The Influence of Channa Striata Extract Emulgel on Incision Wound Healing in White Rats

https://doi.org/10.22146/mot.45080

Lucia Hendriati(1*), Suryo Kuncorojakti(2), Teguh Widodo(3), Heny Kristi Meitasari(4), Wilis Prasasti(5)

(1) Faculty of Pharmacy, Widya Mandala Catholic University, Surabaya, Indonesia
(2) Faculty of Veterinary, Airlangga University, Surabaya, Indonesia
(3) Faculty of Pharmacy, Widya Mandala Catholic University, Surabaya, Indonesia
(4) Faculty of Pharmacy, Widya Mandala Catholic University, Surabaya, Indonesia
(5) Faculty of Pharmacy, Widya Mandala Catholic University, Surabaya, Indonesia
(*) Corresponding Author

Abstract


Snakehead fish (Channa striata) have high albumin content, a protein needed for cell development and the formation of new tissue. The aim of this study was to determine the influence of snakehead fish extract emulgel given topically on incision wounds in white rats. The parameters of wound healing consist of wound length, a number of neutrophils, macrophages, fibroblasts and density of collagen. The white rats divide into three groups of (n = 6), one group was given the emulgel base as the negative control, one group of povidone-iodine as the positive control, and one group of snakehead fish extract 10% emulgel. White rats were sacrificed on the third and seventh days for microscopic observations. The results showed that snakehead fish extract emulgel can accelerate incision wound healing: decrease wound length, increase the number of neutrophil and macrophages cells, increase the average number of fibroblasts and increase collagen density on white rats.


Keywords


Channa striata; emulgel; healing; incision wounds

Full Text:

PDF


References

Nagori, B.D., & Solanki, R,. 2011, ‘Role of Medicinal Plants in wound Healing’, Research Journal of Medicinal Plants, 5, 392-405.

Orsted, H.L., Keast, D., Lalande, L.F. & Megie, M. Francoise., 2011, ‘Basic Priciples of Wound Healing: an understanding of the basic physiology of wound healing provides the clinician with the framework necessary to implement the basic principles of chronic wound care’, Wound Care Canada, 9, 4- 12.

Masir, Oky., Manjas, Mr., Putra, E.A. & Agus, S., 2012, ‘Pengaruh Cairan Cultur Filtrate Fibroblast (CFF) Terhadap Penyembuhan Luka, Penelitian eksperimental pada Rattus Norvegicus Galur Wistar’, Jurnal Kesehatan Andalas. 1, 112-117.

Crowe, T. C. & Brockbank, C. M., 2009, ‘Nutrition therapy in the prevention and treatment of pressure ulcers’, Wound Pratice and Research. 17, 90-99.

Sediaoetama, A.D, 2004, Ilmu Gizi untuk Mahasiswa dan Profesi. Jilid 1, Dian Rakyat, Jakarta.

Daud, C.K.D., Mat Jais, A.M., Ahmad, Z., Akim, AM.D. & Adam A., 2010, ‘Amino and acid compositions in Haruan traditional extract (HTE)’, Bol Latinoam Caribe Plant Med Aromat, 9, 414-429.

Sinambela, H.Y., 2012, ‘Optimasi Formulasi Sediaan Salep Minyak Ikan Gabus (Channa Striata Bloch) sebagai Obat Luka Sayat dengan Metode Simplex Lattice Design’, Skripsi, Program Studi Farmasi, Fakultas Kedokteran Universitas Tanjungpura Pontianak.

Yanhendri., Yenny, S. W., 2012., ‘Berbagai Bentuk Sediaan Topikal dalam Dermatologi’, Cermin Dunia Kedokteran, Universitas Andalas: Padang., Indonesia., 39, 423-430.

Brunton, L., Chabner, B., & Knollman, B, 2011, Goodman & Gilman: The Pharmacological Basic of Therapeutics., 12th ed., Mac Grill Hill, New York.

Bancroft, J.D, Layton,C. & Suvarna, S.K., 2013, Bancroft’s Theory and Practice of Histological Techniques, 7th ed., pp 15, Churchill Livingstone, Elsevier.

Gurtner, G.C., 2007, Wound Healing: Normal and Abnormal. In: Thorne C.H. (ed), Grab and Smith’s Plastic Surgery, 6 th ed., pp. 15-22, Lippincott Williams and Wilkins, Philadelphia.

Guyton, A. C., & Hall, J. E., 2006, Textbook Of Medical Physiology, Philadelphia: Elsevier Saunders.

Martini, F.H., Nath, J.L. & Bartholomew, E.F., 2012, Fundamentals Anatomy & Physiology, 9th ed., p 145-155, USA: Benjamin Cummings.

Yun, Y.R., Won, J.E., Jeon, W., Lee, S., Kang, W., Jo, H., Jang, J.H., Shin, U.S. & Kim, H.W., 2010, ‘Fibroblast Growth Factors: Biology, Function, and Application for Tissue Regeneration’, J Tissue Eng. 218142

Johnston, E.F. & Gillis, T.E., 2017, ‘Transforming growth factor beta-1 (TGF-β1) stimulates collagen synthesis in cultured rainbow trout cardiac fibroblasts’, Journal of Experimental Biology, 220, 2645-2653

Irwanda, W.F., Andrie, M. & Luliana, S., 2015, Uji Efek Penyembuhan Luka Fase Air Ekstrak Ikan Toman (Channa Micropeltes) Pada Tikus Putih Jantan Wistar Yang Diberi Luka Sayat, Jurnal Mahasiswa Farmasi Universitas Tanjungpura, 3, 1-14.

Mustafa, A., Widodo, M.A. & Kristanto, Y., 2012, ‘Albumin a Tanjung Zinc Content of Snakehead Fish (Channa striata) Extract and its Role in Health’, International Journal of Science and Technology, 1, 1- 8.




DOI: https://doi.org/10.22146/mot.45080

Article Metrics

Abstract views : 3185 | views : 2994

Refbacks

  • There are currently no refbacks.


Bookmark and Share


Copyright (c) 2019 Majalah Obat Tradisional

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

©Majalah Obat Tradisional (Traditional Medicine Journal)
 ISSN 2406-9086
Faculty of Pharmacy
Universitas Gadjah Mada