Myrmecodia platytyrea Methanol Tuber Extract Ameliorates Hyperglycemia In STZ-Induced Diabetic Sprague-Dawley Male Rats

  • Mizaton Hazizul Hasan Faculty of Pharmacy, Universiti Teknologi MARA, Selangor Campus, 42300 Bandar Puncak Alam, Selangor, Malaysia.
  • Hasbullani Zakaria Faculty of Pharmacy, Universiti Teknologi MARA, Selangor Campus, 42300 Bandar Puncak Alam, Selangor, Malaysia.
  • Ibtisam Abdul Wahab Faculty of Pharmacy, Universiti Teknologi MARA, Selangor Campus, 42300 Bandar Puncak Alam, Selangor, Malaysia
  • Thellie Ponto School of Pharmacy and Biomedical Sciences, Curtin University, Perth, WA 6845, Australia.
  • Aishah Adam Faculty of Pharmacy, Universiti Teknologi MARA, Selangor Campus, 42300 Bandar Puncak Alam, Selangor, Malaysia.
Keywords: streptozotocin, antihyperglycaemic, Myrmecodia platytyrea, T2DM, STZ-induced

Abstract

Type 2 diabetes mellitus (T2DM) is one of the main non-communicable chronic diseases that has many complications that compromise the quality of life. Hence, the need to find alternatives to replace the current therapy or as an adjuvant. Tubers of Myrmecodia platytytrea (Rubiaceae) has been used traditionally as an alternative therapy for the management of cancer and other inflammatory-related disorders. The aim of this study was to investigate the potency of M. platytytrea methanolic tuber extract (MPMTE) as an antihyperglycemic agent, in vivo. :The streptozotocin (STZ)-induced diabetic rats were treated orally with MPMTE (100, 200 and 400 mg/kg) and metformin (positive control, 100 mg/kg) daily for 14 days. Blood glucose level and other biochemistry analysis were conducted including histological examination on liver, kidney and pancreas.  The STZ-induced diabetic rats treated with MPMTE (200 and 400 mg/kg) had significant decreased (p<0.05) in fasting blood glucose, total cholesterol, triglycerides and low-density lipoprotein (LDL) with no significant changes in high-density lipoprotein (HDL) compared to STZ-induced untreated diabetic rats. Liver, kidney and pancreas were devoid of any damage caused by STZ.  MPMTE had strong antihyperglycaemic activity and was protective against any STZ-induced organ damage. Thus, MPMTE can be further developed into an adjuvant therapy for diabetic patients.

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Published
2021-09-29
How to Cite
Hazizul Hasan, M., Zakaria, H., Abdul Wahab, I., Ponto, T., & Adam, A. (2021). Myrmecodia platytyrea Methanol Tuber Extract Ameliorates Hyperglycemia In STZ-Induced Diabetic Sprague-Dawley Male Rats. Indonesian Journal of Pharmacy, 32(3), 338-348. https://doi.org/10.22146/ijp.880
Section
Research Article