Sci Res. 3 vol. 3(6): 600-607,

Kim, K.C et al., 2012, ‘Water extract of edible bird’s nest attenuated the oxidative stress-induced matrix metalloproteinase-1 by regulating the mitogen-activated protein kinase and activator protein-1 pathway in human keratinocytes’. J Korean Soc Appl Biol Chem 55, 347–354.

Kementerian Kesehatan RI, 2013, Riset Kesehatan Dasar (Riskesdas) 2013, Badan Penelitian Dan Pengembangan Kesehatan Republik Indonesia, Jakarta

YC Kong et al., 1987, ‘Evidence that epidermal growth factor is present in Swiftlet’s’s's (Collocalia) nest’, Comparative Biochemistry and Physiology, 87(2), 221–226.

Liu Jian-Hua et al., 2011, ‘Characterization and In Vitro Antioxidation of Papain Hydrolysate From Black Bone Silky Fowl (Gallus gallus domesticus Brisson) Muscle and Its Fractions’, Food Research International, 44(11) 133-138

Ndraha, S, 2014, ‘Diabetes Melitus Tipe 2 dan Tatalaksana Terkini’. Departemen Penyakit Dalam Fakultas Kedokteran Universitas Kirda Wacana, Jakarta, 27(2):9-16.

Power O, Jakeman P dan FitzGerald RJ, 2013. Antioxidative peptides: enzymatic production, in vitro and in vivo antioxidant activity and potensial applications of milk-derivated antioxidative peptides. Amino Acid. (44): 797-820

Power, O., Jakeman, P., & FitzGerald, R. J, 2013, ‘Antioxidative peptides: enzymatic production, in vitro and in vivo antioxidant activity and potential applications of milk-derived antioxidative peptides’, Amino acids, 44(3), 797–820.

Setiawan B and Eko S, 2005, ‘Stres Oksidatif dan Peran Antioksidan pada Diabetes Melitus’. Majalah Kedokteran Indonesia. 55 (2): 87-90.

Ueno Y et al., 2002. Dietary glutathione protects ratsfrom diabetic nephropathy andneuropathy. The Journal of Nutrition. 2002:897-900

Ueno, Y et al., 2002, ‘Dietary glutathione protects rats from diabetic nephropathy and neuropathy’, The Journal of nutrition, 132(5), 897–900.

Van Loon LJC et al., 2003, ‘Amino acid ingestion strongly enhances insulin secretion in patients with long-term type 2 diabetes’, Diabetes Care. 26(3) 625-630

Jusman, S., & Halim, A., 2010, ‘Oxidative Stress in Liver Tissue of Rat Induced by Chronic Systemic Hypoxia’, Makara Journal Of Health Research, 13(1): 34-38.

Winarsih H. 2007. Antioksidan Alami dan Radikal Bebas: Potensi dan Aplikasinya dalam kesehatan. Yogyakarta: Kanisius

World Health Organization (WHO). 2018. Diabetes. Available from: http://www.who.int.

Zatalia, S. R., & Sanusi, H, 2013, ‘The role of antioxidants in the pathophysiology, complications, and management of diabetes mellitus’, Acta medica Indonesiana, 45(2), 141–147.

DOI: https://doi.org/10.22146/mot.53673

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