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Submitted
Jan 2, 2025
Accepted
Mar 26, 2025
Published
May 19, 2025
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Chemical Compound Analysis of Syzygium myrtifolium Essential Oil and Molecular Docking Analysis on Phenylalanine Hydroxylase Enzyme
Corresponding Author(s) : Zikri Hamidi
zikrihamidi62@gmail.com
Jurnal Ilmu Kehutanan,
Vol 19 No 1 (2025): March
Abstract
Essential oil from the red shoot plant(Syzygium myrtifolium) had high potential as a non-timber forest product. Therefore, this research aimed to evaluate the effect of leaves storage duration on oil yield, essential oil quality, and compliance with the Indonesian National Standard (SNI) 06-237-2006 for clove leaf oil. This research performed steam distillation to produce essential oil from fresh leaves, leaves stored for 24 hours, and leaves stored for 48 hours. The results showed that the highest essential oil yield was obtained from the 24-hour stored leaves at 0.204%, in line with the SNI 06-237-2006. The Gas Chromatography-Mass Spectrometry (GC-MS) analysis showed that the main compounds in the product were beta-pinene (39.09%) and caryophyllene (23.74%). Based on the in silico results from molecular docking, there was a strong interaction between the essential oil compounds and the enzyme phenylalanine hydroxylase. In addition, humulene, ledene, and caryophyllene exhibited the highest binding affinities due to the molecular stability of the enzyme at residues Phe A:254 and Tyr A:325. The current research opened opportunities for developing essential oil-based products for health applications.
Keywords
Syzygium myrtifolium
Gas Chromatography-Mass Spectrometry
molecular docking
phenylalanine hydroxylase
Hamidi, Z. (2025). Chemical Compound Analysis of Syzygium myrtifolium Essential Oil and Molecular Docking Analysis on Phenylalanine Hydroxylase Enzyme. Jurnal Ilmu Kehutanan, 19(1), 92-101. https://doi.org/10.22146/jik.v19i1.19038
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